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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ericson, S. G. Articles by Landreth, K. S. Search for Related Content PubMed PubMed Citation Articles by Ericson, S. G. Articles by Landreth, K. S. Related Collections Phagocytes Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Interleukin-6 Production by Human Neutrophils After Fc-Receptor Cross-Linking or Exposure to Granulocyte Colony-Stimulating Factor Solveig G. Ericson, Yue Zhao, Huilan Gao, Kathryn L. Miller, Laura F. Gibson, Joseph P. Lynch, and Kenneth S. Landreth From the Departments of Medicine, Microbiology/Immunology, and Pediatrics and the Blood and Marrow Transplantation Program of the Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV. Polymorphonuclear neutrophils (PMNs) are essential effector cells in host defense and tissue inflammatory responses. These responses may be initiated after cross-linking of cell surface Fc receptors that bind the constant portion of IgG (FcR). We evaluated the effect of cross-linking FcRI or FcRII on interleukin-6 (IL-6) production by purified PMNs from normal donors or from patients being treated with recombinant human granulocyte colony-stimulating factor (rhG-CSF). In PMNs from normal donors, IL-6 mRNA was detected by reverse transcriptase-polymerase chain reaction only after FcRI or FcRII cross-linking. We also found that IL-6 mRNA could be detected in PMNs after either in vitro or in vivo rhG-CSF treatment in the absence of FcR cross-linking. IL-6 protein was found to be produced intracellularly and secreted by PMNs after cross-linking FcRI or FcRII or after rhG-CSF stimulation. Cross-linking FcRI or FcRII on PMNs from patients treated with rhG-CSF resulted in a synergistic increase in IL-6 secretion. Upregulation of IL-6 production by PMNs after rhG-CSF treatment may contribute to a clinical engraftment syndrome that occurs during periods of rapid increase in PMN numbers in patients receiving rhG-CSF. Blood, Vol. 91 No. 6 (March 15), 1998: pp. 2099-2107 © 1998 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Y. McClintock and E. M. Wagner Role of IL-6 in systemic angiogenesis of the lung J Appl Physiol, September 1, 2005; 99(3): 861 - 866. [Abstract] [Full Text] [PDF] F. Al-Mohanna, S. Saleh, R. S. Parhar, K. Khabar, and K. 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