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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Carlsson, L. E. Articles by Greinacher, A. Search for Related Content PubMed PubMed Citation Articles by Carlsson, L. E. Articles by Greinacher, A. Related Collections Focus on Hematology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 93 No. 11 (June 1), 1999: pp. 3583-3586 The 2 Gene Coding Sequence T807/A873 of the Platelet Collagen Receptor Integrin 21 Might Be a Genetic Risk Factor for the Development of Stroke in Younger Patients Lena E. Carlsson, Sentot Santoso, Carsten Spitzer, Christof Kessler, and Andreas Greinacher From the Departments of Immunology and Transfusion Medicine and of Neurology, Ernst-Moritz-Arndt-University, Greifswald, Germany; and the Department of Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Germany. The polymorphisms C807T and G873A of the platelet integrin 21 (collagen receptor glycoprotein [GP] Ia-IIa) are linked to the expression density of this receptor. The GPIa T807/A873 allele causes a higher receptor expression, enhancing platelet binding to collagen. This might present a genetic predisposition for the development of thromboembolic complications. In this case-control study, the genotypes of the GPIa C807T polymorphism and presence of conventional risk factors (hypertension, diabetes mellitus, and smoking) were compared in stroke patients and patients without cerebrovascular disease (non-CVD patients) 50 years of age (n = 45 and 41, respectively) and in stroke patients and non-CVD patients more than 50 years of age (n = 182 and 129, respectively. In patients 50 years of age, the T807 allele was the only overrepresented variable (P = .023; odds ratio, 3.02; 95% confidence interval, 1.20 to 7.61) and an independent risk factor, whereas the presence of conventional risk factors was similar between stroke patients 50 years of age and non-CVD patients 50 years of age. Large epidemiological studies should prove whether the platelet collagen receptor GPIa-IIa T807 allele is an independent risk factor for the development of stroke in younger patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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