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Blood, Vol. 92 No. 11 (December 1), 1998:
pp. 4256-4262
Interleukin-10 Abrogates the Inhibition of Epstein-Barr
Virus-Induced B-Cell Transformation by Memory T-Cell Responses
M.T. Bejarano and
M.G. Masucci
From the Microbiology and Tumor Biology Center, Karolinska
Institutet, Stockholm, Sweden.
In vitro infection of human B lymphocytes by Epstein-Barr virus
(EBV) results in their growth transformation and establishment of
immortalized lymphoblastoid cell lines. The virus was found to encode a
homologue of the pleiotropic cytokine interleukin-10 (IL-10), which has
wide-ranging effects on the immune system. We investigated the effect
of human IL-10 (hIL-10) and viral IL-10 (vIL-10) on EBV-specific
immunological memory, as assessed by the inhibition of EBV-induced
B-cell transformation by the autologous T cells. We found that IL-10
abrogates the inhibitory capacity of T cells. This IL-10 effect is
mediated through suppression of T-cell activation-induced IL-2 and
interferon- production and through a direct enhancement of
EBV-infected B-cell growth.
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