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6q Deletions in Acute Lymphoblastic Leukemia and Non-Hodgkin's
Lymphomas
Mats Merup,
Teresa Calero Moreno,
Mats Heyman,
Kristina Rönnberg,
Dan Grandér,
Rut Detlofsson,
Omid Rasool,
Yie Liu,
Stefan Söderhäll,
Gunnar Juliusson,
Gösta Gahrton, and
Stefan Einhorn
From Radiumhemmet and the Childhood Cancer Research Unit, Department
of Pediatrics, Karolinska Hospital, Stockholm; the Department of
Medicine, Karolinska Institute at Huddinge University Hospital,
Huddinge; and the Department of Hematology, University Hospital
Linköping, Linköping, Sweden.
Deletions on the long arm of chromosome 6 are frequently found in
acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphomas (NHL).
We have used polymerase chain reaction analysis to study loss of
heterozygosity of 16 microsatellite markers on chromosome 6 in 74 ALL
and 54 NHL patients. Our results show that deletions of 6q in ALL are
more frequent than what has been reported in previous studies,
occurring in at least 32% of the patients. The corresponding figure
for NHL patients is 7%. Our results define a region of minimal
deletion in ALL of less than 500 kb between markers D6S1709 and D6S434.
The common region of deletion in NHL is located telomeric of this
region. Thus, two different tumor suppressor genes on chromosome 6q
seem to be relevant for the development of lymphoid malignancies.
Blood, Vol. 91 No. 9 (May 1), 1998:
pp. 3397-3400
© 1998 by The American Society of Hematology.
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