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Blood, Vol. 93 No. 10 (May 15), 1999:
pp. 3487-3493
The T-Cell Activation Markers CD30 and OX40/CD134 Are Expressed in
Nonoverlapping Subsets of Peripheral T-Cell Lymphoma
Dan Jones,
Christopher D.M. Fletcher,
Karen Pulford,
Aliakbar Shahsafaei, and
David M. Dorfman
From the Department of Pathology and the Division of Hematopathology,
Brigham and Women's Hospital, and Harvard Medical School, Boston, MA;
and the Leukemia Research Fund, Immunodiagnostics Unit, University
Department of Cellular Science, John Radcliffe Hospital, Oxford, UK.
The tumor necrosis factor (TNF) receptor family includes several
important markers of activation in T cells. We examined expression patterns of two T-cell-associated members of these receptors, namely
CD30 and OX40/CD134, in 148 cases of T-cell lymphoma to identify
possible objective immunohistochemical criteria for subclassification of these tumors. CD30 expression was characteristic of tumors with an
anaplastic (46/47 cases [98%]) or large-cell (10/21 [48%]) morphology and was seen in only scattered cells in other tumor types.
In contrast, large numbers of OX40/CD134+ tumors cells
were typical of angioimmunoblastic lymphoma (15/16 [94%]),
angiocentric lymphoma (4/4), a subset of large-cell lymphomas (10/21
[48%]), and lymphomas with a prominent histiocytic component (6/7
[86%]). Strong OX40/CD134 and CD30 coexpression was seen in only 4%
of tumors, typically those with an anaplastic/Hodgkin's-like appearance. OX40/CD134 expression was characteristic of tumors composed
of activated CD4+ T cells and was not seen in small-cell
T-cell lymphomas, lymphoblastic lymphomas, or other tumor types,
including B-cell lymphomas or carcinomas. These results suggest that
immunostaining for OX40/CD134 may be helpful in subclassification of
peripheral T-cell lymphomas and that the patterns of TNF receptor
family expression in these tumors may parallel those seen within
nonneoplastic helper T-cell subsets.
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