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Adenovirus-Mediated Human Immunodeficiency Virus-1 Nef Expression
in Human Monocytes/Macrophages and Effect of Nef on Downmodulation
of Fc Receptors and Expression of Monokines
Swapan K. De,
Chettemgere N.S. Venkateshan,
Prem Seth,
D. Carleton
Gajdusek, and
Clarence J. Gibbs Jr
From the Oral Infection and Immunity Branch, National Institute of
Dental Research, the Laboratory of Central Nervous System Studies,
National Institute of Neurological Disorders and Stroke, and the
Division of Cancer Treatment, Medicine Branch, National Cancer
Institute, National Institutes of Health, Bethesda, MD.
To characterize the effect of human immunodeficiency virus-1 (HIV-1)
nef expression in human monocytes/macrophage (HMØ) and U937 on
the levels of Fc Rs, HLA antigens, and monokines, elutriated HMØs
and U937 cells were transfected with an adenovirus-mediated Nef
expression system. Nef-expressing cells downmodulated FcRI, FcRII, and upregulated HLA class I molecules. Nef-expressing HMØs,
treated with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA), overexpressed tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and IL-10. However, IL-6 was induced by LPS
and inhibited by PMA. Additionally, a subpopulation of Nef-expressing HMØs underwent apoptosis. Our data suggest that HIV-1 nef
downmodulated FcRs in myeloid cells in a manner similar to that
previously reported for its effect on CD4+ in T cells.
Blood, Vol. 91 No. 6 (March 15), 1998:
pp. 2108-2117
© 1998 by The American Society of Hematology.
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