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The Redox State as a Correlate of Senescence and Wasting and as a
Target for Therapeutic Intervention
Volker Hack,
Raoul Breitkreutz,
Ralf Kinscherf,
Helmut Röhrer,
Peter Bärtsch,
Friedemann Taut,
Axel Benner, and
Wulf Dröge
From the Division of Immunochemistry, Deutsches
Krebsforschungszentrum, Heidelberg; Onkologische Schwerpunktpraxis,
Ihringen; the Department of Sports Medicine, University of Heidelberg,
Heidelberg; the Department of Anesthesiology, University of Heidelberg,
Heidelberg; and the Biostatistics Unit, Deutsches
Kresbsforschungszentrum, Heidelberg, Germany.
The loss of body cell mass (bcm) in senescence and wasting is poorly
understood. We now show that the plasma cystine/acid soluble thiol
ratio, ie, an indicator of the redox state, is increased in old age and
cancer patients and correlated with a decrease in bcm and plasma
albumin. A cause/effect relationship was suggested by two independent
studies with N-acetyl-cysteine (NAC). NAC caused an increase in the bcm
of healthy persons with high plasma cystine/thiol ratios, and treatment
of cancer patients with NAC plus interleukin-2 caused an increase in
bcm, plasma albumin, and functional capacity. Albumin levels below 680 µmol/L were associated with an increase in body water. Our studies
suggest that the shift in the redox state may contribute to the loss of
bcm and may provide a quantitative guideline for therapeutic
intervention. Treatment of cancer patients with thiol-containing
antioxidants may improve the quality of life.
Blood, Vol. 92 No. 1 (July 1), 1998:
pp. 59-67
© 1998 by The American Society of Hematology.
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