|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 93 No. 1 (January 1), 1999:
pp. 149-156
Selective Transendothelial Migration of Hematopoietic Progenitor
Cells: A Role in Homing of Progenitor Cells
Kiyotoshi Imai,
Masanobu Kobayashi,
Jingxin Wang,
Yoichi Ohiro,
Jun-ichi Hamada,
Yuko Cho,
Masahiro Imamura,
Manabu Musashi,
Takeshi Kondo,
Masuo Hosokawa, and
Masahiro Asaka
From the Laboratory of Pathology, Laboratory of Cell Biology, Cancer
Institute, the Department of Pediatrics, the Department of Gerontology
and Oncology, The Third Department of Internal Medicine, Hokkaido
University School of Medicine, Sapporo, Japan.
To elucidate the mechanisms by which hematopoietic progenitor cells
transmigrate via the bone marrow (BM) endothelial cells, we first
established endothelial cell lines from BM and lung, and BM fibroblast
cell lines; then we established an in vitro model of transendothelial
migration of hematopoietic progenitor cells in the presence of
chemoattractants secreted by BM fibroblast cells. The BM endothelial
cells expressed vascular cell adhesion molecule-1 (VCAM-1), but the
lung endothelial cells did not. The BM fibroblast cells secreted
chemoattractants including stroma cell-derived factor
(SDF)-1, which could attract hematopoietic progenitor
cells to BM and activate the adhesion molecules expressed on
hematopoietic progenitor cells after rolling along the endothelial cells. Anti-SDF-1 antibody inhibited the transendothelial migration of
a hematopoietic progenitor cell line, FDCP-2. FDCP-2 that expressed very late activation antigen-4 (VLA-4) and normal progenitor cells transmigrated through BM endothelial cells but not lung endothelial cells, even if in the presence of chemoattractants produced by BM
fibroblasts. Both anti-VLA-4 and anti-VCAM-1 antibodies inhibited the
transendothelial migration of FDCP-2 cells and normal hematopoietic progenitor cells. These findings suggest that the transendothelial migration of hematopoietic progenitor cells is characteristic of BM
endothelial cells, and that VLA-4/VCAM-1 and SDF-1 play important roles
in the transendothelial migration and, consequently, homing of
hematopoietic progenitor cells to BM.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Mikami, H. Nakase, S. Yamamoto, Y. Takeda, T. Yoshino, K. Kasahara, S. Ueno, N. Uza, S. Oishi, N. Fujii, et al.
Blockade of CXCL12/CXCR4 Axis Ameliorates Murine Experimental Colitis
J. Pharmacol. Exp. Ther.,
November 1, 2008;
327(2):
383 - 392.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S. Pandit, L. Sikora, G. Muralidhar, S. P. Rao, and P. Sriramarao
Sustained Exposure to Nicotine Leads to Extramedullary Hematopoiesis in the Spleen
Stem Cells,
November 1, 2006;
24(11):
2373 - 2381.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. F. M. Segers, I. Van Riet, L. J. Andries, K. Lemmens, M. J. Demolder, A. J. M. L. De Becker, M. M. Kockx, and G. W. De Keulenaer
Mesenchymal stem cell adhesion to cardiac microvascular endothelium: activators and mechanisms
Am J Physiol Heart Circ Physiol,
April 1, 2006;
290(4):
H1370 - H1377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-G. Kopp, S. T. Avecilla, A. T. Hooper, and S. Rafii
The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization
Physiology,
October 1, 2005;
20(5):
349 - 356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C.W. Zannettino, A. N. Farrugia, A. Kortesidis, J. Manavis, L. B. To, S. K. Martin, P. Diamond, H. Tamamura, T. Lapidot, N. Fujii, et al.
Elevated Serum Levels of Stromal-Derived Factor-1{alpha} Are Associated with Increased Osteoclast Activity and Osteolytic Bone Disease in Multiple Myeloma Patients
Cancer Res.,
March 1, 2005;
65(5):
1700 - 1709.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tavor, I. Petit, S. Porozov, A. Avigdor, A. Dar, L. Leider-Trejo, N. Shemtov, V. Deutsch, E. Naparstek, A. Nagler, et al.
CXCR4 Regulates Migration and Development of Human Acute Myelogenous Leukemia Stem Cells in Transplanted NOD/SCID Mice
Cancer Res.,
April 15, 2004;
64(8):
2817 - 2824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Asosingh, H. De Raeve, E. Menu, I. Van Riet, E. Van Marck, B. Van Camp, and K. Vanderkerken
Angiogenic switch during 5T2MM murine myeloma tumorigenesis: role of CD45 heterogeneity
Blood,
April 15, 2004;
103(8):
3131 - 3137.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Wright, T. L. de Lera, C. Garcia-Moruja, R. Lillo, F. Garcia-Sanchez, A. Caruz, and J. Teixido
Transforming growth factor-{beta}1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion
Blood,
September 15, 2003;
102(6):
1978 - 1984.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Sikora, S. P. Rao, and P. Sriramarao
Selectin-dependent rolling and adhesion of leukocytes in nicotine-exposed microvessels of lung allografts
Am J Physiol Lung Cell Mol Physiol,
September 1, 2003;
285(3):
L654 - L663.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nakao, T. Kuwano, T. Ishibashi, M. Kuwano, and M. Ono
Synergistic Effect of TNF-{alpha} in Soluble VCAM-1-Induced Angiogenesis Through {alpha}4 Integrins
J. Immunol.,
June 1, 2003;
170(11):
5704 - 5711.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. B. Mazo, E. J. Quackenbush, J. B. Lowe, and U. H. von Andrian
Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow
Blood,
May 13, 2002;
99(11):
4182 - 4191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Suzuki, M. Kobayashi, K. Chiba, I. Horiuchi, J. Wang, T. Kondoh, S. Hashino, J. Tanaka, M. Hosokawa, and M. Asaka
Autocrine production of epithelial cell-derived neutrophil attractant-78 induced by granulocyte colony-stimulating factor in neutrophils
Blood,
March 1, 2002;
99(5):
1863 - 1865.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. van Buul, C. Voermans, V. van den Berg, E. C. Anthony, F. P. J. Mul, S. van Wetering, C. E. van der Schoot, and P. L. Hordijk
Migration of Human Hematopoietic Progenitor Cells Across Bone Marrow Endothelium Is Regulated by Vascular Endothelial Cadherin
J. Immunol.,
January 15, 2002;
168(2):
588 - 596.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Papayannopoulou, G. V. Priestley, B. Nakamoto, V. Zafiropoulos, and L. M. Scott
Molecular pathways in bone marrow homing: dominant role of {alpha}4{beta}1 over {beta}2-integrins and selectins
Blood,
October 15, 2001;
98(8):
2403 - 2411.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Khaldoyanidi, L. Sikora, I. Orlovskaya, V. Matrosova, V. Kozlov, and P. Sriramarao
Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal cells
Blood,
July 15, 2001;
98(2):
303 - 312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Hattori, B. Heissig, K. Tashiro, T. Honjo, M. Tateno, J.-H. Shieh, N. R. Hackett, M. S. Quitoriano, R. G. Crystal, S. Rafii, et al.
Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells
Blood,
June 1, 2001;
97(11):
3354 - 3360.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Asosingh, U. Günthert, H. De Raeve, I. Van Riet, B. Van Camp, and K. Vanderkerken
A Unique Pathway in the Homing of Murine Multiple Myeloma Cells: CD44v10 Mediates Binding to Bone Marrow Endothelium
Cancer Res.,
April 1, 2001;
61(7):
2862 - 2865.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. E. Leuker, M. Labow, W. Muller, and N. Wagner
Neonatally Induced Inactivation of the Vascular Cell Adhesion Molecule 1 Gene Impairs B Cell Localization and T Cell-dependent Humoral Immune Response
J. Exp. Med.,
March 19, 2001;
193(6):
755 - 768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Voermans, P.M.L. Rood, P.L. Hordijk, W.R. Gerritsen, and C.E. van der Schoot
Adhesion Molecules Involved in Transendothelial Migration of Human Hematopoietic Progenitor Cells
Stem Cells,
November 1, 2000;
18(6):
435 - 443.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Asosingh, U. Gunthert, M. H. C. Bakkus, H. De Raeve, E. Goes, I. Van Riet, B. Van Camp, and K. Vanderkerken
In Vivo Induction of Insulin-like Growth Factor-I Receptor and CD44v6 Confers Homing and Adhesion to Murine Multiple Myeloma Cells
Cancer Res.,
June 1, 2000;
60(11):
3096 - 3104.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Peled, O. Kollet, T. Ponomaryov, I. Petit, S. Franitza, V. Grabovsky, M. M. Slav, A. Nagler, O. Lider, R. Alon, et al.
The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice
Blood,
June 1, 2000;
95(11):
3289 - 3296.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Naiyer, D.-Y. Jo, J. Ahn, R. Mohle, M. Peichev, G. Lam, R. L. Silverstein, M. A.S. Moore, and S. Rafii
Stromal Derived Factor-1-Induced Chemokinesis of Cord Blood CD34+ Cells (Long-Term Culture-Initiating Cells) Through Endothelial Cells Is Mediated by E-Selectin
Blood,
December 15, 1999;
94(12):
4011 - 4019.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
