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Complement Fragment-Induced Release of Neutrophils From Bone
Marrow and Sequestration Within Pulmonary Capillaries in Rabbits
Hiroshi Kubo,
Lori Graham,
Nicholas A. Doyle,
William M. Quinlan,
James C. Hogg, and
Claire M. Doerschuk
From the Physiology Program, the Department of Environmental Health,
Harvard School of Public Health, Boston, MA; the Herman B Wells Center
for Pediatric Research and the Section of Pulmonology and Intensive
Care, the Department of Pediatrics, Indiana University, Indianapolis,
IN; and the Pulmonary Research Laboratory, University of British
Columbia, Vancouver, BC, Canada.
Infusion of complement fragments induces rapid sequestration of
neutrophils within the pulmonary capillaries. This study examined the
contributions of the bone marrow (BM) and the liver to the accumulation
of neutrophils within the lungs. Complement fragments induced the
release of neutrophils from the BM within 7 minutes of infusion, and
these neutrophils sequestered in the lungs immediately upon reaching
the pulmonary capillaries. Neutrophils expressing high levels of
L-selectin were preferentially retained within the pulmonary
microvasculature. By 30 minutes after the infusion was stopped, the
circulating neutrophil counts had increased, primarily because of
release from the BM. The number of neutrophils sequestered in the lung
had decreased by only 27%, and the number of neutrophils in the liver
increased by 223%. These studies indicate that complement fragments
induce the release of neutrophils from the BM far more rapidly than
previously described. These newly released neutrophils immediately
sequester within the lung, increasing the number of neutrophils
available to injure the lung many fold beyond the number that were
circulating before infusion. The preferential retention of
L-selectin-expressing neutrophils likely reflects the requirement for
L-selectin-mediated adhesion in maintaining sequestered neutrophils
within the pulmonary microvasculature. The number of circulating
neutrophils reflects a balance between pulmonary sequestration, rapid
release from the BM, and uptake by the liver and other organs.
Blood, Vol. 92 No. 1 (July 1), 1998:
pp. 283-290
© 1998 by The American Society of Hematology.
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