|
|
 Previous Article | Table of Contents | Next Article 
SPECIAL FOCUS
Reduced Retinoic Acid-Sensitivities of Nuclear Receptor Corepressor
Binding to PML- and PLZF-RAR Underlie Molecular Pathogenesis and
Treatment of Acute Promyelocytic Leukemia
Fabien Guidez,
Sarah Ivins,
Jun Zhu,
Mats Söderström,
Samuel Waxman, and
Arthur Zelent
From the Leukaemia Research Fund Centre at the Institute of Cancer
Research, Chester Beatty Laboratories, London, UK; the Department of
Cell Biology, Faculty of Health Sciences, University of
Linköping, Linköping, Sweden; and the Department of
Medicine, Mount Sinai School of Medicine, New York, NY.
Typical acute promyelocytic leukemia (APL) is associated with
expression of the PML-RAR fusion protein and responsiveness to
treatment with all-trans retinoic acid (ATRA). A rare, but recurrent, APL has been described that does not respond to ATRA treatment and is associated with a variant chromosomal translocation and expression of the PLZF-RAR fusion protein. Both PML- and PLZF-RAR possess identical RAR sequences and inhibit ATRA-induced gene transcription as well as cell differentiation. We now show that
the above-mentioned oncogenic fusion proteins interact with the nuclear
receptor corepressor N-CoR and, in comparison with the wild-type RAR
protein, their interactions display reduced sensitivities to ATRA.
Although pharmacologic concentration of ATRA could still induce
dissociation of N-CoR from PML-RAR, it had a very little effect on
its association with the PLZF-RAR fusion protein. This
ATRA-insensitive interaction between N-CoR and PLZF-RAR was mediated
by the N-terminal PLZF moiety of the chimera. It appears that
N-CoR/histone deacetylase corepressor complex interacts directly in an
ATRA-insensitive manner with the BTB/POZ-domain of the wild-type PLZF
protein and is required, at least in part, for its function as a
transcriptional repressor. As the above-noted results predict, histone
deacetylase inhibitors antagonize oncogenic activities of the
PML-RAR fusion protein and partially relieve transcriptional
repression by PLZF as well as inhibitory effect of PLZF-RAR on ATRA
response. Taken together, our results demonstrate involvement of
nuclear receptor corepressor/histone deacetylase complex in the
molecular pathogenesis of APL and provide an explanation for
differential sensitivities of PML- and PLZF-RAR-associated leukemias to ATRA.
Blood, Vol. 91 No. 8 (April 15), 1998:
pp. 2634-2642
© 1998 by The American Society of Hematology.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. F. Burande, M. L. Heuze, I. Lamsoul, B. Monsarrat, S. Uttenweiler-Joseph, and P. G. Lutz
A Label-free Quantitative Proteomics Strategy to Identify E3 Ubiquitin Ligase Substrates Targeted to Proteasome Degradation
Mol. Cell. Proteomics,
July 1, 2009;
8(7):
1719 - 1727.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Naray-Fejes-Toth, C. Boyd, and G. Fejes-Toth
Regulation of epithelial sodium transport by promyelocytic leukemia zinc finger protein
Am J Physiol Renal Physiol,
July 1, 2008;
295(1):
F18 - F26.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. P. Ng, J. Howe Fong, D. Sijin Nin, J. L. Hirpara, N. Asou, C.-S. Chen, S. Pervaiz, and M. Khan
Cleavage of misfolded nuclear receptor corepressor confers resistance to unfolded protein response-induced apoptosis.
Cancer Res.,
October 15, 2006;
66(20):
9903 - 9912.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Jing, N. Hellinger, L. Xia, A. Monks, E. A. Sausville, A. Zelent, and S. Waxman
Benzodithiophenes Induce Differentiation and Apoptosis in Human Leukemia Cells
Cancer Res.,
September 1, 2005;
65(17):
7847 - 7855.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Xu, F. Guidez, A. Glasow, D. Chung, K. Petrie, K. Stegmaier, K.-K. Wang, J. Zhang, Y. Jing, A. Zelent, et al.
Benzodithiophenes Potentiate Differentiation of Acute Promyelocytic Leukemia Cells by Lowering the Threshold for Ligand-Mediated Corepressor/Coactivator Exchange with Retinoic Acid Receptor {alpha} and Enhancing Changes in all-trans-Retinoic Acid-Regulated Gene Expression
Cancer Res.,
September 1, 2005;
65(17):
7856 - 7865.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Puccetti, X. Zheng, D. Brambilla, A. Seshire, T. Beissert, S. Boehrer, H. Nurnberger, D. Hoelzer, O. G. Ottmann, C. Nervi, et al.
The Integrity of the Charged Pocket in the BTB/POZ Domain Is Essential for the Phenotype Induced by the Leukemia-Associated t(11;17) Fusion Protein PLZF/RAR{alpha}
Cancer Res.,
July 15, 2005;
65(14):
6080 - 6088.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Guidez, L. Howell, M. Isalan, M. Cebrat, R. M. Alani, S. Ivins, I. Hormaeche, M. J. McConnell, S. Pierce, P. A. Cole, et al.
Histone Acetyltransferase Activity of p300 Is Required for Transcriptional Repression by the Promyelocytic Leukemia Zinc Finger Protein
Mol. Cell. Biol.,
July 1, 2005;
25(13):
5552 - 5566.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ishizuka and M. A. Lazar
The Nuclear Receptor Corepressor Deacetylase Activating Domain Is Essential for Repression by Thyroid Hormone Receptor
Mol. Endocrinol.,
June 1, 2005;
19(6):
1443 - 1451.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Kumar, A. E. Gururaj, R. K. Vadlamudi, and S. K. Rayala
The Clinical Relevance of Steroid Hormone Receptor Corepressors
Clin. Cancer Res.,
April 15, 2005;
11(8):
2822 - 2831.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Nanba, A. Mammoto, K. Hashimoto, and S. Higashiyama
Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF
J. Cell Biol.,
November 10, 2003;
163(3):
489 - 502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Farboud, H. Hauksdottir, Y. Wu, and M. L. Privalsky
Isotype-Restricted Corepressor Recruitment: a Constitutively Closed Helix 12 Conformation in Retinoic Acid Receptors {beta} and {gamma} Interferes with Corepressor Recruitment and Prevents Transcriptional Repression
Mol. Cell. Biol.,
April 15, 2003;
23(8):
2844 - 2858.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-L. Couderc, D. Godt, S. Zollman, J. Chen, M. Li, S. Tiong, S. E. Cramton, I. Sahut-Barnola, and F. A. Laski
The bric a brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila
Development,
March 7, 2003;
129(10):
2419 - 2433.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Ravandi, M. Talpaz, and Z. Estrov
Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies
Clin. Cancer Res.,
February 1, 2003;
9(2):
535 - 550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Jing, L. Xia, and S. Waxman
Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia
Blood,
July 18, 2002;
100(3):
1008 - 1013.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B.-W. Gu, H. Xiong, Y. Zhou, B. Chen, L. Wang, S. Dong, Z.-Y. Yu, L.-F. Lu, M. Zhong, H.-F. Yin, et al.
Variant-type PML-RARalpha fusion transcript in acute promyelocytic leukemia: Use of a cryptic coding sequence from intron 2 of the RARalpha gene and identification of a new clinical subtype resistant to retinoic acid therapy
PNAS,
May 15, 2002;
(2002)
112194799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tsuzuki and T. Enver
Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein
Blood,
May 1, 2002;
99(9):
3404 - 3410.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Alland, G. David, H. Shen-Li, J. Potes, R. Muhle, H.-C. Lee, H. Hou Jr., K. Chen, and R. A. DePinho
Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex
Mol. Cell. Biol.,
April 15, 2002;
22(8):
2743 - 2750.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. B. Maurer, C. Wichmann, A. Gross, H. Kunkel, T. Heinzel, M. Ruthardt, B. Groner, and M. Grez
The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex
Blood,
April 15, 2002;
99(8):
2647 - 2652.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Hummel, T. Zhang, R. A. Wells, and S. Kamel-Reid
The Retinoic Acid Receptor {alpha} (RAR{alpha}) Chimeric Proteins PML-, PLZF-, NPM-, and NuMA-RAR{alpha} Have Distinct Intracellular Localization Patterns
Cell Growth Differ.,
April 1, 2002;
13(4):
173 - 183.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Slack, S. Waxman, G. Tricot, M. S. Tallman, and C. D. Bloomfield
Advances in the Management of Acute Promyelocytic Leukemia and Other Hematologic Malignancies with Arsenic Trioxide
Oncologist,
April 1, 2002;
7(90001):
1 - 13.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Melnick, G. Carlile, K. F. Ahmad, C.-L. Kiang, C. Corcoran, V. Bardwell, G. G. Prive, and J. D. Licht
Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors
Mol. Cell. Biol.,
March 15, 2002;
22(6):
1804 - 1818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Zhu, J.-W. Zhang, H.-Q. Zhu, Y.-L. Shen, M. Flexor, P.-M. Jia, Y. Yu, X. Cai, S. Waxman, M. Lanotte, et al.
Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk
Blood,
February 1, 2002;
99(3):
1014 - 1022.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. C. Guibal, C. Moog-Lutz, P. Smolewski, Y. Di Gioia, Z. Darzynkiewicz, P. G. Lutz, and Y. E. Cayre
ASB-2 Inhibits Growth and Promotes Commitment in Myeloid Leukemia Cells
J. Biol. Chem.,
January 4, 2002;
277(1):
218 - 224.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. O. Ward, M. J. McConnell, G. W. Carlile, P. P. Pandolfi, J. D. Licht, and L. P. Freedman
The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D3-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D3 receptor
Blood,
December 1, 2001;
98(12):
3290 - 3300.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-H. Hong, Z. Yang, and M. L. Privalsky
Arsenic Trioxide Is a Potent Inhibitor of the Interaction of SMRT Corepressor with Its Transcription Factor Partners, Including the PML-Retinoic Acid Receptor {alpha} Oncoprotein Found in Human Acute Promyelocytic Leukemia
Mol. Cell. Biol.,
November 1, 2001;
21(21):
7172 - 7182.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Gore, L.-J. Weng, S. Zhai, W. D. Figg, R. C. Donehower, G. J. Dover, M. Grever, C. A. Griffin, L. B. Grochow, E. K. Rowinsky, et al.
Impact of the Putative Differentiating Agent Sodium Phenylbutyrate on Myelodysplastic Syndromes and Acute Myeloid Leukemia
Clin. Cancer Res.,
August 1, 2001;
7(8):
2330 - 2339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Kastner, H. J. Lawrence, C. Waltzinger, N. B. Ghyselinck, P. Chambon, and S. Chan
Positive and negative regulation of granulopoiesis by endogenous RAR{alpha}
Blood,
March 1, 2001;
97(5):
1314 - 1320.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Zhang, B. A. Hug, E. Y. Huang, C. W. Chen, V. Gelmetti, M. Maccarana, S. Minucci, P. G. Pelicci, and M. A. Lazar
Oligomerization of ETO Is Obligatory for Corepressor Interaction
Mol. Cell. Biol.,
January 1, 2001;
21(1):
156 - 163.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Melnick, G. W. Carlile, M. J. McConnell, A. Polinger, S. W. Hiebert, and J. D. Licht
AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein
Blood,
December 1, 2000;
96(12):
3939 - 3947.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Albagli, C. Lindon, D. Lantoine, S. Quief, E. Puvion, C. Pinset, and F. Puvion-Dutilleul
DNA Replication Progresses on the Periphery of Nuclear Aggregates Formed by the BCL6 Transcription Factor
Mol. Cell. Biol.,
November 15, 2000;
20(22):
8560 - 8570.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. J. BURKE and A. BANIAHMAD
Co-repressors 2000
FASEB J,
October 1, 2000;
14(13):
1876 - 1888.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F. Guidez, K. Petrie, A. M. Ford, H. Lu, C. A. Bennett, A. MacGregor, J. Hannemann, Y. Ito, J. Ghysdael, M. Greaves, et al.
Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein
Blood,
October 1, 2000;
96(7):
2557 - 2561.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Melnick, K. F. Ahmad, S. Arai, A. Polinger, H. Ball, K. L. Borden, G. W. Carlile, G. G. Prive, and J. D. Licht
In-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions
Mol. Cell. Biol.,
September 1, 2000;
20(17):
6550 - 6567.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E. M. Rego, L.-Z. He, R. P. Warrell Jr., Z.-G. Wang, and P. P. Pandolfi
Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins
PNAS,
August 17, 2000;
(2000)
180290497.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T.-X. Liu, J.-W. Zhang, J. Tao, R.-B. Zhang, Q.-H. Zhang, C.-J. Zhao, J.-H. Tong, M. Lanotte, S. Waxman, S.-J. Chen, et al.
Gene expression networks underlying retinoic acid-induced differentiation of acute promyelocytic leukemia cells
Blood,
August 15, 2000;
96(4):
1496 - 1504.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Grignani, M. Valtieri, M. Gabbianelli, V. Gelmetti, R. Botta, L. Luchetti, B. Masella, O. Morsilli, E. Pelosi, P. Samoggia, et al.
PML/RARalpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype
Blood,
August 15, 2000;
96(4):
1531 - 1537.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. L. Redner, J. D. Chen, E. A. Rush, H. Li, and S. L. Pollock
The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties
Blood,
April 15, 2000;
95(8):
2683 - 2690.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Rusiniak, M. Yu, D. T. Ross, E. C. Tolhurst, and J. L. Slack
Identification of B94 (TNFAIP2) as a Potential Retinoic Acid Target Gene in Acute Promyelocytic Leukemia
Cancer Res.,
April 1, 2000;
60(7):
1824 - 1829.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. M. Melnick, J. J. Westendorf, A. Polinger, G. W. Carlile, S. Arai, H. J. Ball, B. Lutterbach, S. W. Hiebert, and J. D. Licht
The ETO Protein Disrupted in t(8;21)-Associated Acute Myeloid Leukemia Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein
Mol. Cell. Biol.,
March 15, 2000;
20(6):
2075 - 2086.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Huang and S. J. Brandt
mSin3A Regulates Murine Erythroleukemia Cell Differentiation through Association with the TAL1 (or SCL) Transcription Factor
Mol. Cell. Biol.,
March 15, 2000;
20(6):
2248 - 2259.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. Li, C. Leo, J. Zhu, X. Wu, J. O'Neil, E.-J. Park, and J. D. Chen
Sequestration and Inhibition of Daxx-Mediated Transcriptional Repression by PML
Mol. Cell. Biol.,
March 1, 2000;
20(5):
1784 - 1796.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. C. Kogan, S.-h. Hong, D. B. Shultz, M. L. Privalsky, and J. M. Bishop
Leukemia initiated by PMLRARalpha : the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable
Blood,
March 1, 2000;
95(5):
1541 - 1550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Zhu, M. Gianni, E. Kopf, N. Honore, M. Chelbi-Alix, M. Koken, F. Quignon, C. Rochette-Egly, and H. de The
Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha ) and oncogenic RARalpha fusion proteins
PNAS,
December 21, 1999;
96(26):
14807 - 14812.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Williams, S. C. Blacklow, and T. Collins
The Zinc Finger-Associated SCAN Box Is a Conserved Oligomerization Domain
Mol. Cell. Biol.,
December 1, 1999;
19(12):
8526 - 8535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Hoatlin, Y. Zhi, H. Ball, K. Silvey, A. Melnick, S. Stone, S. Arai, N. Hawe, G. Owen, A. Zelent, et al.
A Novel BTB/POZ Transcriptional Repressor Protein Interacts With the Fanconi Anemia Group C Protein and PLZF
Blood,
December 1, 1999;
94(11):
3737 - 3747.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Zhang, H. Xiong, L.-X. Kan, C.-K. Zhang, X.-F. Jiao, G. Fu, Q.-H. Zhang, L. Lu, J.-H. Tong, B.-W. Gu, et al.
Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene
PNAS,
September 28, 1999;
96(20):
11422 - 11427.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kukita, T. Kukita, M. Ouchida, H. Maeda, H. Yatsuki, and O. Kohashi
Osteoclast-Derived Zinc Finger (OCZF) Protein With POZ Domain, a Possible Transcriptional Repressor, Is Involved in Osteoclastogenesis
Blood,
September 15, 1999;
94(6):
1987 - 1997.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Arnould, C. Philippe, V. Bourdon, M. J. Gregoire, R. Berger, and P. Jonveaux
The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor {alpha} in acute promyelocytic-like leukaemia
Hum. Mol. Genet.,
September 1, 1999;
8(9):
1741 - 1749.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Doetzlhofer, H. Rotheneder, G. Lagger, M. Koranda, V. Kurtev, G. Brosch, E. Wintersberger, and C. Seiser
Histone Deacetylase 1 Can Repress Transcription by Binding to Sp1
Mol. Cell. Biol.,
August 1, 1999;
19(8):
5504 - 5511.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Grand, S. Kulkarni, A. Chase, J. M. Goldman, M. Gordon, and N. C. P. Cross
Frequent Deletion of hSNF5/INI1, a Component of the SWI/SNF Complex, in Chronic Myeloid Leukemia
Cancer Res.,
August 1, 1999;
59(16):
3870 - 3874.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. L. Redner, J. Wang, and J. M. Liu
Chromatin Remodeling and Leukemia: New Therapeutic Paradigms
Blood,
July 15, 1999;
94(2):
417 - 428.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Du, R. L. Redner, M. P. Cooke, and C. Lavau
Overexpression of Wild-Type Retinoic Acid Receptor alpha (RARalpha ) Recapitulates Retinoic Acid-Sensitive Transformation of Primary Myeloid Progenitors by Acute Promyelocytic Leukemia RARalpha -Fusion Genes
Blood,
July 15, 1999;
94(2):
793 - 802.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G.-X. Cheng, X.-H. Zhu, X.-Q. Men, L. Wang, Q.-H. Huang, X. L. Jin, S.-M. Xiong, J. Zhu, W.-M. Guo, J.-Q. Chen, et al.
Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha
PNAS,
May 25, 1999;
96(11):
6318 - 6323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Melnick and J. D. Licht
Deconstructing a Disease: RAR{alpha}, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
Blood,
May 15, 1999;
93(10):
3167 - 3215.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Muto, M. Kizaki, K. Yamato, Y. Kawai, M. Kamata-Matsushita, H. Ueno, M. Ohguchi, T. Nishihara, H. P. Koeffler, and Y. Ikeda
1,25-Dihydroxyvitamin D3 Induces Differentiation of a Retinoic Acid-Resistant Acute Promyelocytic Leukemia Cell Line (UF-1) Associated With Expression of p21WAF1/CIP1 and p27KIP1
Blood,
April 1, 1999;
93(7):
2225 - 2233.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Gelmetti, J. Zhang, M. Fanelli, S. Minucci, P. G. Pelicci, and M. A. Lazar
Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO
Mol. Cell. Biol.,
December 1, 1998;
18(12):
7185 - 7191.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. F. Ahmad, C. K. Engel, and G. G. Prive
Crystal structure of the BTB domain from PLZF
PNAS,
October 13, 1998;
95(21):
12123 - 12128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Nervi, F. F. Ferrara, M. Fanelli, M. R. Rippo, B. Tomassini, P. F. Ferrucci, M. Ruthardt, V. Gelmetti, C. Gambacorti-Passerini, D. Diverio, et al.
Caspases Mediate Retinoic Acid-Induced Degradation of the Acute Promyelocytic Leukemia PML/RARalpha Fusion Protein
Blood,
October 1, 1998;
92(7):
2244 - 2251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Shaknovich, P. L. Yeyati, S. Ivins, A. Melnick, C. Lempert, S. Waxman, A. Zelent, and J. D. Licht
The Promyelocytic Leukemia Zinc Finger Protein Affects Myeloid Cell Growth, Differentiation, and Apoptosis
Mol. Cell. Biol.,
September 1, 1998;
18(9):
5533 - 5545.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. J. Collins
Acute Promyelocytic Leukemia: Relieving Repression Induces Remission
Blood,
April 15, 1998;
91(8):
2631 - 2633.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Rego, L.-Z. He, R. P. Warrell Jr., Z.-G. Wang, and P. P. Pandolfi
Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins
PNAS,
August 29, 2000;
97(18):
10173 - 10178.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
