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Human T-Cell Leukemia Virus Type II Directly Acts on
CD34+ Hematopoietic Precursors by Increasing Their
Survival Potential. Envelope-Associated HLA Class II Molecules Reverse
This Effect
Claudio Casoli,
Maria Carla Re,
Paola Monari,
Giuliano Furlini,
Giovanna Tosi,
Chiara Gradozzi,
Pier Paolo Dall'Aglio, Umberto Bertazzoni, and
Roberto S. Accolla
From the Institute of Medical Pathology, University of Parma, Parma;
the Department of Clinical and Experimental Medicine, the Division of
Microbiology, University of Bologna, Bologna; the Institute of Biology
and Genetics, University of Verona, Verona; the Chair of General
Pathology, Medical School II, University of Pavia at Varese; and
Advanced Biotechnology Center, Genova, Italy.
The role of human T-cell leukemia virus type II (HTLV-II) in human
lymphoproliferative and hematopoietic abnormalities in which the
retrovirus can be isolated is still elusive. Here we show that the C344
T-cell-derived lymphotropic HTLV-II type IIa Mo strain acts directly
on CD34+ hematopoietic precursors by rescuing them from
apoptosis induced by interleukin-3 (IL-3) deprivation. This effect is
viral strain-specific, as it is not observed with the B-lymphotropic
HTLV-II type IIb Gu strain, it does not require infection of the
hematopoietic precursors, and, interestingly, it is strongly dependent
on the infected cellular host from which the virus was
derived. Indeed, growth adaptation of the Mo strain to the permissive
B-cell line, BJAB, renders the virus no longer capable of mediating the
antiapoptotic effect. However, pretreatment of the BJAB-adapted Mo
strain with antibodies specific for HLA class II, but not class I,
histocompatibility antigens restores the antiapoptotic potential of the
virus. These results constitute the first evidence that HTLV-II
retrovirus can directly influence the homeostasis of human progenitors,
without infecting them, and that this crucial activity is strongly
inhibited by the presence of host-derived envelope-associated HLA class II antigens.
Blood, Vol. 91 No. 7 (April 1), 1998:
pp. 2296-2304
© 1998 by The American Society of Hematology.
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