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Blood, Vol. 92 No. 10 (November 15), 1998:
pp. 3780-3792
Efficient and Rapid Induction of a Chronic Myelogenous
Leukemia-Like Myeloproliferative Disease in Mice Receiving P210
bcr/abl-Transduced Bone Marrow
Warren S. Pear,
Juli P. Miller,
Lanwei Xu,
John C. Pui,
Benny Soffer,
Robert C. Quackenbush,
Ann Marie Pendergast,
Roderick Bronson,
Jon C. Aster,
Martin L. Scott, and
David Baltimore
From the Department of Pathology and Institute for Medicine and
Engineering, University of Pennsylvania, Philadelphia, PA; the
Department of Internal Medicine (Hematology/Oncology), Pharmacology,
and Cancer Biology, Duke University School of Medicine, Durham, NC; the
Department of Veterinary Medicine, Tufts University, Boston, MA; the
Department of Pathology, Brigham and Women's Hospital, Boston, MA; and
the Department of Biology, Massachusetts Institute of Technology,
Cambridge, MA.
Expression of the 210-kD bcr/abl fusion oncoprotein can cause a
chronic myelogenous leukemia (CML)-like disease in mice receiving bone
marrow cells transduced by bcr/abl-encoding retroviruses. However,
previous methods failed to yield this disease at a frequency sufficient
enough to allow for its use in the study of CML pathogenesis. To
overcome this limitation, we have developed an efficient and reproducible method for inducing a CML-like disease in mice receiving P210 bcr/abl-transduced bone marrow cells. All mice receiving P210
bcr/abl-transduced bone marrow cells succumb to a myeloproliferative disease between 3 and 5 weeks after bone marrow transplantation. The
myeloproliferative disease recapitulates many of the hallmarks of human
CML and is characterized by high white blood cell counts and extensive
extramedullary hematopoiesis in the spleen, liver, bone marrow, and
lungs. Use of a retroviral vector coexpressing P210 bcr/abl and green
fluorescent protein shows that the vast majority of bcr/abl-expressing
cells are myeloid. Analysis of the proviral integration pattern shows
that, in some mice, the myeloproliferative disease is clonal. In
multiple mice, the CML-like disease has been transplantable, inducing a
similar myeloproliferative syndrome within 1 month of transfer to
sublethally irradiated syngeneic recipients. The disease in many of
these mice has progressed to the development of acute lymphoma/leukemia
resembling blast crisis. These results demonstrate that murine CML
recapitulates important features of human CML. As such, it should be an
excellent model for addressing specific issues relating to the
pathogenesis and treatment of this disease.
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|
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|
|
|
|
|
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113(12):
2746 - 2754.
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[Full Text]
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|
|
|
|
|
|
|
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Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia
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March 12, 2009;
113(11):
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kato, J. Ding, E. Pisck, U. S. Jhala, and K. Du
COP1 Functions as a FoxO1 Ubiquitin E3 Ligase to Regulate FoxO1-mediated Gene Expression
J. Biol. Chem.,
December 19, 2008;
283(51):
35464 - 35473.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Antoku, K. Saksela, G. M. Rivera, and B. J. Mayer
A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors
J. Cell Sci.,
September 15, 2008;
121(18):
3071 - 3082.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Ko, N. Patel, T. Ikawa, H. Kawamoto, O. Frank, R. R. Rivera, R. A. Van Etten, and C. Murre
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September 2, 2008;
105(35):
12967 - 12972.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Kim, T. Miwa, Y. Kimura, R. A. Schwendener, M. van Lookeren Campagne, and W.-C. Song
Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
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August 15, 2008;
112(4):
1109 - 1119.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Li, H. Yao, Z. Zhang, M. Li, Y. Luo, P. R. Thompson, D. S. Gilmour, and Y. Wang
Regulation of p53 Target Gene Expression by Peptidylarginine Deiminase 4
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August 1, 2008;
28(15):
4745 - 4758.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF-{kappa}B Activation and Up-Regulation of c-FLIP and Bcl-xL
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181(2):
1001 - 1011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Mulky, T. V. Cohen, S. V. Kozlov, B. Korbei, R. Foisner, C. L. Stewart, and V. N. KewalRamani
The LEM Domain Proteins Emerin and LAP2{alpha} Are Dispensable for Human Immunodeficiency Virus Type 1 and Murine Leukemia Virus Infections
J. Virol.,
June 15, 2008;
82(12):
5860 - 5868.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Kavalerchik, D. Goff, and C. H.M. Jamieson
Chronic Myeloid Leukemia Stem Cells
J. Clin. Oncol.,
June 10, 2008;
26(17):
2911 - 2915.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tabone-Eglinger, F. Subra, H. El Sayadi, L. Alberti, E. Tabone, J.-P. Michot, N. Theou-Anton, A. Lemoine, J.-Y. Blay, and J.-F. Emile
KIT Mutations Induce Intracellular Retention and Activation of an Immature Form of the KIT Protein in Gastrointestinal Stromal Tumors
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14(8):
2285 - 2294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Podsypanina, K. Politi, L. J. Beverly, and H. E. Varmus
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras
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April 1, 2008;
105(13):
5242 - 5247.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Matte-Martone, J. Liu, D. Jain, J. McNiff, and W. D. Shlomchik
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April 1, 2008;
111(7):
3884 - 3892.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
H. Zheng, C. Matte-Martone, H. Li, B. E. Anderson, S. Venketesan, H. Sheng Tan, D. Jain, J. McNiff, and W. D. Shlomchik
Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease
Blood,
February 15, 2008;
111(4):
2476 - 2484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Furmanski, C. Ferreira, I. Bartok, S. Dimakou, J. Rice, F. K. Stevenson, M. M. Millrain, E. Simpson, and J. Dyson
Public T Cell Receptor -Chains Are Not Advantaged during Positive Selection
J. Immunol.,
January 15, 2008;
180(2):
1029 - 1039.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. John, J. L. Clements, L. M. Russell, and L. A. Garrett-Sinha
Ets-1 Regulates Plasma Cell Differentiation by Interfering with the Activity of the Transcription Factor Blimp-1
J. Biol. Chem.,
January 11, 2008;
283(2):
951 - 962.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Ren, Z. Chen, L. Chen, N. T. Woods, G. W. Reuther, J. Q. Cheng, H.-g. Wang, and J. Wu
Shp2E76K Mutant Confers Cytokine-independent Survival of TF-1 Myeloid Cells by Up-regulating Bcl-XL
J. Biol. Chem.,
December 14, 2007;
282(50):
36463 - 36473.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Metcalf, S. Glaser, S. Mifsud, L. Di Rago, and L. Robb
The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells
PNAS,
December 11, 2007;
104(50):
20013 - 20018.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Michie, A. C. Chan, M. Ciofani, M. Carleton, J. M. Lefebvre, Y. He, D. M. Allman, D. L. Wiest, J. C. Zuniga-Pflucker, and D. J. Izon
Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals
Int. Immunol.,
December 1, 2007;
19(12):
1421 - 1430.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Dileepan, S. C. Kachlany, N. V. Balashova, J. Patel, and S. K. Maheswaran
Human CD18 Is the Functional Receptor for Aggregatibacter actinomycetemcomitans Leukotoxin
Infect. Immun.,
October 1, 2007;
75(10):
4851 - 4856.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. O'Carroll, I. Mecklenbrauker, P. P. Das, A. Santana, U. Koenig, A. J. Enright, E. A. Miska, and A. Tarakhovsky
A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway
Genes & Dev.,
August 15, 2007;
21(16):
1999 - 2004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Caslini, Z. Yang, M. El-Osta, T. A. Milne, R. K. Slany, and J. L. Hess
Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation
Cancer Res.,
August 1, 2007;
67(15):
7275 - 7283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Chu, L. Li, H. Singh, and R. Bhatia
BCR-Tyrosine 177 Plays an Essential Role in Ras and Akt Activation and in Human Hematopoietic Progenitor Transformation in Chronic Myelogenous Leukemia
Cancer Res.,
July 15, 2007;
67(14):
7045 - 7053.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Peng, J. Brain, Y. Hu, A. Goodrich, L. Kong, D. Grayzel, R. Pak, M. Read, and S. Li
Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells
Blood,
July 15, 2007;
110(2):
678 - 685.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Hosen, T. Yamane, M. Muijtjens, K. Pham, M. F. Clarke, and I. L. Weissman
Bmi-1-Green Fluorescent Protein-Knock-In Mice Reveal the Dynamic Regulation of Bmi-1 Expression in Normal and Leukemic Hematopoietic Cells
Stem Cells,
July 1, 2007;
25(7):
1635 - 1644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yan, J.-K. Luo, K. J. Ritchie, I. Sakai, K. Takeuchi, R. Ren, and D.-E. Zhang
Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling
Blood,
July 1, 2007;
110(1):
305 - 312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Grande-Garcia, A. Echarri, J. de Rooij, N. B. Alderson, C. M. Waterman-Storer, J. M. Valdivielso, and M. A. del Pozo
Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases
J. Cell Biol.,
May 21, 2007;
177(4):
683 - 694.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. P. DeKoter, B. L. Schweitzer, M. B. Kamath, D. Jones, H. Tagoh, C. Bonifer, D. A. Hildeman, and K. J. Huang
Regulation of the Interleukin-7 Receptor {alpha} Promoter by the Ets Transcription Factors PU.1 and GA-binding Protein in Developing B Cells
J. Biol. Chem.,
May 11, 2007;
282(19):
14194 - 14204.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Courreges, D. Burzyn, I. Nepomnaschy, I. Piazzon, and S. R. Ross
Critical Role of Dendritic Cells in Mouse Mammary Tumor Virus In Vivo Infection
J. Virol.,
April 15, 2007;
81(8):
3769 - 3777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Zou, H. Chen, A. A. Schmaier, R. O. Hynes, and M. L. Kahn
Structure-function analysis reveals discrete {beta}3 integrin inside-out and outside-in signaling pathways in platelets
Blood,
April 15, 2007;
109(8):
3284 - 3290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Roberts, J. P. H. Lauritsen, M. Cooney, R. E. Parrott, E. O. Sajaroff, C. M. Win, M. D. Keller, J. H. Carpenter, J. Carabana, M. S. Krangel, et al.
T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3{zeta} subunit of the T-cell antigen receptor complex
Blood,
April 15, 2007;
109(8):
3198 - 3206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. O. Yang, A. D. Panopoulos, R. Nurieva, S. H. Chang, D. Wang, S. S. Watowich, and C. Dong
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
J. Biol. Chem.,
March 30, 2007;
282(13):
9358 - 9363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Corbett, C. A. Forbes, D. Moro, and A. A. Scalzo
Extensive sequence variation exists among isolates of murine cytomegalovirus within members of the m02 family of genes
J. Gen. Virol.,
March 1, 2007;
88(3):
758 - 769.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. M. Kantarjian, F. Giles, A. Quintas-Cardama, and J. Cortes
Important Therapeutic Targets in Chronic Myelogenous Leukemia
Clin. Cancer Res.,
February 15, 2007;
13(4):
1089 - 1097.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Taschner, C. Koesters, B. Platzer, A. Jorgl, W. Ellmeier, T. Benesch, and H. Strobl
Down-regulation of RXR{alpha} expression is essential for neutrophil development from granulocyte/monocyte progenitors
Blood,
February 1, 2007;
109(3):
971 - 979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Jankovic, A. Ciarrocchi, P. Boccuni, T. DeBlasio, R. Benezra, and S. D. Nimer
Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells
PNAS,
January 23, 2007;
104(4):
1260 - 1265.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Sherrill and W. E. Miller
G Protein-coupled Receptor (GPCR) Kinase 2 Regulates Agonist-independent Gq/11 Signaling from the Mouse Cytomegalovirus GPCR M33
J. Biol. Chem.,
December 29, 2006;
281(52):
39796 - 39805.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. Skaggs, M. E. Gorre, A. Ryvkin, M. R. Burgess, Y. Xie, Y. Han, E. Komisopoulou, L. M. Brown, J. A. Loo, E. M. Landaw, et al.
Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants
PNAS,
December 19, 2006;
103(51):
19466 - 19471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. G.P. Bumm, C. Elsea, A. S. Corbin, M. Loriaux, D. Sherbenou, L. Wood, J. Deininger, R. T. Silver, B. J. Druker, and M. W.N. Deininger
Characterization of Murine JAK2V617F-Positive Myeloproliferative Disease
Cancer Res.,
December 1, 2006;
66(23):
11156 - 11165.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ma, A. Turetsky, L. Trinh, and R. Lu
IFN Regulatory Factor 4 and 8 Promote Ig Light Chain {kappa} Locus Activation in Pre-B Cell Development
J. Immunol.,
December 1, 2006;
177(11):
7898 - 7904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hu, S. Swerdlow, T. M. Duffy, R. Weinmann, F. Y. Lee, and S. Li
Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
PNAS,
November 7, 2006;
103(45):
16870 - 16875.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Glaser, D. Metcalf, L. Wu, A. H. Hart, L. DiRago, S. Mifsud, A. D'Amico, S. Dagger, C. Campo, A. C. Chan, et al.
Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia
PNAS,
October 31, 2006;
103(44):
16460 - 16465.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. K. Middleton, A. M. Zukas, T. Rubinstein, M. Jacob, P. Zhu, L. Zhao, I. Blair, and E. Pure
Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease
J. Exp. Med.,
October 30, 2006;
203(11):
2529 - 2540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Kim, T. Miwa, and W.-C. Song
Retrovirus-Mediated Over-Expression of Decay-Accelerating Factor Rescues Crry-Deficient Erythrocytes from Acute Alternative Pathway Complement Attack
J. Immunol.,
October 15, 2006;
177(8):
5558 - 5566.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Parikh, R. Subrahmanyam, and R. Ren
Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice
Blood,
October 1, 2006;
108(7):
2349 - 2357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Abtahian, N. Bezman, R. Clemens, E. Sebzda, L. Cheng, S. J. Shattil, M. L. Kahn, and G. A. Koretzky
Evidence for the Requirement of ITAM Domains but Not SLP-76/Gads Interaction for Integrin Signaling in Hematopoietic Cells.
Mol. Cell. Biol.,
September 1, 2006;
26(18):
6936 - 6949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. L. Schweitzer, K. J. Huang, M. B. Kamath, A. V. Emelyanov, B. K. Birshtein, and R. P. DeKoter
Spi-C Has Opposing Effects to PU.1 on Gene Expression in Progenitor B Cells
J. Immunol.,
August 15, 2006;
177(4):
2195 - 2207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. J. Griswold, M. MacPartlin, T. Bumm, V. L. Goss, T. O'Hare, K. A. Lee, A. S. Corbin, E. P. Stoffregen, C. Smith, K. Johnson, et al.
Kinase domain mutants of bcr-abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib.
Mol. Cell. Biol.,
August 1, 2006;
26(16):
6082 - 6093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. R. Garrod, C. K. Chang, F.-C. Liu, T. V. Brennan, R. D. Foster, and S.-M. Kang
Targeted Lymphoid Homing of Dendritic Cells Is Required for Prolongation of Allograft Survival
J. Immunol.,
July 15, 2006;
177(2):
863 - 868.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. T. Ichikawa, M. P. Sowden, A. T. Torelli, J. Bachl, P. Huang, G. S. C. Dance, S. H. Marr, J. Robert, J. E. Wedekind, H. C. Smith, et al.
Structural Phylogenetic Analysis of Activation-Induced Deaminase Function
J. Immunol.,
July 1, 2006;
177(1):
355 - 361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Ye, N. Wolff, L. Li, S. Zhang, and R. L. Ilaria Jr
STAT5 signaling is required for the efficient induction and maintenance of CML in mice
Blood,
June 15, 2006;
107(12):
4917 - 4925.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gao, H. Wang, P. Lee, J. Melamed, C. X Li, F. Zhang, H. Wu, L. Zhou, and Z. Wang
Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland.
J. Mol. Endocrinol.,
June 1, 2006;
36(3):
463 - 483.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Guerzoni, M. Bardini, S. A. Mariani, G. Ferrari-Amorotti, P. Neviani, M. L. Panno, Y. Zhang, R. Martinez, D. Perrotti, and B. Calabretta
Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells
Blood,
May 15, 2006;
107(10):
4080 - 4089.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-G. Wendel, E. de Stanchina, E. Cepero, S. Ray, M. Emig, J. S. Fridman, D. R. Veach, W. G. Bornmann, B. Clarkson, W. R. McCombie, et al.
Loss of p53 impedes the antileukemic response to BCR-ABL inhibition
PNAS,
May 9, 2006;
103(19):
7444 - 7449.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Holmes, S. Carotta, L. M. Corcoran, and S. L. Nutt
Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
Genes & Dev.,
April 15, 2006;
20(8):
933 - 938.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. M. Wang, G. Y. Zhang, Y. Wang, M. Hu, H. Wu, D. Watson, S. Hori, I. E. Alexander, D. C.H. Harris, and S. I. Alexander
Foxp3-Transduced Polyclonal Regulatory T Cells Protect against Chronic Renal Injury from Adriamycin
J. Am. Soc. Nephrol.,
March 1, 2006;
17(3):
697 - 706.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Jordan, J. Sadler, J. E. Austin, L. D. Finkelstein, A. L. Singer, P. L. Schwartzberg, and G. A. Koretzky
Functional Hierarchy of the N-Terminal Tyrosines of SLP-76
J. Immunol.,
February 15, 2006;
176(4):
2430 - 2438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Cui, J. Z. Ke, Q. Zhang, H.-Z. Ke, C. Chalouni, and A. Vignery
The intracellular domain of CD44 promotes the fusion of macrophages
Blood,
January 15, 2006;
107(2):
796 - 805.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Boyd, Y.-Y. Xiao, K. Fan, A. Poholek, N. G. Copeland, N. A. Jenkins, and A. S. Perkins
Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR
Blood,
January 15, 2006;
107(2):
733 - 741.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Dumortier, R. Jeannet, P. Kirstetter, E. Kleinmann, M. Sellars, N. R. dos Santos, C. Thibault, J. Barths, J. Ghysdael, J. A. Punt, et al.
Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice
Mol. Cell. Biol.,
January 1, 2006;
26(1):
209 - 220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Bijangi-Vishehsaraei, M. R. Saadatzadeh, A. Werne, K. A. W. McKenzie, R. Kapur, H. Ichijo, and L. S. Haneline
Enhanced TNF-{alpha}-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1
Blood,
December 15, 2005;
106(13):
4124 - 4130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Zweidler-McKay, Y. He, L. Xu, C. G. Rodriguez, F. G. Karnell, A. C. Carpenter, J. C. Aster, D. Allman, and W. S. Pear
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies
Blood,
December 1, 2005;
106(12):
3898 - 3906.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Barnes, D. Palaiologou, E. Panousopoulou, B. Schultheis, A. S.M. Yong, A. Wong, L. Pattacini, J. M. Goldman, and J. V. Melo
Bcr-Abl Expression Levels Determine the Rate of Development of Resistance to Imatinib Mesylate in Chronic Myeloid Leukemia
Cancer Res.,
October 1, 2005;
65(19):
8912 - 8919.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Feldhahn, P. Rio, B. N. B. Soh, S. Liedtke, M. Sprangers, F. Klein, P. Wernet, H. Jumaa, W.-K. Hofmann, H. Hanenberg, et al.
Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells
PNAS,
September 13, 2005;
102(37):
13266 - 13271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Corradini, V. Cesi, V. Bartella, E. Pani, R. Bussolari, O. Candini, and B. Calabretta
Enhanced Proliferative Potential of Hematopoietic Cells Expressing Degradation-resistant c-Myb Mutants
J. Biol. Chem.,
August 26, 2005;
280(34):
30254 - 30262.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Dileepan, M. S. Kannan, B. Walcheck, P. Thumbikat, and S. K. Maheswaran
Mapping of the Binding Site for Mannheimia haemolytica Leukotoxin within Bovine CD18
Infect. Immun.,
August 1, 2005;
73(8):
5233 - 5237.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Terme, C. Borg, F. Guilhot, C. Masurier, C. Flament, E. F. Wagner, S. Caillat-Zucman, A. Bernheim, A. G. Turhan, A. Caignard, et al.
BCR/ABL Promotes Dendritic Cell-Mediated Natural Killer Cell Activation
Cancer Res.,
July 15, 2005;
65(14):
6409 - 6417.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Grundler, C. Miething, C. Thiede, C. Peschel, and J. Duyster
FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model
Blood,
June 15, 2005;
105(12):
4792 - 4799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Feldhahn, F. Klein, J. L. Mooster, P. Hadweh, M. Sprangers, M. Wartenberg, M. M. Bekhite, W.-K. Hofmann, S. Herzog, H. Jumaa, et al.
Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells
J. Exp. Med.,
June 6, 2005;
201(11):
1837 - 1852.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Cho, M. Melnick, G. P. Solidakis, and P. N. Tsichlis
Tpl2 (Tumor Progression Locus 2) Phosphorylation at Thr290 Is Induced by Lipopolysaccharide via an I{kappa}-B Kinase-{beta}-dependent Pathway and Is Required for Tpl2 Activation by External Signals
J. Biol. Chem.,
May 27, 2005;
280(21):
20442 - 20448.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. C. Wolff, D. R. Veach, W. P. Tong, W. G. Bornmann, B. Clarkson, and R. L. Ilaria Jr
PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemia
Blood,
May 15, 2005;
105(10):
3995 - 4003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Quintas-Cardama, H. Kantarjian, M. Talpaz, S. O'Brien, G. Garcia-Manero, S. Verstovsek, M. B. Rios, K. Hayes, A. Glassman, B. N. Bekele, et al.
Imatinib mesylate therapy may overcome the poor prognostic significance of deletions of derivative chromosome 9 in patients with chronic myelogenous leukemia
Blood,
March 15, 2005;
105(6):
2281 - 2286.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Tang, Y. Li, D. Yu, A. Thomas-Tikhonenko, V. S. Spiegelman, and S. Y. Fuchs
Targeting {beta}-Transducin Repeat-Containing Protein E3 Ubiquitin Ligase Augments the Effects of Antitumor Drugs on Breast Cancer Cells
Cancer Res.,
March 1, 2005;
65(5):
1904 - 1908.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. ZENDER, W. XUE, C. CORDON-CARDO, G.J. HANNON, R. LUCITO, S. POWERS, P. FLEMMING, M.S. SPECTOR, and S.W. LOWE
Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors
Cold Spring Harb Symp Quant Biol,
January 1, 2005;
70(0):
251 - 261.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Koschmieder, B. Gottgens, P. Zhang, J. Iwasaki-Arai, K. Akashi, J. L. Kutok, T. Dayaram, K. Geary, A. R. Green, D. G. Tenen, et al.
Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis
Blood,
January 1, 2005;
105(1):
324 - 334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. W. Harder, C. Quilici, E. Naik, M. Inglese, N. Kountouri, A. Turner, K. Zlatic, D. M. Tarlinton, and M. L. Hibbs
Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1
Blood,
December 15, 2004;
104(13):
3901 - 3910.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. W. H. Yee, M. Schittenhelm, A.-M. O'Farrell, A. R. Town, L. McGreevey, T. Bainbridge, J. M. Cherrington, and M. C. Heinrich
Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells
Blood,
December 15, 2004;
104(13):
4202 - 4209.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Wong, J. McLaughlin, D. Cheng, C. Zhang, K. M. Shokat, and O. N. Witte
Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations
PNAS,
December 14, 2004;
101(50):
17456 - 17461.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Nixon, J. Rajaiya, and C. F. Webb
Mutations in the DNA-binding Domain of the Transcription Factor Bright Act as Dominant Negative Proteins and Interfere with Immunoglobulin Transactivation
J. Biol. Chem.,
December 10, 2004;
279(50):
52465 - 52472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yan, S. A. Burel, L. F. Peterson, E. Kanbe, H. Iwasaki, A. Boyapati, R. Hines, K. Akashi, and D.-E. Zhang
From the Cover: Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development
PNAS,
December 7, 2004;
101(49):
17186 - 17191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. B. Deming, Z. T. Schafer, J. S. Tashker, M. B. Potts, M. Deshmukh, and S. Kornbluth
Bcr-Abl-Mediated Protection from Apoptosis Downstream of Mitochondrial Cytochrome c Release
Mol. Cell. Biol.,
December 1, 2004;
24(23):
10289 - 10299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Ricci, Z. Jin, M. Dews, D. Yu, A. Thomas-Tikhonenko, D. T. Dicker, and W. S. El-Deiry
Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity
Mol. Cell. Biol.,
October 1, 2004;
24(19):
8541 - 8555.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Guo, G. Z. Ferl, R. Deora, M. Riedinger, S. Yin, J. L. Kerwin, J. A. Loo, and O. N. Witte
A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-{gamma} activation
PNAS,
September 28, 2004;
101(39):
14180 - 14185.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ramaraj, H. Singh, N. Niu, S. Chu, M. Holtz, J. K. Yee, and R. Bhatia
Effect of Mutational Inactivation of Tyrosine Kinase Activity on BCR/ABL-Induced Abnormalities in Cell Growth and Adhesion in Human Hematopoietic Progenitors
Cancer Res.,
August 1, 2004;
64(15):
5322 - 5331.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Keller, T. Ezaki, R.-J. Guo, and J. P. Lynch
Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cells
Am J Physiol Gastrointest Liver Physiol,
July 1, 2004;
287(1):
G104 - G114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. P. Million, N. Harakawa, S. Roumiantsev, L. Varticovski, and R. A. Van Etten
A Direct Binding Site for Grb2 Contributes to Transformation and Leukemogenesis by the Tel-Abl (ETV6-Abl) Tyrosine Kinase
Mol. Cell. Biol.,
June 1, 2004;
24(11):
4685 - 4695.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. N. Wu, M. S. Jordan, M. A. Silverman, E. J. Peterson, and G. A. Koretzky
Differential Requirement for Adapter Proteins Src Homology 2 Domain-Containing Leukocyte Phosphoprotein of 76 kDa and Adhesion- and Degranulation-Promoting Adapter Protein in Fc{epsilon}RI Signaling and Mast Cell Function
J. Immunol.,
June 1, 2004;
172(11):
6768 - 6774.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Calabretta and D. Perrotti
The biology of CML blast crisis
Blood,
June 1, 2004;
103(11):
4010 - 4022.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. C. Matte, J. Cormier, B. E. Anderson, I. Athanasiadis, J. Liu, S. G. Emerson, W. Pear, and W. D. Shlomchik
Graft-versus-leukemia in a retrovirally induced murine CML model: mechanisms of T-cell killing
Blood,
June 1, 2004;
103(11):
4353 - 4361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
