|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 92 No. 12 (December 15), 1998:
pp. 4521-4528
RAPID COMMUNICATION
Progressive and Persistent Downregulation of Surface CXCR4 in
CD4+ T Cells Infected With Human Herpesvirus 7
Paola Secchiero,
Davide Zella,
Oxana Barabitskaja,
Marvin S. Reitz,
Silvano Capitani,
Robert C. Gallo, and
Giorgio Zauli
From the Institute of Human Virology, University of Maryland,
Baltimore, MD; and the Human Anatomy Section, Department of Morphology
and Embriology, University of Ferrara, Ferrara, Italy.
We have previously shown that infection of CD4+ T
lymphocytes with the T-lymphotropic human herpesvirus 7 (HHV-7)
downregulates surface CD4, which represents the high-affinity receptor
for HHV-7. In this study, we report that HHV-7 infection also causes a
progressive loss of the surface CXC-chemokine receptor 4 (CXCR4) in
CD4+ T cells, accompanied by a reduced intracellular
Ca2+ flux and chemotaxis in response to stromal
cell-derived factor-1 (SDF-1), the specific CXCR4 ligand.
Moreover, CXCR4 is downregulated from the surface of HHV-7-infected T
cells independently of CD4. Because intracellular CXCR4 antigen and
mRNA levels are unaffected in productively HHV-7-infected cells, the
downregulation of CXCR4 apparently does not involve a transcritional
block. Since CXCR4 functions in association with CD4 to permit entry of
several human immunodeficiency virus (HIV) isolates, the potential of
HHV-7 to persistently downregulate the surface expression of CXCR4 may provide novel strategies for limiting HIV infection.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
K. Tadagaki, K. Yamanishi, and Y. Mori
Reciprocal roles of cellular chemokine receptors and human herpesvirus 7-encoded chemokine receptors, U12 and U51
J. Gen. Virol.,
May 1, 2007;
88(5):
1423 - 1428.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Secchiero, P. Mirandola, D. Zella, C. Celeghini, A. Gonelli, M. Vitale, S. Capitani, and G. Zauli
Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4+ T cells
Blood,
October 15, 2001;
98(8):
2474 - 2481.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hasegawa, M. Yasukawa, I. Sakai, and S. Fujita
Transcriptional Down-Regulation of CXC Chemokine Receptor 4 Induced by Impaired Association of Transcription Regulator YY1 with c-Myc in Human Herpesvirus 6-Infected Cells
J. Immunol.,
January 15, 2001;
166(2):
1125 - 1131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. T. Valente, C. Chanel, J. Dumonceaux, R. Olivier, S. Marullo, P. Briand, and U. Hazan
CXCR4 Is Down-Regulated in Cells Infected with the CD4-Independent X4 Human Immunodeficiency Virus Type 1 Isolate m7NDK
J. Virol.,
January 1, 2001;
75(1):
439 - 447.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. Mirandola, P. Secchiero, S. Pierpaoli, G. Visani, L. Zamai, M. Vitale, S. Capitani, and G. Zauli
Infection of CD34+ hematopoietic progenitor cells by human herpesvirus 7 (HHV-7)
Blood,
July 1, 2000;
96(1):
126 - 131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhang, S. Hatse, E. De Clercq, and D. Schols
CXC-Chemokine Receptor 4 Is Not a Coreceptor for Human Herpesvirus 7 Entry into CD4+ T Cells
J. Virol.,
February 15, 2000;
74(4):
2011 - 2016.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. J. Orsini, J.-L. Parent, S. J. Mundell, and J. L. Benovic
Trafficking of the HIV Coreceptor CXCR4. ROLE OF ARRESTINS AND IDENTIFICATION OF RESIDUES IN THE C-TERMINAL TAIL THAT MEDIATE RECEPTOR INTERNALIZATION
J. Biol. Chem.,
October 22, 1999;
274(43):
31076 - 31086.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.-M. Huang, M.-F. Chao, M.-Y. Chen, H.-m. Shih, Y.-P. Chiang, C.-Y. Chuang, and C.-Y. Lee
Reciprocal Regulatory Interaction between Human Herpesvirus 8 and Human Immunodeficiency Virus Type 1
J. Biol. Chem.,
April 13, 2001;
276(16):
13427 - 13432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
