|
|
Previous Article | Table of Contents | Next Article 
Frequent Dysregulation of the c-maf Proto-Oncogene at 16q23 by
Translocation to an Ig Locus in Multiple Myeloma
Marta Chesi,
P. Leif Bergsagel,
Oluwatoyin O. Shonukan,
Maria
Luisa Martelli,
Leslie A. Brents,
Theresa Chen,
Evelin Schröck,
Thomas Ried, and
W. Michael Kuehl
From the Genetics Department, Medicine Branch, National Cancer
Institute, Bethesda, MD; the Department of Medicine, Division of
Hematology and Oncology, Cornell University Medical College, New York,
NY; and the Genome Technology Branch, National Institutes of
Health-National Center for Human Genome Research, Bethesda, MD.
Dysregulation of oncogenes by translocation to an IgH (14q32) or IgL
( , 2p11 or , 22q11) locus is a frequent event in the pathogenesis
of B-cell tumors. Translocations involving an IgH locus and a diverse
but nonrandom array of chromosomal loci occur in most multiple myeloma
(MM) tumors even though the translocations often are not detected by
conventional cytogenetic analysis. In a continuing analysis of
translocations in 21 MM lines, we show that the novel, karyotypically
silent t(14;16)(q32.3;q23) translocation is present in 5 MM lines, with
cloned breakpoints from 4 lines dispersed over an approximately 500-kb
region centromeric to the c-maf proto-oncogene at 16q23.
Another line has a t(16;22)(q23;q11), with the breakpoint telomeric to
c-maf, so that the translocation breakpoints in these 6 lines
bracket c-maf. Only these 6 lines overexpress c-maf
mRNA. As predicted for dysregulation of c-maf by translocation,
there is selective expression of one c-maf allele in 2 informative lines with translocations. This is the first human tumor in
which the basic zipper c-maf transcription factor is shown to function
as an oncogene.
Blood, Vol. 91 No. 12 (June 15), 1998:
pp. 4457-4463
© 1998 by The American Society of Hematology.

CiteULike Connotea Del.icio.us Digg Reddit Technorati What's this?
This article has been cited by other articles:

|
 |

|
 |
 
J Yeung and H Chang
Genomic aberrations and immunohistochemical markers as prognostic indicators in multiple myeloma
J. Clin. Pathol.,
July 1, 2008;
61(7):
832 - 836.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Lauring, A. M. Abukhdeir, H. Konishi, J. P. Garay, J. P. Gustin, Q. Wang, R. J. Arceci, W. Matsui, and B. H. Park
The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity
Blood,
January 15, 2008;
111(2):
856 - 864.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. W. Jenner, P. E. Leone, B. A. Walker, F. M. Ross, D. C. Johnson, D. Gonzalez, L. Chiecchio, E. Dachs Cabanas, G. Paolo Dagrada, M. Nightingale, et al.
Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma
Blood,
November 1, 2007;
110(9):
3291 - 3300.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Gonzalez, M. van der Burg, R. Garcia-Sanz, J. A. Fenton, A. W. Langerak, M. Gonzalez, J. J. M. van Dongen, J. F. San Miguel, and G. J. Morgan
Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma
Blood,
November 1, 2007;
110(9):
3112 - 3121.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Atayar, A. van den Berg, T. Blokzijl, M. Boot, R. D Gascoyne, L. Visser, and S. Poppema
Hodgkin's lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments
J. Clin. Pathol.,
October 1, 2007;
60(10):
1092 - 1097.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. W.-L. Wong, J. W. Clendening, A. Martirosyan, P. C. Boutros, C. Bros, F. Khosravi, I. Jurisica, A. K. Stewart, P. L. Bergsagel, and L. Z. Penn
Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma
Mol. Cancer Ther.,
June 1, 2007;
6(6):
1886 - 1897.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Avet-Loiseau, M. Attal, P. Moreau, C. Charbonnel, F. Garban, C. Hulin, S. Leyvraz, M. Michallet, I. Yakoub-Agha, L. Garderet, et al.
Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myelome
Blood,
April 15, 2007;
109(8):
3489 - 3495.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Fonseca and A. K. Stewart
Targeted therapeutics for multiple myeloma: The arrival of a risk-stratified approach
Mol. Cancer Ther.,
March 1, 2007;
6(3):
802 - 810.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. R. Cook, M. Hartke, J. Pettay, and R. R. Tubbs
Fluorescence in Situ Hybridization Analysis of Immunoglobulin Heavy Chain Translocations in Plasma Cell Myeloma Using Intact Paraffin Sections and Simultaneous CD138 Immunofluorescence
J. Mol. Diagn.,
September 1, 2006;
8(4):
459 - 465.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. Massrieh, A. Derjuga, F. Doualla-Bell, C.-Y. Ku, B. M. Sanborn, and V. Blank
Regulation of the MAFF Transcription Factor by Proinflammatory Cytokines in Myometrial Cells
Biol Reprod,
April 1, 2006;
74(4):
699 - 705.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Bisping, M. Kropff, D. Wenning, B. Dreyer, S. Bessonov, F. Hilberg, G. J. Roth, G. Munzert, M. Stefanic, M. Stelljes, et al.
Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups
Blood,
March 1, 2006;
107(5):
2079 - 2089.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Morito, K. Yoh, Y. Fujioka, T. Nakano, H. Shimohata, Y. Hashimoto, A. Yamada, A. Maeda, F. Matsuno, H. Hata, et al.
Overexpression of c-Maf Contributes to T-Cell Lymphoma in Both Mice and Human
Cancer Res.,
January 15, 2006;
66(2):
812 - 819.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. Agnelli, S. Bicciato, M. Mattioli, S. Fabris, D. Intini, D. Verdelli, L. Baldini, F. Morabito, V. Callea, L. Lombardi, et al.
Molecular Classification of Multiple Myeloma: A Distinct Transcriptional Profile Characterizes Patients Expressing CCND1 and Negative for 14q32 Translocations
J. Clin. Oncol.,
October 10, 2005;
23(29):
7296 - 7306.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. Jaksic, S. Trudel, H. Chang, Y. Trieu, X. Qi, J. Mikhael, D. Reece, C. Chen, and A. K. Stewart
Clinical Outcomes in t(4;14) Multiple Myeloma: A Chemotherapy-Sensitive Disease Characterized by Rapid Relapse and Alkylating Agent Resistance
J. Clin. Oncol.,
October 1, 2005;
23(28):
7069 - 7073.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. L. Bergsagel and W. M. Kuehl
Molecular Pathogenesis and a Consequent Classification of Multiple Myeloma
J. Clin. Oncol.,
September 10, 2005;
23(26):
6333 - 6338.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. K. Stewart and R. Fonseca
Prognostic and Therapeutic Significance of Myeloma Genetics and Gene Expression Profiling
J. Clin. Oncol.,
September 10, 2005;
23(26):
6339 - 6344.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Chen, I. R. Williams, B. H. Lee, N. Duclos, B. J. P. Huntly, D. J. Donoghue, and D. G. Gilliland
Constitutively activated FGFR3 mutants signal through PLC{gamma}-dependent and -independent pathways for hematopoietic transformation
Blood,
July 1, 2005;
106(1):
328 - 337.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Finnis, S. Dayan, L. Hobson, G. Chenevix-Trench, K. Friend, K. Ried, D. Venter, E. Woollatt, E. Baker, and R. I. Richards
Common chromosomal fragile site FRA16D mutation in cancer cells
Hum. Mol. Genet.,
May 15, 2005;
14(10):
1341 - 1349.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Turcotte, S. Gauthier, A. Tuite, A. Mullick, D. Malo, and P. Gros
A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice
J. Exp. Med.,
March 21, 2005;
201(6):
881 - 890.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Cao, J. Liu, L. Song, and X. Ma
The Protooncogene c-Maf Is an Essential Transcription Factor for IL-10 Gene Expression in Macrophages
J. Immunol.,
March 15, 2005;
174(6):
3484 - 3492.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. Chenais, A. Derjuga, W. Massrieh, K. Red-Horse, V. Bellingard, S. J. Fisher, and V. Blank
Functional and Placental Expression Analysis of the Human NRF3 Transcription Factor
Mol. Endocrinol.,
January 1, 2005;
19(1):
125 - 137.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. Atayar, S. Poppema, T. Blokzijl, G. Harms, M. Boot, and A. van den Berg
Expression of the T-Cell Transcription Factors, GATA-3 and T-bet, in the Neoplastic Cells of Hodgkin Lymphomas
Am. J. Pathol.,
January 1, 2005;
166(1):
127 - 134.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. Magrangeas, M.-L. Cormier, G. Descamps, N. Gouy, L. Lode, M.-P. Mellerin, J.-L. Harousseau, R. Bataille, S. Minvielle, and H. Avet-Loiseau
Light-chain only multiple myeloma is due to the absence of functional (productive) rearrangement of the IgH gene at the DNA level
Blood,
May 15, 2004;
103(10):
3869 - 3875.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Stromberg, A. Dimberg, A. Hammarberg, K. Carlson, A. Osterborg, K. Nilsson, and H. Jernberg-Wiklund
Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone
Blood,
April 15, 2004;
103(8):
3138 - 3147.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Fonseca, B. Barlogie, R. Bataille, C. Bastard, P. L. Bergsagel, M. Chesi, F. E. Davies, J. Drach, P. R. Greipp, I. R. Kirsch, et al.
Genetics and Cytogenetics of Multiple Myeloma: A Workshop Report
Cancer Res.,
February 15, 2004;
64(4):
1546 - 1558.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Cuendet, K. Christov, D. D. Lantvit, Y. Deng, S. Hedayat, L. Helson, J. D. McChesney, and J. M. Pezzuto
Multiple Myeloma Regression Mediated by Bruceantin
Clin. Cancer Res.,
February 1, 2004;
10(3):
1170 - 1179.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Valanciute, S. le Gouvello, B. Solhonne, A. Pawlak, P. Grimbert, L. Lyonnet, S. Hue, P. Lang, P. Remy, R. Salomon, et al.
NF-{kappa}B p65 Antagonizes IL-4 Induction by c-maf in Minimal Change Nephrotic Syndrome
J. Immunol.,
January 1, 2004;
172(1):
688 - 698.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Brocke-Heidrich, A. K. Kretzschmar, G. Pfeifer, C. Henze, D. Loffler, D. Koczan, H.-J. Thiesen, R. Burger, M. Gramatzki, and F. Horn
Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation
Blood,
January 1, 2004;
103(1):
242 - 251.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Soverini, M. Cavo, C. Cellini, C. Terragna, E. Zamagni, D. Ruggeri, N. Testoni, P. Tosi, A. de Vivo, M. Amabile, et al.
Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation
Blood,
September 1, 2003;
102(5):
1588 - 1594.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Fonseca, E. Blood, M. Rue, D. Harrington, M. M. Oken, R. A. Kyle, G. W. Dewald, B. Van Ness, S. A. Van Wier, K. J. Henderson, et al.
Clinical and biologic implications of recurrent genomic aberrations in myeloma
Blood,
June 1, 2003;
101(11):
4569 - 4575.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R V Jamieson, F Munier, A Balmer, N Farrar, R Perveen, and G C M Black
Pulverulent cataract with variably associated microcornea and iris coloboma in a MAF mutation family
Br. J. Ophthalmol.,
April 1, 2003;
87(4):
411 - 412.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. J. Keats, T. Reiman, C. A. Maxwell, B. J. Taylor, L. M. Larratt, M. J. Mant, A. R. Belch, and L. M. Pilarski
In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression
Blood,
February 15, 2003;
101(4):
1520 - 1529.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Cao, J. Liu, M. Chesi, P. L. Bergsagel, I-C. Ho, R. P. Donnelly, and X. Ma
Differential Regulation of IL-12 and IL-10 Gene Expression in Macrophages by the Basic Leucine Zipper Transcription Factor c-Maf Fibrosarcoma
J. Immunol.,
November 15, 2002;
169(10):
5715 - 5725.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. S. Nelson, N. Clegg, H. Arnold, C. Ferguson, M. Bonham, J. White, L. Hood, and B. Lin
The program of androgen-responsive genes in neoplastic prostate epithelium
PNAS,
September 3, 2002;
99(18):
11890 - 11895.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. J. Cousins, T. H. Lee, and D. Z. Staynov
Cytokine Coexpression During Human Th1/Th2 Cell Differentiation: Direct Evidence for Coordinated Expression of Th2 Cytokines
J. Immunol.,
September 1, 2002;
169(5):
2498 - 2506.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. O. Claudio, E. Masih-Khan, H. Tang, J. Goncalves, M. Voralia, Z. H. Li, V. Nadeem, E. Cukerman, O. Francisco-Pabalan, C. C. Liew, et al.
A molecular compendium of genes expressed in multiple myeloma
Blood,
August 28, 2002;
100(6):
2175 - 2186.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Fonseca, R. J. Bailey, G. J. Ahmann, S. V. Rajkumar, J. D. Hoyer, J. A. Lust, R. A. Kyle, M. A. Gertz, P. R. Greipp, and G. W. Dewald
Genomic abnormalities in monoclonal gammopathy of undetermined significance
Blood,
July 30, 2002;
100(4):
1417 - 1424.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. Fonseca, E. A. Blood, M. M. Oken, R. A. Kyle, G. W. Dewald, R. J. Bailey, S. A. Van Wier, K. J. Henderson, J. D. Hoyer, D. Harrington, et al.
Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients
Blood,
May 15, 2002;
99(10):
3735 - 3741.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Avet-Loiseau, T. Facon, B. Grosbois, F. Magrangeas, M.-J. Rapp, J.-L. Harousseau, S. Minvielle, and R. Bataille
Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation
Blood,
March 15, 2002;
99(6):
2185 - 2191.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. V. Jamieson, R. Perveen, B. Kerr, M. Carette, J. Yardley, E. Heon, M. G. Wirth, V. van Heyningen, D. Donnai, F. Munier, et al.
Domain disruption and mutation of the bZIP transcription factor, MAF,associated with cataract, ocular anterior segment dysgenesis and coloboma
Hum. Mol. Genet.,
January 1, 2002;
11(1):
33 - 42.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Avet-Loiseau, F. Gerson, F. Magrangeas, S. Minvielle, J.-L. Harousseau, and R. Bataille
Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors
Blood,
November 15, 2001;
98(10):
3082 - 3086.
[Abstract]
[Full Text]
[PDF]
|
 |
|
|