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Blood, Vol. 92 No. 3 (August 1), 1998: pp. 834-841

Mutual Education Between Hematopoietic Cells and Bone Marrow Stromal Cells Through Direct Cell-to-Cell Contact: Factors That Determine the Growth of Bone Marrow Stroma-Dependent Leukemic (HB-1) Cells

Huijie Jiang, Kenkichi Sugimoto, Hitoshi Sawada, Emi Takashita, Maki Tohma, Hiroyuki Gonda, and Kazuhiro John Mori

From the Department of Molecular and Cellular Biology, Faculty of Science, Niigata University, Niigata; and the Department of Internal Medicine, Kokura Memorial Hospital, Kokurakitaku, Kitakyushu, Japan.

A stroma-dependent cell line (HB-1) was established from myelogenous leukemic cells of CBA/N mouse. Characterization of the cells showed that HB-1 proliferated on hematopoietic supportive stromal cells (MS-10), but did not survive or proliferate on hematopoietic nonsupportive cells (MS-K). Direct contact between HB-1 and MS-10 appears to be necessary for HB-1 to proliferate on MS-10. We found that interleukin-1alpha (IL-1alpha ) produced by MS-10 plays a major role in the survival and proliferation of HB-1. IL-11 did not support the proliferation of HB-1 cells by itself, but enhanced the proliferation of HB-1 cells in the presence of IL-1alpha . The expression of IL-1alpha and IL-11 was induced in MS-10 by the direct contact with HB-1 cells, and the expression of IL-1 receptor type I (IL-1RI) and interleukin-11 receptor (IL-11R) was induced in HB-1 cells by the attachment of the cells to MS-10. These findings show the existence of two-way interactions between HB-1 and MS-10.

© 1998 by The American Society of Hematology.


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