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Perturbed Granulopoiesis in Mice With a Targeted Mutation in
the Granulocyte Colony-Stimulating Factor Receptor Gene Associated
With Severe Chronic Neutropenia
Mirjam H.A. Hermans,
Alister C. Ward,
Claudia Antonissen,
Alar Karis,
Bob Löwenberg, and
Ivo P. Touw
From the Institute of Hematology, Daniel den Hoed Cancer Center and
Erasmus University Rotterdam; and the Department of Cell Biology and
Genetics, Erasmus University Rotterdam, Rotterdam, The Netherlands.
Mutations in the granulocyte colony-stimulating factor
(G-CSF) receptor gene are found in a number of
patients with severe chronic neutropenia predisposed to acute myeloid
leukemia. These mutations result in the absence of the C-terminal
domain of the G-CSF-R, a region which has been implicated in
differentiation signaling. We generated mice with an equivalent
mutation (gcsfr- 715) by homologous and Cre-mediated
recombination in embryonic stem cells. Both wt/715 and
715/715 mice have significantly reduced numbers of blood
neutrophils compared with their wt/wt littermates. However,
under continuous G-CSF administration mutant mice develop peripheral
neutrophil counts that significantly exceed those of wild-type
littermates. These findings indicate that depending on G-CSF levels in
mice, the 715 mutation can contribute both to neutropenia
and to neutrophilia.
Blood, Vol. 92 No. 1 (July 1), 1998:
pp. 32-39
© 1998 by The American Society of Hematology.
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[Full Text]
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|
|
|
|
|
|
|
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1051 - 1062.
[Full Text]
[PDF]
|
|
|
|
|
|
|
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August 16, 1999;
190(4):
497 - 508.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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February 15, 1999;
189(4):
683 - 692.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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January 15, 1999;
93(2):
440 - 446.
[Abstract]
[Full Text]
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|
|
|
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January 15, 1999;
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447 - 458.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
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[Abstract]
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