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The SH2-Containing Inositol Polyphosphate 5-Phosphatase, Ship, Is
Expressed During Hematopoiesis and Spermatogenesis
Qiurong Liu,
Fouad Shalaby,
Jamie Jones,
Denis Bouchard, and
Daniel J. Dumont
From the Amgen Institute, Toronto, Ontario, Canada; Samuel Lunenfeld
Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; and
the Department of Medical Biophysics, University of Toronto, Toronto,
Ontario, Canada.
Ship is a recently identified SH2-containing inositol
polyphosphate 5-phosphatase that has been implicated as an important signaling molecule in cell-culture systems. To understand the physiologic function of Ship in vivo, we performed expression studies
of Ship during mouse development. Results of this study demonstrate the
expression of ship to be in late primitive-streak stage embryos
(7.5 days postcoitus [dpc]), when hematopoiesis is thought to begin,
and the expression is restricted to the hematopoietic lineage in mouse
embryo. In adult mice, Ship expression continues to be in the majority
of cells from hematopoietic origin, including granulocytes, monocytes,
and lymphocytes, and is also found in the spermatids of the testis.
Furthermore, the level of Ship expression is developmentally regulated
during T-cell maturation. These results suggest a possible role for
Ship in the differentiation and maintenance of the hematopoietic
lineages and in spermatogenesis.
Blood, Vol. 91 No. 8 (April 15), 1998:
pp. 2753-2759
© 1998 by The American Society of Hematology.
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