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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Okuda, T. Articles by Downing, J. R. Search for Related Content PubMed PubMed Citation Articles by Okuda, T. Articles by Downing, J. R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors Tsukasa Okuda, Zhongling Cai, Shouli Yang, Noel Lenny, Chuhl-joo Lyu, Jan M.A. van Deursen, Hironori Harada, and James R. Downing From the Departments of Pathology and Laboratory Medicine, Tumor Cell Biology, and Genetics, St Jude Children's Research Hospital, Memphis, TN. The t(8;21)-encoded AML1-ETO chimeric product is believed to be causally involved in up to 15% of acute myelogenous leukemias through an as yet unknown mechanism. To directly investigate the role of AML1-ETO in leukemogenesis, we used gene targeting to create an AML1-ETO "knock-in" allele that mimics the t(8;21). Unexpectedly, embryos heterozygous for AML1-ETO (AML1-ETO/+) died around E13.5 from a complete absence of normal fetal liver-derived definitive hematopoiesis and lethal hemorrhages. This phenotype was similar to that seen following homozygous disruption of either AML1 or CBF. However, in contrast to AML1- or CBF-deficient embryos, fetal livers from AML1-ETO/+ embryos contained dysplastic multilineage hematopoietic progenitors that had an abnormally high self-renewal capacity in vitro. To further document the role of AML1-ETO in these growth abnormalities, we used retroviral transduction to express AML1-ETO in murine adult bone marrow-derived hematopoietic progenitors. AML1-ETO-expressing cells were again found to have an increased self-renewal capacity and could be readily established into immortalized cell lines in vitro. Taken together, these studies suggest that AML1-ETO not only neutralizes the normal biologic activity of AML1 but also directly induces aberrant hematopoietic cell proliferation. Blood, Vol. 91 No. 9 (May 1), 1998: pp. 3134-3143 © 1998 by The American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Osman, V. Gobert, F. Ponthan, O. Heidenreich, M. Haenlin, and L. Waltzer A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO PNAS, July 21, 2009; 106(29): 12043 - 12048. 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Nordheim AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells Blood, April 15, 2003; 101(8): 3157 - 3163. [Abstract] [Full Text] [PDF] M. L. Kalev-Zylinska, J. A. Horsfield, M. V. C. Flores, J. H. Postlethwait, M. R. Vitas, A. M. Baas, P. S. Crosier, and K. E. Crosier Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis Development, March 6, 2003; 129(8): 2015 - 2030. [Abstract] [Full Text] [PDF] A. Tonks, L. Pearn, A. J. Tonks, L. Pearce, T. Hoy, S. Phillips, J. Fisher, J. R. Downing, A. K. Burnett, and R. L. Darley The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells Blood, January 15, 2003; 101(2): 624 - 632. [Abstract] [Full Text] [PDF] S. Wotton, M. Stewart, K. Blyth, F. Vaillant, A. Kilbey, J. C. Neil, and E. R. Cameron Proviral Insertion Indicates a Dominant Oncogenic Role for Runx1/AML-1 in T-Cell Lymphoma Cancer Res., December 15, 2002; 62(24): 7181 - 7185. [Abstract] [Full Text] [PDF] L. van der Weyden, D. J. Adams, and A. Bradley Tools for targeted manipulation of the mouse genome Physiol Genomics, December 3, 2002; 11(3): 133 - 164. [Abstract] [Full Text] [PDF] T. Kummalue, J. Lou, and A. D. Friedman Multimerization via Its Myosin Domain Facilitates Nuclear Localization and Inhibition of Core Binding Factor (CBF) Activities by the CBF{beta}-Smooth Muscle Myosin Heavy Chain Myeloid Leukemia Oncoprotein Mol. Cell. Biol., December 1, 2002; 22(23): 8278 - 8291. [Abstract] [Full Text] [PDF] K. Barseguian, B. Lutterbach, S. W. Hiebert, J. Nickerson, J. B. Lian, J. L. Stein, A. J. van Wijnen, and G. S. Stein Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins PNAS, November 26, 2002; 99(24): 15434 - 15439. [Abstract] [Full Text] [PDF] M. Schwieger, J. Lohler, J. Friel, M. Scheller, I. Horak, and C. Stocking AML1-ETO Inhibits Maturation of Multiple Lymphohematopoietic Lineages and Induces Myeloblast Transformation in Synergy with ICSBP Deficiency J. Exp. Med., November 4, 2002; 196(9): 1227 - 1240. [Abstract] [Full Text] [PDF] J. Basecke, L. Cepek, C. Mannhalter, J. Krauter, S. Hildenhagen, G. Brittinger, L. Trumper, and F. Griesinger Transcription of AML1/ETO in bone marrow and cord blood of individuals without acute myelogenous leukemia Blood, August 28, 2002; 100(6): 2267 - 2267. [Full Text] [PDF] D. G. Gilliland and J. D. Griffin The roles of FLT3 in hematopoiesis and leukemia Blood, August 13, 2002; 100(5): 1532 - 1542. [Abstract] [Full Text] [PDF] C. G. de Guzman, A. J. Warren, Z. Zhang, L. Gartland, P. Erickson, H. Drabkin, S. W. Hiebert, and C. A. Klug Hematopoietic Stem Cell Expansion and Distinct Myeloid Developmental Abnormalities in a Murine Model of the AML1-ETO Translocation Mol. Cell. Biol., August 1, 2002; 22(15): 5506 - 5517. [Abstract] [Full Text] [PDF] B. A. Hug, S. Y. D. Lee, E. L. Kinsler, J. Zhang, and M. A. Lazar Cooperative Function of Aml1-ETO Corepressor Recruitment Domains in the Expansion of Primary Bone Marrow Cells Cancer Res., May 1, 2002; 62(10): 2906 - 2912. [Abstract] [Full Text] [PDF] J. Pedersen-Bjergaard, M. K. Andersen, D. H. Christiansen, and C. Nerlov Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia Blood, March 15, 2002; 99(6): 1909 - 1912. [Abstract] [Full Text] [PDF] J. Michaud, F. Wu, M. Osato, G. M. Cottles, M. Yanagida, N. Asou, K. Shigesada, Y. Ito, K. F. Benson, W. H. Raskind, et al. In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis Blood, February 15, 2002; 99(4): 1364 - 1372. [Abstract] [Full Text] [PDF] J. C. Mulloy, J. Cammenga, K. L. MacKenzie, F. J. Berguido, M. A. S. Moore, and S. D. Nimer The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells Blood, January 1, 2002; 99(1): 15 - 23. [Abstract] [Full Text] [PDF] L. M. Kelly, Q. Liu, J. L. Kutok, I. R. Williams, C. L. Boulton, and D. G. Gilliland FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model Blood, January 1, 2002; 99(1): 310 - 318. [Abstract] [Full Text] [PDF] J. Dang, T. Inukai, H. Kurosawa, K. Goi, T. Inaba, N. T. Lenny, J. R. Downing, S. Stifani, and A. T. Look The E2A-HLF Oncoprotein Activates Groucho-Related Genes and Suppresses Runx1 Mol. Cell. Biol., September 1, 2001; 21(17): 5935 - 5945. [Abstract] [Full Text] [PDF] Y. Yuan, L. Zhou, T. Miyamoto, H. Iwasaki, N. Harakawa, C. J. Hetherington, S. A. Burel, E. Lagasse, I. L. Weissman, K. Akashi, et al. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations PNAS, August 28, 2001; 98(18): 10398 - 10403. [Abstract] [Full Text] [PDF] S. A. Burel, N. Harakawa, L. Zhou, T. Pabst, D. G. Tenen, and D.-E. Zhang Dichotomy of AML1-ETO Functions: Growth Arrest versus Block of Differentiation Mol. Cell. Biol., August 15, 2001; 21(16): 5577 - 5590. [Abstract] [Full Text] [PDF] L. J. Rush, Z. Dai, D. J. Smiraglia, X. Gao, F. A. Wright, M. Fruhwald, J. F. Costello, W. A. Held, L. Yu, R. Krahe, et al. Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci Blood, May 15, 2001; 97(10): 3226 - 3233. [Abstract] [Full Text] [PDF] J. D. Miller, T. Stacy, P. P. Liu, and N. A. Speck Core-binding factor {beta} (CBF{beta}), but not CBF{beta}-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBF{beta}-deficient embryonic stem cells Blood, April 15, 2001; 97(8): 2248 - 2256. [Abstract] [Full Text] [PDF] A. Melnick, G. W. Carlile, M. J. McConnell, A. Polinger, S. W. Hiebert, and J. D. Licht AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein Blood, December 1, 2000; 96(12): 3939 - 3947. [Abstract] [Full Text] [PDF] K. L. Rhoades, C. J. Hetherington, N. Harakawa, D. A. Yergeau, L. Zhou, L.-Q. Liu, M.-T. Little, D. G. Tenen, and D.-E. Zhang Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model Blood, September 15, 2000; 96(6): 2108 - 2115. [Abstract] [Full Text] [PDF] H. Shimada, H. Ichikawa, S. Nakamura, R. Katsu, M. Iwasa, I. Kitabayashi, and M. Ohki Analysis of genes under the downstream control of the t(8;21) fusion protein AML1-MTG8: overexpression of the TIS11b (ERF-1, cMG1) gene induces myeloid cell proliferation in response to G-CSF Blood, July 15, 2000; 96(2): 655 - 663. [Abstract] [Full Text] [PDF] T. Miyamoto, I. L. Weissman, and K. Akashi AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation PNAS, June 20, 2000; 97(13): 7521 - 7526. [Abstract] [Full Text] [PDF] T. Okuda, K. Takeda, Y. Fujita, M. Nishimura, S. Yagyu, M. Yoshida, S. Akira, J. R. Downing, and T. Abe Biological Characteristics of the Leukemia-Associated Transcriptional Factor AML1 Disclosed by Hematopoietic Rescue of AML1-Deficient Embryonic Stem Cells by Using a Knock-in Strategy Mol. Cell. Biol., January 1, 2000; 20(1): 319 - 328. [Abstract] [Full Text] E. Hellstrom-Lindberg, C. Willman, A. J. Barrett, and Y. Saunthararajah Achievements in Understanding and Treatment of Myelodysplastic Syndromes Hematology, January 1, 2000; 2000(1): 110 - 132. [Abstract] [Full Text] [PDF] S. McNeil, C. Zeng, K. S. Harrington, S. Hiebert, J. B. Lian, J. L. Stein, A. J. van Wijnen, and G. S. Stein The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha 2 transcription factor PNAS, December 21, 1999; 96(26): 14882 - 14887. [Abstract] [Full Text] [PDF] B. Lutterbach, Y. Hou, K. L. Durst, and S. W. Hiebert The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor PNAS, October 26, 1999; 96(22): 12822 - 12827. [Abstract] [Full Text] [PDF] H. Harada, Y. Harada, D. P. O'Brien, D. S. Rice, C. W. Naeve, and J. R. Downing HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells Mol. Cell. Biol., May 1, 1999; 19(5): 3808 - 3815. [Abstract] [Full Text] [PDF] L.-Q. Liu, R. Ilaria Jr., P. D. Kingsley, A. Iwama, R. A. van Etten, J. Palis, and D.-E. Zhang A Novel Ubiquitin-Specific Protease, UBP43, Cloned from Leukemia Fusion Protein AML1-ETO-Expressing Mice, Functions in Hematopoietic Cell Differentiation Mol. Cell. Biol., April 1, 1999; 19(4): 3029 - 3038. [Abstract] [Full Text] [PDF] B. Lutterbach, J. J. Westendorf, B. Linggi, A. Patten, M. Moniwa, J. R. Davie, K. D. Huynh, V. J. Bardwell, R. M. Lavinsky, M. G. Rosenfeld, et al. ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors Mol. Cell. Biol., December 1, 1998; 18(12): 7176 - 7184. [Abstract] [Full Text] V. Gelmetti, J. Zhang, M. Fanelli, S. Minucci, P. G. Pelicci, and M. A. Lazar Aberrant Recruitment of the Nuclear Receptor Corepressor-Histone Deacetylase Complex by the Acute Myeloid Leukemia Fusion Partner ETO Mol. Cell. Biol., December 1, 1998; 18(12): 7185 - 7191. [Abstract] [Full Text] N. Adya, T. Stacy, N. A. Speck, and P. P. Liu The Leukemic Protein Core Binding Factor beta  (CBFbeta )-Smooth-Muscle Myosin Heavy Chain Sequesters CBFalpha 2 into Cytoskeletal Filaments and Aggregates Mol. Cell. Biol., December 1, 1998; 18(12): 7432 - 7443. [Abstract] [Full Text] M. Britos-Bray, M. Ramirez, W. Cao, X. Wang, P. P. Liu, C. I. Civin, and A. D. Friedman CBFbeta -SMMHC, Expressed in M4eo Acute Myeloid Leukemia, Reduces p53 Induction and Slows Apoptosis in Hematopoietic Cells Exposed to DNA-Damaging Agents Blood, December 1, 1998; 92(11): 4344 - 4352. [Abstract] [Full Text] [PDF] S. C. Kogan, E. Lagasse, S. Atwater, S.-c. Bae, I. Weissman, Y. Ito, and J. M. Bishop The PEBP2beta MYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia PNAS, September 29, 1998; 95(20): 11863 - 11868. [Abstract] [Full Text] [PDF]

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