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Blood, Vol. 92 No. 3 (August 1), 1998:
pp. 1062-1069
Release of Polymorphonuclear Leukocytes From the Bone Marrow by
Interleukin-8
Takeshi Terashima,
Dean English,
James C. Hogg, and
Stephan F. vanEeden
From the Pulmonary Research Laboratory, University of British
Columbia, St. Paul's Hospital, Vancouver, Canada.
Several studies have shown that interleukin-8 (IL-8) causes a rapid
granulocytosis with the release of polymorphonuclear leukocytes (PMN)
from the bone marrow (BM) partially responsible for the granulocytosis.
This study was designed to quantitate the release of PMN from the BM by
IL-8 and measure the transit time of PMN through the marrow after IL-8
administration. The thymidine analogue, 5'-bromo-2'-deoxyuridine
(BrdU), was used to label dividing PMN in the marrow and follow their
release into the circulation after intravenous IL-8. This allowed us to
calculate the transit time of PMN through the mitotic and postmitotic
pools of BM. BrdU was infused intravenously into rabbits 24 hours
before IL-8 (2.5 µg/kg). IL-8 caused a rapid, transient
granulocytopenia (5.9 ± 0.4 at baseline v 0.2 ± 0.06 × 10/9L at 5 minutes, P < .05) followed
by granulocytosis (8.4 ± 0.1 at 30 minutes, P < .05)
associated with an increased number (0.3 ± 0.1 at baseline v
1.2 ± 0.6 × 109/L at 30 minutes, P < .05) and
percentage of band cells (P < .05), as well as a rapid
increase in the number of BrdU-labeled PMN (PMNBrdU) in the
circulation (0.09 ± 0.05 at baseline to 1.5 ± 0.6 × 109/L at 60 minutes, P < .05). The transit time
of PMN through both the mitotic and postmitotic pools of BM was not
affected by IL-8. To determine the marrow compartment from which the
PMN were mobilized by IL-8, we quantitated PMN movement from the
hematopoietic and sinusoidal compartments into the circulation. The
fraction of PMNBrdU in both compartments was higher than in
the circulating blood (P < .05) and the fraction and number
of PMNBrdU in the sinusoids decreased with IL-8 treatment
(P < .05). We conclude that the pool of PMN residing in the
BM venous sinusoids are rapidly released into the circulation after
administration of IL-8.
© 1998 by The American Society of Hematology.
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