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Blood, Vol. 92 No. 11 (December 1), 1998:
pp. 4036-4039
The Viral Chemokine Macrophage Inflammatory Protein-II Is a
Selective Th2 Chemoattractant
S. Sozzani,
W. Luini,
G. Bianchi,
P. Allavena,
T.N.C. Wells,
M. Napolitano,
G. Bernardini,
A. Vecchi,
D. D'Ambrosio,
D. Mazzeo,
F. Sinigaglia,
A. Santoni,
E. Maggi,
S. Romagnani, and
A. Mantovani
From the Istituto di Ricerche Farmacologiche `Mario Negri,' Milan;
Section of Pathology and Immunology, Department Biotechnology,
University of Brescia, Brescia, Italy; Serono Pharmaceutical Research
Institute, Geneva, Switzerland; Istitute Dermopatico dell'Immacolata,
Rome; Regina Elena Cancer Institute, Rome; University of Rome "La
Sapienza," Rome; Roche Milano Ricerche, Milan; and Istituto di
Medicina Interna e Immunoallergologia, University of Florence,
Florence, Italy.
Kaposi's sarcoma (KS) lesions are characterized by a prominent
leukocyte infiltrate composed of mononuclear phagocytes and T cells.
KS-associated CD4+ and CD8+ cells showed
predominantly a type II cytokine profile. The CC chemokine viral
macrophage inflammatory protein-II (vMIP-II) encoded by the
KS-associated herpes virus 8 was a selective chemoattractant for T
helper 2 (Th2 cells) and for monocytes, whereas it was inactive on
other leukocytes, including Th1 cells, dendritic cells, and natural
killer (NK) cells. vMIP-II was an agonist for CCR8, a chemokine
receptor selectively expressed on CD4+ and
CD8+ cells with a type II cytokine profile. Hence,
vMIP-II has agonist activity for a chemokine receptor (CCR8), which is
preferentially expressed on polarized Th2 cells. The capacity of
vMIP-II to attract type II T cells selectively is likely to be a
component of the virus strategy to subvert the host immune response.
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