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Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Platelet-Endothelial Cell Interactions During Ischemia/Reperfusion: The Role of P-Selectin Steffen Massberg, Georg Enders, Rosmarie Leiderer, Simone Eisenmenger, Dietmar Vestweber, Fritz Krombach, and Konrad Messmer From the Ludwig-Maximilians-University, Institute for Surgical Research, Klinikum Grosshadern, Munich, Germany; and the University of Münster, Department for Molecular Biology of Inflammation, Münster, Germany. Growing evidence supports a pathophysiological role for platelets during the manifestation of postischemic reperfusion injury; in the current study, we investigated the nature and the molecular determinants of platelet-endothelial cell interactions induced by ischemia/reperfusion (I/R). Platelet-endothelium and leukocyte-endothelium interactions after 1 hour of ischemia were monitored in vivo within mouse small intestine. By intravital fluorescence microscopy, we observed that platelets, like leukocytes, roll along or firmly adhere to postischemic microvascular endothelial cells. In contrast, few leukocyte-endothelial cell interactions were detected in sham-operated controls. Monoclonal antibodies against P-selectin significantly attenuated platelet rolling and adherence in response to I/R. To identify whether platelet or endothelial P-selectin plays the major role in mediating postischemic platelet-endothelial cell interactions, P-selectin-deficient or wild-type platelets were transfused into wild-type or P-selectin-deficient mice, respectively. Whereas platelets lacking P-selectin rolled along or adhered to postischemic wild-type endothelium, interactions between wild-type platelets with mutant endothelium were nearly absent, indicating that I/R-induced platelet-endothelium interactions are dependent on the expression of P-selectin by endothelial cells. Concomitantly, P-selectin expression in the intestinal microvasculature was enhanced in response to I/R, whereas no upregulation of P-selectin was observed on circulating platelets. In summary, we provide first in vivo evidence that platelets accumulate in the postischemic microvasculature early after reperfusion via P-selectin-ligand interactions. Platelet recruitment and subsequent activation might play an important role in the pathogenesis of I/R injury. Blood, Vol. 92 No. 2 (July 15), 1998: pp. 507-515 © 1998 by the American Society of Hematology. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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[Abstract] [Full Text] [PDF] M. Gawaz Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium Cardiovasc Res, February 15, 2004; 61(3): 498 - 511. [Abstract] [Full Text] [PDF] S. Massberg, S. Gruner, I. Konrad, M. I. Garcia Arguinzonis, M. Eigenthaler, K. Hemler, J. Kersting, C. Schulz, I. Muller, F. Besta, et al. Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice Blood, January 1, 2004; 103(1): 136 - 142. [Abstract] [Full Text] [PDF] D. D. Wagner and P. C. Burger Platelets in Inflammation and Thrombosis Arterioscler. Thromb. Vasc. Biol., December 1, 2003; 23(12): 2131 - 2137. [Abstract] [Full Text] [PDF] G. Sun, W.-L. Chang, J. Li, S. M. Berney, D. Kimpel, and H. C. van der Heyde Inhibition of Platelet Adherence to Brain Microvasculature Protects against Severe Plasmodium berghei Malaria Infect. Immun., November 1, 2003; 71(11): 6553 - 6561. [Abstract] [Full Text] [PDF] A. Nishiwaki, T. Ueda, S. Ugawa, S. 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Immun., April 1, 2003; 71(4): 1911 - 1918. [Abstract] [Full Text] A. Tailor and D. N. Granger Hypercholesterolemia Promotes P-Selectin-Dependent Platelet-Endothelial Cell Adhesion in Postcapillary Venules Arterioscler. Thromb. Vasc. Biol., April 1, 2003; 23(4): 675 - 680. [Abstract] [Full Text] [PDF] P. C. Manegold, J. Hutter, S. A. Pahernik, K. Messmer, and M. Dellian Platelet-endothelial interaction in tumor angiogenesis and microcirculation Blood, March 1, 2003; 101(5): 1970 - 1976. [Abstract] [Full Text] [PDF] W. H. Cerwinka, D. Cooper, C. F. Krieglstein, C. R. Ross, J. M. McCord, and D. N. Granger Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules Am J Physiol Heart Circ Physiol, February 1, 2003; 284(2): H535 - H541. [Abstract] [Full Text] [PDF] S. Massberg, M. Gawaz, S. Gruner, V. Schulte, I. Konrad, D. Zohlnhofer, U. Heinzmann, and B. Nieswandt A Crucial Role of Glycoprotein VI for Platelet Recruitment to the Injured Arterial Wall In Vivo J. Exp. Med., January 6, 2003; 197(1): 41 - 49. [Abstract] [Full Text] [PDF] K. Nishijima, J. Kiryu, A. Tsujikawa, M. Honjo, A. Nonaka, K. Yamashiro, H. Kamizuru, Y. Ieki, H. Tanihara, Y. Honda, et al. Inhibitory Effects of Antithrombin III on Interactions between Blood Cells and Endothelial Cells during Retinal Ischemia-Reperfusion Injury Invest. Ophthalmol. Vis. Sci., January 1, 2003; 44(1): 332 - 341. [Abstract] [Full Text] [PDF] J. Russell, D. Cooper, A. Tailor, K. Y. Stokes, and D. N. Granger Low venular shear rates promote leukocyte-dependent recruitment of adherent platelets Am J Physiol Gastrointest Liver Physiol, January 1, 2003; 284(1): G123 - G129. [Abstract] [Full Text] [PDF] T. J. M. Molenaar, C. C. M. Appeldoorn, S. A. M. de Haas, I. N. Michon, A. Bonnefoy, M. F. Hoylaerts, H. Pannekoek, T. J. C. van Berkel, J. Kuiper, and E. A. L. Biessen Specific inhibition of P-selectin-mediated cell adhesion by phage display-derived peptide antagonists Blood, November 15, 2002; 100(10): 3570 - 3577. [Abstract] [Full Text] [PDF] S. Massberg, K. Brand, S. Gruner, S. Page, E. Muller, I. Muller, W. Bergmeier, T. Richter, M. Lorenz, I. Konrad, et al. A Critical Role of Platelet Adhesion in the Initiation of Atherosclerotic Lesion Formation J. Exp. Med., October 7, 2002; 196(7): 887 - 896. [Abstract] [Full Text] [PDF] A. Schober, D. Manka, P. von Hundelshausen, Y. Huo, P. Hanrath, I. J. Sarembock, K. Ley, and C. Weber Deposition of Platelet RANTES Triggering Monocyte Recruitment Requires P-Selectin and Is Involved in Neointima Formation After Arterial Injury Circulation, September 17, 2002; 106(12): 1523 - 1529. [Abstract] [Full Text] [PDF] C. Kupatt, R. Wichels, J. Horstkotte, F. Krombach, H. Habazettl, and P. Boekstegers Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion J. Leukoc. Biol., September 1, 2002; 72(3): 455 - 461. [Abstract] [Full Text] [PDF] A. Khandoga, G. Enders, P. Biberthaler, and F. Krombach Poly(ADP-ribose) polymerase triggers the microvascular mechanisms of hepatic ischemia-reperfusion injury Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G553 - G560. [Abstract] [Full Text] [PDF] W. H. Cerwinka, D. Cooper, C. F. Krieglstein, M. Feelisch, and D. N. Granger Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H1111 - H1117. [Abstract] [Full Text] [PDF] J. A. Barrabes, D. Garcia-Dorado, M. Mirabet, R.-M. Lidon, B. Soriano, M. Ruiz-Meana, P. Pizcueta, J. Blanco, Y. Puigfel, and J. Soler-Soler Lack of effect of glycoprotein IIb/IIIa blockade on myocardial platelet or polymorphonuclear leukocyte accumulation and on infarct size after transient coronary occlusion in pigs J. Am. Coll. Cardiol., January 2, 2002; 39(1): 157 - 165. [Abstract] [Full Text] [PDF] J. W. Salter, C. F. Krieglstein, A. C. Issekutz, and D. N. Granger Platelets modulate ischemia/reperfusion-induced leukocyte recruitment in the mesenteric circulation Am J Physiol Gastrointest Liver Physiol, December 1, 2001; 281(6): G1432 - G1439. [Abstract] [Full Text] [PDF] K. SINGBARTL, S. B. FORLOW, and K. LEY Platelet, but not endothelial, P-selectin is critical for neutrophil-mediated acute postischemic renal failure FASEB J, November 1, 2001; 15(13): 2337 - 2344. [Abstract] [Full Text] [PDF] M. Morigi, M. Galbusera, E. Binda, B. Imberti, S. Gastoldi, A. Remuzzi, C. Zoja, and G. Remuzzi Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress Blood, September 15, 2001; 98(6): 1828 - 1835. [Abstract] [Full Text] [PDF] K. Nishijima, J. Kiryu, A. Tsujikawa, M. Honjo, A. Nonaka, K. Yamashiro, H. Tanihara, S. J. Tojo, Y. Ogura, and Y. Honda In Vivo Evaluation of Platelet-Endothelial Interactions after Transient Retinal Ischemia Invest. Ophthalmol. Vis. Sci., August 1, 2001; 42(9): 2102 - 2109. [Abstract] [Full Text] [PDF] N. Nagai, M. De Mol, B. Van Hoef, M. Verstreken, and D. Collen Depletion of circulating {alpha}2-antiplasmin by intravenous plasmin or immunoneutralization reduces focal cerebral ischemic injury in the absence of arterial recanalization Blood, May 15, 2001; 97(10): 3086 - 3092. [Abstract] [Full Text] [PDF] T. Dickfeld, E. Lengyel, A. E May, S. Massberg, K. Brand, S. Page, C. Thielen, K. Langenbrink, and M. Gawaz Transient interaction of activated platelets with endothelial cells induces expression of monocyte-chemoattractant protein-1 via a p38 mitogen-activated protein kinase mediated pathway: Implications for atherogenesis Cardiovasc Res, January 1, 2001; 49(1): 189 - 199. [Abstract] [Full Text] [PDF] A. M. Lefer Platelets : Unindicted Coconspirators in Inflammatory Tissue Injury Circ. Res., December 8, 2000; 87(12): 1077 - 1078. [Full Text] [PDF] J. Carvalho-Tavares, M. J. Hickey, J. Hutchison, J. Michaud, I. T. Sutcliffe, and P. Kubes A Role for Platelets and Endothelial Selectins in Tumor Necrosis Factor-{alpha}-Induced Leukocyte Recruitment in the Brain Microvasculature Circ. Res., December 8, 2000; 87(12): 1141 - 1148. [Abstract] [Full Text] [PDF] P. Andre, C. V. Denis, J. Ware, S. Saffaripour, R. O. Hynes, Z. M. Ruggeri, and D. D. Wagner Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins Blood, November 15, 2000; 96(10): 3322 - 3328. [Abstract] [Full Text] [PDF] C. Kupatt, H. Habazettl, P. Hanusch, R. Wichels, D. Hahnel, B. F. Becker, and P. Boekstegers c7E3Fab Reduces Postischemic Leukocyte-Thrombocyte Interaction Mediated by Fibrinogen : Implications for Myocardial Reperfusion Injury Arterioscler. Thromb. Vasc. Biol., October 1, 2000; 20(10): 2226 - 2232. [Abstract] [Full Text] [PDF] A. Tsujikawa, J. Kiryu, K. Yamashiro, A. Nonaka, K. Nishijima, Y. Honda, and Y. Ogura Interactions Between Blood Cells and Retinal Endothelium in Endotoxic Sepsis Hypertension, August 1, 2000; 36(2): 250 - 258. [Abstract] [Full Text] [PDF] T. Katayama, Y. Ikeda, M. Handa, T. Tamatani, S. Sakamoto, M. Ito, Y. Ishimura, and M. Suematsu Immunoneutralization of Glycoprotein Ib{alpha} Attenuates Endotoxin-Induced Interactions of Platelets and Leukocytes With Rat Venular Endothelium In Vivo Circ. Res., May 26, 2000; 86(10): 1031 - 1037. [Abstract] [Full Text] [PDF] P. S. Frenette, C. V. Denis, L. Weiss, K. Jurk, S. Subbarao, B. Kehrel, J. H. Hartwig, D. Vestweber, and D. D. Wagner P-Selectin Glycoprotein Ligand 1 (PSGL-1) Is Expressed on Platelets and Can Mediate Platelet-Endothelial Interactions In Vivo J. Exp. Med., April 18, 2000; 191(8): 1413 - 1422. [Abstract] [Full Text] [PDF] M. Kakutani, T. Masaki, and T. Sawamura A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 PNAS, January 4, 2000; 97(1): 360 - 364. [Abstract] [Full Text] [PDF] S. Massberg, G. Enders, F. C. d. M. Matos, L. I. D. Tomic, R. Leiderer, S. Eisenmenger, K. Messmer, and F. Krombach Fibrinogen Deposition at the Postischemic Vessel Wall Promotes Platelet Adhesion During Ischemia-Reperfusion In Vivo Blood, December 1, 1999; 94(11): 3829 - 3838. [Abstract] [Full Text] [PDF] F.-J. Neumann, D. Zohlnhofer, L. Fakhoury, I. Ott, M. Gawaz, and A. Schomig Effect of glycoprotein IIb/IIIa receptor blockade on platelet-leukocyte interaction and surface expression of the leukocyte integrin Mac-1 in acute myocardial infarction J. Am. Coll. Cardiol., November 1, 1999; 34(5): 1420 - 1426. [Abstract] [Full Text] [PDF] A. Tsujikawa, J. Kiryu, A. Nonaka, K. Yamashiro, H. Nishiwaki, S. J. Tojo, Y. Ogura, and Y. Honda In Vivo Evaluation of Platelet-Endothelial Interactions in Retinal Microcirculation of Rats Invest. Ophthalmol. Vis. Sci., November 1, 1999; 40(12): 2918 - 2924. [Abstract] [Full Text] [PDF] G. M. Romo, J.-F. Dong, A. J. Schade, E. E. Gardiner, G. S. Kansas, C. Q. Li, L. V. McIntire, M. C. Berndt, and J. A. Lopez The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin J. Exp. Med., September 20, 1999; 190(6): 803 - 814. [Abstract] [Full Text] [PDF] E. von Dobschuetz, T. Hoffmann, and K. Messmer Inhibition of Neutrophil Proteinases by Recombinant Serpin Lex032 Reduces Capillary No-Reflow in Ischemia/Reperfusion-Induced Acute Pancreatitis J. Pharmacol. Exp. Ther., August 1, 1999; 290(2): 782 - 788. [Abstract] [Full Text] T. Bombeli, B. R. Schwartz, and J. M. Harlan Endothelial Cells Undergoing Apoptosis Become Proadhesive for Nonactivated Platelets Blood, June 1, 1999; 93(11): 3831 - 3838. [Abstract] [Full Text] [PDF] S. Massberg, M. Sausbier, P. Klatt, M. Bauer, A. Pfeifer, W. Siess, R. Fassler, P. Ruth, F. Krombach, and F. Hofmann Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3',5'-Monophosphate Kinase I J. Exp. Med., April 19, 1999; 189(8): 1255 - 1264. [Abstract] [Full Text] [PDF]

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