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Blood, Vol. 92 No. 4 (August 15), 1998:
pp. 1432-1441
Expression Profile of Active Genes in Granulocytes
Koichi Itoh,
Kousaku Okubo,
Hiroyasu Utiyama,
Tetsuo Hirano,
Junji Yoshii, and
Kenichi Matsubara
From the Institute for Molecular and Cellular Biology, Osaka
University, Yamada-oka, Suita, Osaka, Japan; the Life Science Group,
Faculty of Integrated Arts and Sciences, Hiroshima University,
Kagamiyama, Higashihiroshima, Hiroshima, Japan; and Hitachi Software
Engineering, Co, Ltd, Onoe-chou, Naka-ku, Yokohama, Japan.
A number of genes active in granulocytes have been intensively
studied as to the function of their products and their expression controls. However, the intensities and relative order of these gene
activities have not been studied. This report describes an expression
profile of 748 different species of active genes in human peripheral
granulocytes obtained by analyzing a 3 -directed cDNA library
that faithfully represents the mRNA population in the source cells. A
significant fraction (20.3% of the total) of the expressed genes in
granulocytes consisted of nuclear proteins such as DNA binding
proteins, of secretory proteins such as cytokines, and of membrane
proteins such as major histocompatibility complex (MHC)
proteins and receptors. By comparing this expression profile with 11 profiles similarly obtained with unrelated human cells/tissues, we
discovered 10 novel genes that are likely to act specifically in
granulocytes. Comparison of this expression profile with that obtained
with granulocytoids widely used as a granulocyte model by inducing a
cultured promyelocytic leukemia cell line HL60 showed similarities and
dissimilarities of gene expressions.
© 1998 by The American Society of Hematology.
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