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Hydrogen Peroxide Is Involved in Collagen-Induced Platelet Activation
Pasquale Pignatelli,
Fabio M. Pulcinelli,
Luisa Lenti,
Pier Paolo
Gazzaniga, and
Francesco Violi
From the Department of Experimental Medicine and Pathology and
Institute of 1st Clinical Medicine, University La Sapienza, Rome,
Italy.
In this study, we investigated whether (1) collagen-induced platelet
aggregation is associated with a burst of H2O2,
(2) this oxidant species is involved in the activation of platelets,
and (3) the pathways of platelet activation are stimulated by
H2O2. Collagen-induced platelet aggregation was
associated with production of H2O2, which was
abolished by catalase, an enzyme that destroys H2O2. H2O2 production
was not observed when ADP or thrombin were used as agonists. Catalase
inhibited dose-dependently thromboxane A2 production,
release of arachidonic acid from platelet membrane, and Inositol
1,4,5P3 (IP3) formation. In aspirin-treated platelets stimulated with high concentrations of collagen, catalase inhibited platelet aggregation, calcium mobilization, and IP3 production. This
study suggests that collagen-induced platelet aggregation is associated
with a burst of H2O2 that acts as a second
messenger by stimulating the arachidonic acid metabolism and
phospholipase C pathway.
Blood, Vol. 91 No. 2 (January 15), 1998:
pp. 484-490
© 1998 by The American Society of Hematology.
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