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Blood, Vol. 93 No. 1 (January 1), 1999:
pp. 34-42
CC Chemokine Receptors, CCR-1 and CCR-3, Are Potentially Involved
in Antigen-Presenting Cell Function of Human Peripheral
Blood Monocyte-Derived Dendritic Cells
Katsuaki Sato,
Hiroshi Kawasaki,
Hitomi Nagayama,
Ryo Serizawa,
Junji Ikeda,
Chikao Morimoto,
Kunio Yasunaga,
Noboru Yamaji,
Kenji Tadokoro,
Takeo Juji, and
Tsuneo A. Takahashi
From the Department of Cell Processing, Department of Clinical
Immunology and AIDS Research Center, The Institute of Medical Science,
The University of Tokyo, Tokyo, Japan; the Japanese Red Cross Central
Blood Center, Tokyo, Japan; and the Institute for Drug Discovery
Research, Yamanouchi Pharmaceuticals, Co, Ltd, Tsukuba, Japan.
We examined the potential involvement of two CC chemokine receptors
(CCRs), CCR-1 and CCR-3, in the functional activation of
granulocyte-macrophage colony-stimulating factor (GM-CSF) plus interleukin-4 (IL-4)-generated human peripheral blood monocyte-derived immature dendritic cells (DCs). Flow cytometric analysis showed that
CCR-1, CCR-3, CCR-5, and CXC chemokine receptor (CXCR)-4 were expressed
on the cell surface of monocyte-derived DCs. Treatment with a
monoclonal antibody (MoAb) to either CCR-1 or CCR-3 but not MoAbs to
CCR-5 and CXCR-4 abolished chemotactic migration of monocyte-derived
DCs. The DCs treated with either the anti-CCR-1 MoAb or anti-CCR-3
MoAb were less efficient than untreated DCs in proliferation of
allogeneic T cells (TCs) and TC-derived secretion of interferon-
(IFN-). The homotypic aggregation of DCs and heterotypic aggregation
of DCs with TCs were suppressed by the anti-CCR-1 MoAb or anti-CCR-3
MoAb. These results indicate that CCR-1 and CCR-3 specifically regulate
interaction of TCs and DCs in the process of antigen presentation.
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