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Antibodies to Protease-Activated Receptor 3 Inhibit Activation of
Mouse Platelets by Thrombin
Hiroaki Ishihara,
Dewan Zeng,
Andrew J. Connolly,
Carmen Tam, and
Shaun R. Coughlin
From the Cardiovascular Research Institute, Daiichi Research Center,
and the Departments of Medicine and Pharmacology, University of
California, San Francisco, San Francisco, CA.
Recent studies of mice deficient in the thrombin receptor,
protease-activated receptor 1 (PAR1), provided definitive evidence for
the existence of a second thrombin receptor in mouse platelets. We
recently identified a new thrombin receptor designated
protease-activated receptor 3 (PAR3). The mRNA encoding a mouse
homologue of PAR3 was highly expressed in mouse splenic megakaryocytes,
making it a good candidate for the missing mouse platelet thrombin
receptor. We now report that PAR3 protein is expressed on the surface
of mouse platelets and that PAR3 antibodies partially inhibit
activation of mouse platelets by thrombin but not U46619, a thromboxane
receptor agonist. These observations suggest that PAR3 contributes to
mouse platelet activation by thrombin.
Blood, Vol. 91 No. 11 (June 1), 1998:
pp. 4152-4157
© 1998 by The American Society of Hematology.
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