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Blood, Vol. 92 No. 8 (October 15), 1998:
pp. 2771-2776
Polymorphisms of Platelet Membrane Glycoprotein Ib Associated
With Arterial Thrombotic Disease
Rocio Gonzalez-Conejero,
Maria L. Lozano,
Jose Rivera,
Javier Corral,
Juan A. Iniesta,
Jose M. Moraleda, and
Vicente Vicente
From the Unit of Hematology and Hemotherapy, and the Department of
Neurology, School of Medicine. Hospital General Universitario, Murcia,
Spain.
Platelet membrane glycoprotein Ib (GPIb) is a major receptor
for von Willebrand factor and thrombin, which plays a key role in the
initial development of thrombi. Two polymorphisms (HPA-2 and VNTR) that
affect phenotype have been described in GPIb. The relevance of these
polymorphisms to thrombotic disease was investigated by genotypic
identification in three case-control studies: 104 case patients with
acute cerebrovascular disease (CVD), 101 case patients with acute
coronary heart disease (CHD), 95 patients with deep venous thrombosis
(DVT), and one control age-, sex-, and race-matched for each case
patient. Results show that the C/B genotype of the VNTR and the HPA-2b
polymorphisms of GPIb are strongly associated with increased risk of
coronary heart disease and cerebral vascular disease but not with deep vein thrombosis. These two polymorphisms of GPIb may represent newly
identified risk factors for arterial thrombotic disease, but not for
venous thrombosis.
© 1998 by The American Society of Hematology.
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