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Characteristic Pattern of Chromosomal Gains and Losses in Primary
Large B-Cell Lymphomas of the Gastrointestinal Tract
Thomas F.E. Barth,
Hartmut Döhner,
Claudius A. Werner,
Stephan Stilgenbauer,
Magdalena Schlotter,
Michael Pawlita,
Peter Lichter,
Peter Möller, and
Martin Bentz
From Medizinische Klinik und Poliklinik V, Universität
Heidelberg, Heidelberg; Pathologisches Institut der Universität
Ulm, Ulm; and Deutsches Krebsforschungszentrum, Heidelberg, Germany.
In contrast to low-grade B-cell lymphomas originating in the
gastrointestinal (GI) tract, only few cytogenetic data are available for the large cell, highly malignant variants. We studied 31 large B-cell lymphomas of the GI tract by comparative genomic hybridization (CGH) and fluorescence in situ hybridization using specific DNA probes
(FISH). The most frequent aberrations were gains of all or of parts of
chromosomes 11 (11 cases), 12 (9 cases), 1q (4 cases), and 3q (4 cases). Losses of parts of chromosome 6q and of parts of the short arm
of chromosome 17 (6 cases each) were found most frequently. In four
cases a total of seven high-level DNA amplifications was detected. In
two of these cases, involvement of specific protooncogenes (REL
and MYC) was shown. Some genetic aberrations seemed to be
associated with an inferior clinical course: patients with
 2 aberrations had a significantly shorter median
survival. Furthermore, all patients with gains of all or parts of
chromosome arm 1q and with high-level DNA amplifications as well as
seven of nine patients with gains of all or parts of chromosome 12 died
of lymphoma. In conclusion, the pattern of chromosomal gains and losses
in large B-cell lymphomas was different from data reported for
low-grade (MALT) lymphomas of the stomach and bowel, especially with
respect to the high incidence of partial gains of chromosome arm 11q
and of all or parts of chromosome 12 and the low frequency of polysomy
3. In addition, our data suggest that chromosomal gains and losses
detected by CGH and FISH may predict for the outcome of patients with
this tumor entity.
Blood, Vol. 91 No. 11 (June 1), 1998:
pp. 4321-4330
© 1998 by The American Society of Hematology.
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