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The Metastatic Characteristics of Murine Lymphoma Cell Lines In
Vivo Are Manifested After Target Organ Invasion
Fawzi Aoudjit,
Edouard F. Potworowski, and
Yves St-Pierre
From the Immunology Research Center, Institut Armand-Frappier,
Université du Québec, Québec, Canada.
The ability of a tumor cell to survive is critical for successful
dissemination to sites distant from the primary tumor. Tumor cells must
enter blood circulation, resist hemodynamic shear stress of the blood
circulation, successfully extravasate, and then migrate through dense
tissue stroma to a site favorable for tumor growth. Some tumor cells
must therefore be endowed with peculiar abilities to successfully
metastasize, whereas others, although capable of forming tumor in
specific organs, cannot metastasize. This property has often been
associated with the homing ability of a given tumor cell, likely
through the expression of organ-specific homing receptors that are
critical for the extravasation process. The present work was aimed at
establishing the point at which metastatic and nonmetastatic lymphoma
cells diverge. Although 164T2 and 267T2 lymphoma cell lines can
successfully form thymic lymphoma when injected intrathymically, only
the 164T2 clone can efficiently form tumor in kidneys, spleen, and
liver after intravenous inoculation. Using the Indium-labeling
technique to monitor the homing kinetic of both cell lines, we showed
that the critical step for the successful metastasis of the lymphoma
cell was determined in the final steps of the disseminating process,
namely after homing. These results indicate that, whereas binding of
tumor cells to vascular endothelium through specific adhesion
mechanisms is a prerequisite for dissemination of tumor cells, the
resistance of a tumor cell to the antagonist action of the host
and/or its ability to grow tumor occurs only after homing to
the target organ.
Blood, Vol. 91 No. 2 (January 15), 1998:
pp. 623-629
© 1998 by The American Society of Hematology.
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