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Reduced Ex Vivo Interleukin-8 Production by Neutrophils in Septic
and Nonseptic Systemic Inflammatory Response Syndrome
Christelle Marie,
Jane Muret,
Catherine Fitting,
Marie-Reine Losser,
Didier Payen, and
Jean-Marc Cavaillon
From Unité d'Immuno-Allergie, Institut Pasteur, Paris; and the
Department of Anaesthesia and Intensive Care Medicine, Hôpital
Lariboisière, Paris, France.
Ex vivo cytokine production by circulating lymphocytes and monocytes
is reduced in patients with infectious or noninfectious systemic
inflammatory response syndrome. Very few studies have addressed the
reactivity of polymorphonuclear cells (PMN). To analyze further the
relative contribution of systemic inflammatory response syndrome alone
or in combination with infection we studied the interleukin-8 (IL-8)
production by PMN isolated from patients who had undergone cardiac
surgery with cardiopulmonary bypass (CPB) and patients with sepsis.
Cells were activated with either lipopolysaccharide (LPS) or
heat-killed streptococci. Compared with healthy controls, the release
of IL-8 by PMN in both groups of patients was significantly reduced
whether activated by LPS, independently of its concentration and
origin, or by heat-killed streptococci. These observations suggest that
stressful conditions related to inflammation, independently of
infection, rapidly dampened the reactivity of circulating PMN. We
investigated whether the observed diminished reactivity of PMN might
reflect an endotoxin tolerance phenomenon. Our in vitro experiments
with PMN from healthy controls indicated that PMN could not be rendered
tolerant stricto sensu. However, our data suggested that LPS-induced
mediators such as IL-10 may be responsible for the observed anergy in
patients.
Blood, Vol. 91 No. 9 (May 1), 1998:
pp. 3439-3446
© 1998 by The American Society of Hematology.
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