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gp130, The Cytokine Common Signal-Transducer of Interleukin-6
Cytokine Family, Is Downregulated in T Cells In Vivo by Interleukin-6
Xue-Jie Wang,
Tetsuya Taga,
Kanji Yoshida,
Mikiyoshi Saito,
Tadamitsu Kishimoto, and
Hitoshi Kikutani
From the Department of Molecular Immunology, Research Institute for
Microbial Diseases, Osaka University, Osaka, Japan; the Department of
Molecular Cell Biology, Medical Research Institute, Tokyo Medical and
Dental University, Tokyo, Japan; Fuji Gotemba Research Laboratories,
Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan; and the Department of
Medicine III, Osaka University Medical School, Osaka, Japan.
gp130 is a common signal-transducing receptor component for the
interleukin-6 (IL-6) family of cytokines. To investigate the expression
of gp130 in T-cell subsets and its regulation, anti-murine gp130
monoclonal antibody (MoAb) was used for flow cytometric analysis. In
normal mice, gp130 was differentially expressed in thymocyte and
splenic T-cell subpopulations defined by CD4/CD8 expression. In aged
MRL/lpr mice, although gp130 expression was detectable in
splenic CD4+ or CD8+ T cells, gp130
expression was significantly downregulated. Because serum levels of
IL-6 and soluble IL-6 receptor (sIL-6R) are elevated in these mice, we
examined the possibility that the downregulation of gp130 expression on
splenic T cells might be produced in response to continuous activation
of gp130 by high levels of serum IL-6. In transgenic mice
overexpressing IL-6, gp130 expression in the splenic T cells was
significantly decreased. After stimulation with IL-6 in vitro, the
level of gp130 on CD4+ or CD8+ splenic T
cells from normal mice was significantly decreased. These results
suggest that the expression of gp130 in splenic T cells could be
downregulated by the IL-6 stimulation under physiological or
pathological circumstances.
Blood, Vol. 91 No. 9 (May 1), 1998:
pp. 3308-3314
© 1998 by The American Society of Hematology.
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