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Blood, Vol. 93 No. 10 (May 15), 1999:
pp. 3233-3240
Human Thymocytes Express CCR-3 and Are Activated by Eotaxin
Karin Franz-Bacon,
Daniel J. Dairaghi,
Stefen A. Boehme,
Susan K. Sullivan,
Thomas J. Schall,
Paul J. Conlon,
Naomi Taylor, and
Kevin
B. Bacon
From the Departments of Immunology and Molecular Biology, DNAX
Research Institute, Palo Alto, CA; the Department of Immunology,
Neurocrine Biosciences Inc, San Diego, CA; and the Institut de
Genetique Moleculaire, CNRS UMR 5535, Montpellier, France.
Eotaxin has been characterized as a chemokine involved in eosinophil
activation; however, mRNA for this C-C chemokine has been shown to be
constitutively expressed in thymus. Immunohistochemical analysis showed
a punctate distribution pattern, with eotaxin expression localized
mainly in the medulla and in Hassle's corpuscles. Moreover, the
receptor for eotaxin, CCR-3, was detected on thymocytes, with the
highest level of expression being on the CD8 single-positive population. Equilibrium binding analyses on unfractionated thymocytes demonstrated specific 125I-eotaxin binding profiles
comparable with CCR-3 transfectants. Eotaxin induced cell migration and
mobilization of intracellular calcium in all thymocytes except the
immature CD4 /CD8 population. Eotaxin also
induced the secretion of the chemokines interleukin-8, RANTES, and
macrophage inflammatory protein-1 from thymocyte
cultures in vitro. These results suggest that eotaxin-induced thymocyte
activation may have important physiological implications for lymphocyte
mobilization within and from this lymphoid organ.
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