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Localization of Receptors for Vasoactive Intestinal Peptide,
Somatostatin, and Substance P in Distinct Compartments of Human
Lymphoid Organs
Jean Claude Reubi,
Ursula Horisberger,
Andreas Kappeler, and
Jean
A. Laissue
From the Division of Cell Biology and Experimental Cancer Research,
Institute of Pathology, University of Berne, Berne, Switzerland.
Regulatory peptides, such as vasoactive intestinal peptide (VIP),
somatostatin (SS), or substance P (SP), are considered to play a role
in immune regulation. To localize the targets of these peptides in the
human immune system, their receptors have been evaluated with in vitro
receptor autoradiography in lymph nodes, tonsils, appendix, Peyer's
patches, spleen, and thymus. The three peptide receptors were detected
in all lymphoid tissues tested, but, unexpectedly, usually in distinct
compartments. In lymph nodes, palatine tonsils, vermiform appendix, and
Peyer's patches, VIP receptors were found in the CD3 positive zone
around lymphoid follicles; SS receptors in the germinal centers of
secondary follicles; and SP receptors mainly in interfollicular blood
vessels. In the spleen, VIP receptors were detected in periarterial
lymphatic sheaths, SS receptors in the red pulp, and SP receptors in
the central arteries. In the thymus, VIP receptors were present in cortex and medulla, SS receptors in the medulla, and SP receptors in
blood vessels. For comparison, cholecystokinin (CCK)-A and -B receptors
were not demonstrated in any of these tissues. These results suggest a
strong compartmentalization of the three peptide receptors in human
lymphoid tissues and represent the molecular basis for the
understanding of a very complex and interactive mode of action of these
peptides.
Blood, Vol. 92 No. 1 (July 1), 1998:
pp. 191-197
© 1998 by The American Society of Hematology.
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