|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 92 No. 11 (December 1), 1998:
pp. 4036-4039
The Viral Chemokine Macrophage Inflammatory Protein-II Is a
Selective Th2 Chemoattractant
S. Sozzani,
W. Luini,
G. Bianchi,
P. Allavena,
T.N.C. Wells,
M. Napolitano,
G. Bernardini,
A. Vecchi,
D. D'Ambrosio,
D. Mazzeo,
F. Sinigaglia,
A. Santoni,
E. Maggi,
S. Romagnani, and
A. Mantovani
From the Istituto di Ricerche Farmacologiche `Mario Negri,' Milan;
Section of Pathology and Immunology, Department Biotechnology,
University of Brescia, Brescia, Italy; Serono Pharmaceutical Research
Institute, Geneva, Switzerland; Istitute Dermopatico dell'Immacolata,
Rome; Regina Elena Cancer Institute, Rome; University of Rome "La
Sapienza," Rome; Roche Milano Ricerche, Milan; and Istituto di
Medicina Interna e Immunoallergologia, University of Florence,
Florence, Italy.
Kaposi's sarcoma (KS) lesions are characterized by a prominent
leukocyte infiltrate composed of mononuclear phagocytes and T cells.
KS-associated CD4+ and CD8+ cells showed
predominantly a type II cytokine profile. The CC chemokine viral
macrophage inflammatory protein-II (vMIP-II) encoded by the
KS-associated herpes virus 8 was a selective chemoattractant for T
helper 2 (Th2 cells) and for monocytes, whereas it was inactive on
other leukocytes, including Th1 cells, dendritic cells, and natural
killer (NK) cells. vMIP-II was an agonist for CCR8, a chemokine
receptor selectively expressed on CD4+ and
CD8+ cells with a type II cytokine profile. Hence,
vMIP-II has agonist activity for a chemokine receptor (CCR8), which is
preferentially expressed on polarized Th2 cells. The capacity of
vMIP-II to attract type II T cells selectively is likely to be a
component of the virus strategy to subvert the host immune response.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
Y. B. Choi and J. Nicholas
Autocrine and Paracrine Promotion of Cell Survival and Virus Replication by Human Herpesvirus 8 Chemokines
J. Virol.,
July 1, 2008;
82(13):
6501 - 6513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-Y. Yang, T.-H. Kuo, and L.-P. Ting
Human Hepatitis B Viral e Antigen Interacts with Cellular Interleukin-1 Receptor Accessory Protein and Triggers Interleukin-1 Response
J. Biol. Chem.,
November 10, 2006;
281(45):
34525 - 34536.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. R. Rezaee, C. Cunningham, A. J. Davison, and D. J. Blackbourn
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview
J. Gen. Virol.,
July 1, 2006;
87(7):
1781 - 1804.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kakinuma and S. T. Hwang
Chemokines, chemokine receptors, and cancer metastasis
J. Leukoc. Biol.,
April 1, 2006;
79(4):
639 - 651.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. R. Dewin, J. Catusse, and U. A. Gompels
Identification and Characterization of U83A Viral Chemokine, a Broad and Potent {beta}-Chemokine Agonist for Human CCRs with Unique Selectivity and Inhibition by Spliced Isoform
J. Immunol.,
January 1, 2006;
176(1):
544 - 556.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Paoletti, V. Petkovic, S. Sebastiani, M. G. Danelon, M. Uguccioni, and B. O. Gerber
A rich chemokine environment strongly enhances leukocyte migration and activities
Blood,
May 1, 2005;
105(9):
3405 - 3412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. P. Singh, S. Singh, P. Ravichandran, D. D. Taub, and J. W. Lillard Jr.
Viral Macrophage-Inflammatory Protein-II: A Viral Chemokine That Differentially Affects Adaptive Mucosal Immunity Compared with Its Mammalian Counterparts
J. Immunol.,
November 1, 2004;
173(9):
5509 - 5516.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Rosenkilde, K. A. McLean, P. J. Holst, and T. W. Schwartz
The CXC Chemokine Receptor Encoded by Herpesvirus saimiri, ECRF3, Shows Ligand-regulated Signaling through Gi, Gq, and G12/13 Proteins but Constitutive Signaling Only through Gi and G12/13 Proteins
J. Biol. Chem.,
July 30, 2004;
279(31):
32524 - 32533.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Schaerli, L. Ebert, K. Willimann, A. Blaser, R. S. Roos, P. Loetscher, and B. Moser
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
J. Exp. Med.,
May 3, 2004;
199(9):
1265 - 1275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kanamori, S. Watanabe, R. Honma, M. Kuroda, S. Imai, K. Takada, N. Yamamoto, Y. Nishiyama, and Y. Kawaguchi
Epstein-Barr Virus Nuclear Antigen Leader Protein Induces Expression of Thymus- and Activation-Regulated Chemokine in B Cells
J. Virol.,
April 15, 2004;
78(8):
3984 - 3993.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nakayama, K. Hieshima, D. Nagakubo, E. Sato, M. Nakayama, K. Kawa, and O. Yoshie
Selective Induction of Th2-Attracting Chemokines CCL17 and CCL22 in Human B Cells by Latent Membrane Protein 1 of Epstein-Barr Virus
J. Virol.,
February 15, 2004;
78(4):
1665 - 1674.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Murray, P. Symonds, W. Ward, M. Huggins, A. Tiga, K. Rice, Y. M. Heng, I. Todd, and R. A. Robins
Colorectal Cancer Cells Induce Lymphocyte Apoptosis by an Endothelial Monocyte-Activating Polypeptide-II-Dependent Mechanism
J. Immunol.,
January 1, 2004;
172(1):
274 - 281.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Najarro, H.-J. Lee, J. Fox, J. Pease, and G. L. Smith
Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1
J. Gen. Virol.,
December 1, 2003;
84(12):
3325 - 3336.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Dourmishev, A. L. Dourmishev, D. Palmeri, R. A. Schwartz, and D. M. Lukac
Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis
Microbiol. Mol. Biol. Rev.,
June 1, 2003;
67(2):
175 - 212.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Spinetti, G. Bernardini, G. Camarda, A. Mangoni, A. Santoni, M. C. Capogrossi, and M. Napolitano
The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway
J. Leukoc. Biol.,
January 1, 2003;
73(1):
201 - 207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Liu, Y. Okruzhnov, H. Li, and J. Nicholas
Human Herpesvirus 8 (HHV-8)-Encoded Cytokines Induce Expression of and Autocrine Signaling by Vascular Endothelial Growth Factor (VEGF) in HHV-8-Infected Primary-Effusion Lymphoma Cell Lines and Mediate VEGF-Independent Antiapoptotic Effects
J. Virol.,
November 15, 2001;
75(22):
10933 - 10940.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Zhou, Z. Luo, J. Luo, D. Liu, J. W. Hall, R. J. Pomerantz, and Z. Huang
Structural and Functional Characterization of Human CXCR4 as a Chemokine Receptor and HIV-1 Co-receptor by Mutagenesis and Molecular Modeling Studies
J. Biol. Chem.,
November 9, 2001;
276(46):
42826 - 42833.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Chensue
Molecular Machinations: Chemokine Signals in Host-Pathogen Interactions
Clin. Microbiol. Rev.,
October 1, 2001;
14(4):
821 - 835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Iellem, M. Mariani, R. Lang, H. Recalde, P. Panina-Bordignon, F. Sinigaglia, and D. D'Ambrosio
Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors CCR4 and CCR8 by CD4+CD25+ Regulatory T Cells
J. Exp. Med.,
September 17, 2001;
194(6):
847 - 854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. R. Luttichau, J. Gerstoft, and T. W. Schwartz
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8
J. Leukoc. Biol.,
August 1, 2001;
70(2):
277 - 282.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Chensue, N. W. Lukacs, T.-Y. Yang, X. Shang, K. A. Frait, S. L. Kunkel, T. Kung, M. T. Wiekowski, J. A. Hedrick, D. N. Cook, et al.
Aberrant In Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in CC Chemokine Receptor 8 Knockout Mice
J. Exp. Med.,
February 26, 2001;
193(5):
573 - 584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. de Paulis, R. De Palma, L. Di Gioia, M. Carfora, N. Prevete, G. Tosi, R. S. Accolla, and G. Marone
Tat Protein Is an HIV-1-Encoded {beta}-Chemokine Homolog That Promotes Migration and Up-Regulates CCR3 Expression on Human Fc{epsilon}RI+ Cells
J. Immunol.,
December 15, 2000;
165(12):
7171 - 7179.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Bernardini, G. Spinetti, D. Ribatti, G. Camarda, L. Morbidelli, M. Ziche, A. Santoni, M. C. Capogrossi, and M. Napolitano
I-309 binds to and activates endothelial cell functions and acts as an angiogenic molecule in vivo
Blood,
December 15, 2000;
96(13):
4039 - 4045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Nicholas
Evolutionary aspects of oncogenic herpesviruses
Mol. Pathol.,
October 1, 2000;
53(5):
222 - 237.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Mantovani, P. A. Gray, J. Van Damme, and S. Sozzani
Macrophage-derived chemokine (MDC)
J. Leukoc. Biol.,
September 1, 2000;
68(3):
400 - 404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. van Berkel, J. Barrett, H. L. Tiffany, D. H. Fremont, P. M. Murphy, G. McFadden, S. H. Speck, and H. W. Virgin IV
Identification of a Gammaherpesvirus Selective Chemokine Binding Protein That Inhibits Chemokine Action
J. Virol.,
August 1, 2000;
74(15):
6741 - 6747.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Pharmacol. Rev.,
March 1, 2000;
52(1):
145 - 176.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Stine, C. Wood, M. Hill, A. Epp, C. J. Raport, V. L. Schweickart, Y. Endo, T. Sasaki, G. Simmons, C. Boshoff, et al.
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells
Blood,
February 15, 2000;
95(4):
1151 - 1157.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Cesarman, E. A. Mesri, and M. C. Gershengorn
Viral G Protein-coupled Receptor and Kaposi's Sarcoma: A Model of Paracrine Neoplasia?
J. Exp. Med.,
February 7, 2000;
191(3):
417 - 422.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. R. Luttichau, J. Stine, T. P. Boesen, A. H. Johnsen, D. Chantry, J. Gerstoft, and T. W. Schwartz
A Highly Selective CC Chemokine Receptor (CCR)8 Antagonist Encoded by the Poxvirus Molluscum Contagiosum
J. Exp. Med.,
January 3, 2000;
191(1):
171 - 180.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Saederup, Y. c. Lin, D. J. Dairaghi, T. J. Schall, and E. S. Mocarski
Cytomegalovirus-encoded beta chemokine promotes monocyte-associated viremia in the host
PNAS,
September 14, 1999;
96(19):
10881 - 10886.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Dairaghi, R. A. Fan, B. E. McMaster, M. R. Hanley, and T. J. Schall
HHV8-encoded vMIP-I Selectively Engages Chemokine Receptor CCR8. AGONIST AND ANTAGONIST PROFILES OF VIRAL CHEMOKINES
J. Biol. Chem.,
July 30, 1999;
274(31):
21569 - 21574.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Endres, C. G. Garlisi, H. Xiao, L. Shan, and J. A. Hedrick
The Kaposi's Sarcoma-related Herpesvirus (KSHV)-encoded Chemokine vMIP-I is a Specific Agonist for the CC Chemokine Receptor (CCR)8
J. Exp. Med.,
June 21, 1999;
189(12):
1993 - 1998.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Rosenkilde, T. N. Kledal, P. J. Holst, and T. W. Schwartz
Selective Elimination of High Constitutive Activity or Chemokine Binding in the Human Herpesvirus 8 Encoded Seven Transmembrane Oncogene ORF74
J. Biol. Chem.,
August 18, 2000;
275(34):
26309 - 26315.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Burns, D. J. Dairaghi, M. Deitz, M. Tsang, and T. J. Schall
Comprehensive Mapping of Poxvirus vCCI Chemokine-binding Protein. EXPANDED RANGE OF LIGAND INTERACTIONS AND UNUSUAL DISSOCIATION KINETICS
J. Biol. Chem.,
January 18, 2002;
277(4):
2785 - 2789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
