|
|
 Previous Article | Table of Contents | Next Article 
Clinical Significance of HLA-DRB1*0410 in Japanese Patients With
Idiopathic Thrombocytopenic Purpura
Shosaku Nomura,
Tatsunori Matsuzaki,
Yoshio Ozaki,
Manabu Yamaoka,
Chie Yoshimura,
Kaoruko Katsura,
Gui Lan Xie,
Hideo Kagawa,
Tomoko Ishida, and
Shirou Fukuhara
From the First Department of Internal Medicine and the Department of
Blood Transfusion, Kansai Medical University, Osaka, Japan.
We performed HLA-A, -B, and -C antigen and -DR DNA typing in 111 Japanese patients with idiopathic thrombocytopenic purpura (ITP).
DRB1*0410 was significantly increased in ITP patients compared with
healthy controls (relative risk = 9.52, P < .05), but
the other DRB1*04 alleles showed no significant differences. On HLA-DR serotyping, patients with Vogt-Koyanagi-Harada disease (VKH) had a high
frequency of DR4, so we compared the frequencies of DRB1*04 suballeles
between ITP and VKH. The high frequency of DRB1*04 was dependent on
DRB1*0405 in VKH, but on DRB1*0410 in ITP. Plasma autoantibodies were
studied in 111 patients using a microtiter well assay. Thirty-six
patients had anti-GPIIb/IIIa autoantibodies, and antibody positivity
was associated with HLA-DR4 (29 of 36, 80.6% v 28 of 75, 37.3%) but not with DRB1*0410. When HLA-DR4 and DRB1*0410 were
compared between patients with a good or poor response to prednisolone,
HLA-DR4 was decreased and DRB1*0410 was significantly decreased
( 2 = 11.455, P < .01) in patients with a
good response. In conclusion, this study showed that genetically
determined factors influence the course of ITP. However, our findings
should be considered preliminary because of possible racial differences
in HLA status between Japanese and other ITP patients.
Blood, Vol. 91 No. 10 (May 15), 1998:
pp. 3616-3622
© 1998 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Nomura, K. Ishii, N. Inami, T. Matsuzaki, M. Yamaoka, F. Urase, Y. Maeda, and S. Fukuhara
Antiglycoprotein IIb-IIIa Autoantibody in a Patient With Immune Thrombocytopenia After Cord Blood Transplantation
Clinical and Applied Thrombosis/Hemostasis,
February 1, 2009;
15(1):
123 - 124.
[PDF]
|
|
|
|
|
|
|
D. Veneri, M. Gottardi, E. Guizzardi, C. Zanuso, M. Krampera, M. Franchini, G. Emilia, M. Luppi, M. Morselli, G. Longo, et al.
Idiopathic thrombocytopenic purpura, Helicobacter pylori infection, and HLA class II alleles
Blood,
August 13, 2002;
100(5):
1925 - 1927.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Yeo, S.-N. Park, Y.-S. Park, B.-D. Suh, H. Han, H.-B. Choi, and T.-G. Kim
Different Distribution of HLA Class II Alleles According to Response to Corticosteroid Therapy in Sudden Sensorineural Hearing Loss
Arch Otolaryngol Head Neck Surg,
August 1, 2001;
127(8):
945 - 949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Miura, C. J. Thoburn, E. C. Bright, M. Sommer, S. Lefell, M. Ueda, S. Nakao, and A. D. Hess
Characterization of the T-cell repertoire in autologous graft-versus-host disease (GVHD): evidence for the involvement of antigen-driven T-cell response in the development of autologous GVHD
Blood,
August 1, 2001;
98(3):
868 - 876.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
