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Blood, Vol. 92 No. 11 (December 1), 1998:
pp. 4128-4137
Cooperative Effects of Growth Factors Involved in the Induction of
Hematopoietic Mesoderm
Tara L. Huber,
Yi Zhou,
Paul E. Mead, and
Leonard I. Zon
From the Division of Hematology/Oncology and Howard Hughes Medical
Institute, Children's Hospital, Harvard Medical School, Boston, MA.
Hematopoietic induction occurs on the ventral side of
Xenopus gastrulae and is thought to be triggered by the growth
factor bone morphogenetic protein 4 (BMP-4). To characterize this
process, we developed a quantitative and sensitive assay for the
induction of erythroid cells from totipotent ectoderm of the embryo.
When high doses of BMP-4 were used in this explant assay, few erythroid cells were detected. In contrast, large numbers of differentiated erythroid cells were induced when ectoderm was treated with BMP-4 and
the mesoderm inducers, activin, or fibroblast growth
factor (FGF). Ectopic expression of GATA-1 also induced abundant
erythroid cells in ectoderm treated with bFGF. This induction of
erythroid cells by GATA-1 was blocked by coexpression with a dominant
negative BMP-4 receptor, showing that GATA-1 requires the BMP signaling cascade to function. These results suggest that BMP-4 requires mesoderm
induction to generate a program of gene expression, which regulates the
specification of hematopoietic mesoderm by GATA factors.
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