|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 92 No. 4 (August 15), 1998:
pp. 1342-1349
Tissue Inhibitor of Metalloproteinase (TIMP)-1 Induces
Differentiation and an Antiapoptotic Phenotype in Germinal Center B
Cells
Liliana Guedez,
Laurel Courtemanch, and
Maryalice Stetler-Stevenson
From the Hematopathology Section, Laboratory of Pathology, National
Cancer Institute, Bethesda, MD.
Tissue inhibitors of metalloproteinases (TIMPs) have been shown to
be multifunctional factors. Contrasting with their enzyme-inhibitory activity, TIMPs also promote cell growth. Previously, we have reported
an enhanced expression of TIMP-1 by normal reactive B cells and
high-grade lymphomas. In the present study, a series of Burkitt's
lymphoma (BL) cell lines were analyzed for their expression of TIMP-1.
TIMP-1 expression correlates with upregulation of activation and
survival markers. TIMP-1-negative cells express the phenotype
associated with group I BL lines and Epstein-Barr virus (EBV)-negative,
nonendemic BLs (CD10+, CD38+,
sIg+, and CD77+). However,
TIMP-1+ BL lines showed group II/III BL phenotype,
downregulation of the above markers, and upregulation and secretion of
the activation marker CD23. Also, TIMP-1+ cells have high
levels of CD40 expression. To determine whether TIMP-1 is directly
involved in the BL phenotype, an EBV-negative BL line JD38 was infected
with timp-1-expressing retrovirus and analyzed. In the absence
of EBV, upregulation of TIMP-1 is sufficient to induce the same
phenotype seen in TIMP-1+, EBV+ BL lines
(CD10 , CD38, sIg,
CD77, CD23+, CD40 bright). This study not
only suggests a role for TIMP-1 in BLs, but also supports its value as
a prognostic factor.
This is a US government work. There are no restrictions on its use.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
K.-H. Kang, S.-Y. Park, S. B. Rho, and J.-H. Lee
Tissue inhibitor of metalloproteinases-3 interacts with angiotensin II type 2 receptor and additively inhibits angiogenesis
Cardiovasc Res,
July 1, 2008;
79(1):
150 - 160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Thaysen-Andersen, I. B. Thogersen, H. J. Nielsen, U. Lademann, N. Brunner, J. J. Enghild, and P. Hojrup
Rapid and Individual-specific Glycoprofiling of the Low Abundance N-Glycosylated Protein Tissue Inhibitor of Metalloproteinases-1
Mol. Cell. Proteomics,
April 1, 2007;
6(4):
638 - 647.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Verstappen and J.W. Von den Hoff
Tissue Inhibitors of Metalloproteinases (TIMPs): Their Biological Functions and Involvement in Oral Disease.
J. Dent. Res.,
December 1, 2006;
85(12):
1074 - 1084.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Kundu, A. K. Mukhopadhyay, R. Patra, A. Banerjee, D. E. Berg, and S. Swarnakar
Cag Pathogenicity Island-independent Up-regulation of Matrix Metalloproteinases-9 and -2 Secretion and Expression in Mice by Helicobacter pylori Infection
J. Biol. Chem.,
November 10, 2006;
281(45):
34651 - 34662.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-B. Park, J.-K. Lee, S.-J. Park, and K. D. Riew
Hypertrophy of Ligamentum Flavum in Lumbar Spinal Stenosis Associated with Increased Proteinase Inhibitor Concentration
J. Bone Joint Surg. Am.,
December 1, 2005;
87(12):
2750 - 2757.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Guedez, A. Martinez, S. Zhao, A. Vivero, S. Pittaluga, M. Stetler-Stevenson, M. Raffeld, and W. G. Stetler-Stevenson
Tissue inhibitor of metalloproteinase 1 (TIMP-1) promotes plasmablastic differentiation of a Burkitt lymphoma cell line: implications in the pathogenesis of plasmacytic/plasmablastic tumors
Blood,
February 15, 2005;
105(4):
1660 - 1668.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-W. Liu, M. E. Taube, K.-K. Jung, Z. Dong, Y. J. Lee, S. Roshy, B. F. Sloane, R. Fridman, and H.-R. C. Kim
Tissue Inhibitor of Metalloproteinase-1 Protects Human Breast Epithelial Cells from Extrinsic Cell Death: A Potential Oncogenic Activity of Tissue Inhibitor of Metalloproteinase-1
Cancer Res.,
February 1, 2005;
65(3):
898 - 906.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Lovelock, A. H. Baker, F. Gao, J.-F. Dong, A. L. Bergeron, W. McPheat, N. Sivasubramanian, and D. L. Mann
Heterogeneous effects of tissue inhibitors of matrix metalloproteinases on cardiac fibroblasts
Am J Physiol Heart Circ Physiol,
February 1, 2005;
288(2):
H461 - H468.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yamazaki, T. Akahane, T. Buck, H. Yoshiji, D. E. Gomez, D. J. Schoeffner, E. Okajima, S. R. Harris, O. R. Bunce, S. S. Thorgeirsson, et al.
Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice
Carcinogenesis,
September 1, 2004;
25(9):
1735 - 1746.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Noel, C Maillard, N Rocks, M Jost, V Chabottaux, N E Sounni, E Maquoi, D Cataldo, and J M Foidart
Membrane associated proteases and their inhibitors in tumour angiogenesis
J. Clin. Pathol.,
June 1, 2004;
57(6):
577 - 584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Lai, G. Z. Rassidakis, L. J. Medeiros, L. Ramdas, A. H. Goy, C. Cutler, Y. Fujio, K. Kunisada, H. M. Amin, and F. Gilles
Signal Transducer and Activator of Transcription-3 Activation Contributes to High Tissue Inhibitor of Metalloproteinase-1 Expression in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma
Am. J. Pathol.,
June 1, 2004;
164(6):
2251 - 2258.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Boyum, E. K. Fellinger, J. D. Schmoker, L. Trombley, K. McPartland, F. P. Ittleman, and A. B. Howard
Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves
J. Thorac. Cardiovasc. Surg.,
March 1, 2004;
127(3):
686 - 691.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Fernandez, C. Butterfield, G. Jackson, and M. A. Moses
Structural and Functional Uncoupling of the Enzymatic and Angiogenic Inhibitory Activities of Tissue Inhibitor of Metalloproteinase-2 (TIMP-2): LOOP 6 IS A NOVEL ANGIOGENESIS INHIBITOR
J. Biol. Chem.,
October 17, 2003;
278(42):
40989 - 40995.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-W. Liu, M. M. Bernardo, R. Fridman, and H.-R. C. Kim
Tissue Inhibitor of Metalloproteinase-1 Protects Human Breast Epithelial Cells Against Intrinsic Apoptotic Cell Death via the Focal Adhesion Kinase/Phosphatidylinositol 3-Kinase and MAPK Signaling Pathway
J. Biol. Chem.,
October 10, 2003;
278(41):
40364 - 40372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Visse and H. Nagase
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry
Circ. Res.,
May 2, 2003;
92(8):
827 - 839.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Castoldi, C. R. T. di Gioia, F. Pieruzzi, C. D'Orlando, W. M. M. van de Greef, G. Busca, G. Sperti, and A. Stella
ANG II increases TIMP-1 expression in rat aortic smooth muscle cells in vivo
Am J Physiol Heart Circ Physiol,
February 1, 2003;
284(2):
H635 - H643.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bond, G. Murphy, M. R. Bennett, A. C. Newby, and A. H. Baker
Tissue Inhibitor of Metalloproteinase-3 Induces a Fas-associated Death Domain-dependent Type II Apoptotic Pathway
J. Biol. Chem.,
April 12, 2002;
277(16):
13787 - 13795.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Oelmann, H. Herbst, M. Zuhlsdorf, O. Albrecht, A. Nolte, C. Schmitmann, O. Manzke, V. Diehl, H. Stein, and W. E. Berdel
Tissue inhibitor of metalloproteinases 1 is an autocrine and paracrine survival factor, with additional immune-regulatory functions, expressed by Hodgkin/Reed-Sternberg cells
Blood,
January 1, 2002;
99(1):
258 - 267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. K. Narla, Y. Dong, D. Klis, and F. M. Uckun
Bis(4,7-dimethyl-1,10-phenanthroline) Sulfatooxovanadium(IV) as a Novel Antileukemic Agent with Matrix Metalloproteinase Inhibitory Activity
Clin. Cancer Res.,
April 1, 2001;
7(4):
1094 - 1101.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. Yan and M. A. Moses
A Case of Tumor Betrayal : Biphasic Effects of TIMP-1 on Burkitt's Lymphoma
Am. J. Pathol.,
April 1, 2001;
158(4):
1185 - 1190.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Guedez, A. J. McMarlin, D. W. Kingma, T. A. Bennett, M. Stetler-Stevenson, and W. G. Stetler-Stevenson
Tissue Inhibitor of Metalloproteinase-1 Alters the Tumorigenicity of Burkitt's Lymphoma via Divergent Effects on Tumor Growth and Angiogenesis
Am. J. Pathol.,
April 1, 2001;
158(4):
1207 - 1215.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Guedez, A. Mansoor, B. Birkedal-Hansen, M. S. Lim, P. Fukushima, D. Venzon, W. G. Stetler-Stevenson, and M. Stetler-Stevenson
Tissue inhibitor of metalloproteinases 1 regulation of interleukin-10 in B-cell differentiation and lymphomagenesis
Blood,
March 15, 2001;
97(6):
1796 - 1802.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Trim, S. K. Samra, M. J. P. Arthur, M. C. Wright, M. McAulay, R. Beri, and D. A. Mann
Upstream Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Element-1, a Novel and Essential Regulatory DNA Motif in the Human TIMP-1 Gene Promoter, Directly Interacts with a 30-kDa Nuclear Protein
J. Biol. Chem.,
February 25, 2000;
275(9):
6657 - 6663.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Li, R. Fridman, and H.-R. C. Kim
Tissue Inhibitor of Metalloproteinase-1 Inhibits Apoptosis of Human Breast Epithelial Cells
Cancer Res.,
December 1, 1999;
59(24):
6267 - 6275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Kossakowska, D. R. Edwards, C. Prusinkiewicz, M. C. Zhang, D. Guo, S. J. Urbanski, T. Grogan, L. A. Marquez, and A. Janowska-Wieczorek
Interleukin-6 Regulation of Matrix Metalloproteinase (MMP-2 and MMP-9) and Tissue Inhibitor of Metalloproteinase (TIMP-1) Expression in Malignant Non-Hodgkin's Lymphomas
Blood,
September 15, 1999;
94(6):
2080 - 2089.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. T. Wingfield, J. K. Sax, S. J. Stahl, J. Kaufman, I. Palmer, V. Chung, M. L. Corcoran, D. E. Kleiner, and W. G. Stetler-Stevenson
Biophysical and Functional Characterization of Full-length, Recombinant Human Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Produced in Escherichia coli. COMPARISON OF WILD TYPE AND AMINO-TERMINAL ALANINE APPENDED VARIANT WITH IMPLICATIONS FOR THE MECHANISM OF TIMP FUNCTIONS
J. Biol. Chem.,
July 23, 1999;
274(30):
21362 - 21368.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Price, C. Dennison, H. Tschesche, and E. Elliott
Neutrophil Tissue Inhibitor of Matrix Metalloproteinases-1 Occurs in Novel Vesicles That Do Not Fuse with the Phagosome
J. Biol. Chem.,
September 1, 2000;
275(36):
28308 - 28315.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Ikari, E. Mulvihill, and S. M. Schwartz
alpha 1-Proteinase Inhibitor, alpha 1-Antichymotrypsin, and alpha 2-Macroglobulin Are the Antiapoptotic Factors of Vascular Smooth Muscle Cells
J. Biol. Chem.,
April 6, 2001;
276(15):
11798 - 11803.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
