|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 93 No. 11 (June 1), 1999:
pp. 3866-3875
The Susceptibility to X4 and R5 Human Immunodeficiency Virus-1
Strains of Dendritic Cells Derived In Vitro From
CD34+ Hematopoietic Progenitor Cells Is Primarily
Determined by Their Maturation Stage
Bruno Canque,
Youssef Bakri,
Sandrine Camus,
Micael Yagello,
Abdelaziz Benjouad, and
Jean Claude Gluckman
From ESA 7087 Université Paris 6-Centre Nationale de la
Recherche Scientifique, Laboratoire d'Immunologie Cellulaire de
l'Ecole Pratique des Hautes Etudes, hôpital
Pitié-Salpêtrière, Paris, France; and Laboratoire de
Biochimie, Faculté des Sciences, Rabat, Morocco.
Dendritic cells (DC) were sorted on day 8 from cultures of
CD34+ cells with stem cell factor/Flt-3 ligand/
granulocyte-macrophage colony-stimulating factor (GM-CSF)/tumor
necrosis factor- (TNF-)/interleukin-4 (IL-4). Exposing immature
CCR5+CXCR4lo/ DC to CCR5-dependent human
immunodeficiency virus (HIV)-1Ba-L led to productive and
cytopathic infection, whereas only low virus production occurred in
CXCR4-dependent HIV-1LAI-exposed DC. PCR analysis of the
DC 48 hours postinfection showed efficient entry of
HIV-1Ba-L but not of HIV-1LAI. CD40 ligand- or
monocyte-conditioned medium-induced maturation of
HIV-1Ba-L-infected DC reduced virus production by about 1 Log, while cells became CCR5. However,
HIV-1Ba-L-exposed mature DC harbored 15-fold more viral DNA than their immature counterparts, ruling out inhibition of virus
entry. Simultaneously, CXCR4 upregulation by mature DC coincided with
highly efficient entry of HIV-1LAI which, nonetheless,
replicated at the same low level in mature as in immature DC. In line
with these findings, coculture of HIV-1Ba-L-infected
immature DC with CD3 monoclonal antibody-activated autologous
CD4+ T lymphocytes in the presence of AZT decreased virus
production by the DC. Finally, whether they originated from
CD1a+CD14 or
CD1aCD14+ precursors, DC did not differ as
regards permissivity to HIV, although
CD1a+CD14 precursor-derived immature DC
could produce higher HIV-1Ba-L amounts than their
CD1aCD14+ counterparts. Thus, both DC
permissivity to, and capacity to support replication of, HIV is
primarily determined by their maturation stage.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
B. Liu, A. M. Woltman, H. L. A. Janssen, and A. Boonstra
Modulation of dendritic cell function by persistent viruses
J. Leukoc. Biol.,
February 1, 2009;
85(2):
205 - 214.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Trapp, N. R. Derby, R. Singer, A. Shaw, V. G. Williams, S. G. Turville, J. W. Bess Jr., J. D. Lifson, and M. Robbiani
Double-Stranded RNA Analog Poly(I:C) Inhibits Human Immunodeficiency Virus Amplification in Dendritic Cells via Type I Interferon-Mediated Activation of APOBEC3G
J. Virol.,
January 15, 2009;
83(2):
884 - 895.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. van Montfort, A. A. M. Thomas, G. Pollakis, and W. A. Paxton
Dendritic Cells Preferentially Transfer CXCR4-Using Human Immunodeficiency Virus Type 1 Variants to CD4+ T Lymphocytes in trans
J. Virol.,
August 15, 2008;
82(16):
7886 - 7896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gilbert, R. Cantin, C. Barat, and M. J. Tremblay
Human Immunodeficiency Virus Type 1 Replication in Dendritic Cell-T-Cell Cocultures Is Increased upon Incorporation of Host LFA-1 due to Higher Levels of Virus Production in Immature Dendritic Cells
J. Virol.,
July 15, 2007;
81(14):
7672 - 7682.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. U. Cameron, A. J. Handley, D. C. Baylis, A. E. Solomon, N. Bernard, D. F. J. Purcell, and S. R. Lewin
Preferential Infection of Dendritic Cells during Human Immunodeficiency Virus Type 1 Infection of Blood Leukocytes
J. Virol.,
March 1, 2007;
81(5):
2297 - 2306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gilbert, C. Barat, R. Cantin, and M. J. Tremblay
Involvement of Src and Syk Tyrosine Kinases in HIV-1 Transfer from Dendritic Cells to CD4+ T Lymphocytes
J. Immunol.,
March 1, 2007;
178(5):
2862 - 2871.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Donaghy, J. Wilkinson, and A. L. Cunningham
HIV interactions with dendritic cells: has our focus been too narrow?
J. Leukoc. Biol.,
November 1, 2006;
80(5):
1001 - 1012.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Holl, M. Peressin, S. Schmidt, T. Decoville, S. Zolla-Pazner, A.-M. Aubertin, and C. Moog
Efficient inhibition of HIV-1 replication in human immature monocyte-derived dendritic cells by purified anti-HIV-1 IgG without induction of maturation
Blood,
June 1, 2006;
107(11):
4466 - 4474.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Burleigh, P.-Y. Lozach, C. Schiffer, I. Staropoli, V. Pezo, F. Porrot, B. Canque, J.-L. Virelizier, F. Arenzana-Seisdedos, and A. Amara
Infection of Dendritic Cells (DCs), Not DC-SIGN-Mediated Internalization of Human Immunodeficiency Virus, Is Required for Long-Term Transfer of Virus to T Cells
J. Virol.,
March 15, 2006;
80(6):
2949 - 2957.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Cavrois, J. Neidleman, J. F. Kreisberg, D. Fenard, C. Callebaut, and W. C. Greene
Human Immunodeficiency Virus Fusion to Dendritic Cells Declines as Cells Mature
J. Virol.,
February 15, 2006;
80(4):
1992 - 1999.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Wiley and S. Gummuluru
Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection
PNAS,
January 17, 2006;
103(3):
738 - 743.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Williams, D. Mondal, and K. C. Agrawal
The HIV-1 Tat Protein Enhances Megakaryocytic Commitment of K562 Cells by Facilitating CREB Transcription Factor Coactivation by CBP
Experimental Biology and Medicine,
December 1, 2005;
230(11):
872 - 884.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Smed-Sorensen, K. Lore, J. Vasudevan, M. K. Louder, J. Andersson, J. R. Mascola, A.-L. Spetz, and R. A. Koup
Differential Susceptibility to Human Immunodeficiency Virus Type 1 Infection of Myeloid and Plasmacytoid Dendritic Cells
J. Virol.,
July 15, 2005;
79(14):
8861 - 8869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Nobile, C. Petit, A. Moris, K. Skrabal, J.-P. Abastado, F. Mammano, and O. Schwartz
Covert Human Immunodeficiency Virus Replication in Dendritic Cells and in DC-SIGN-Expressing Cells Promotes Long-Term Transmission to Lymphocytes
J. Virol.,
May 1, 2005;
79(9):
5386 - 5399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Popov, A.-L. Chenine, A. Gruber, P.-L. Li, and R. M. Ruprecht
Long-Term Productive Human Immunodeficiency Virus Infection of CD1a-Sorted Myeloid Dendritic Cells
J. Virol.,
January 1, 2005;
79(1):
602 - 608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Balabanian, J. Harriague, C. Decrion, B. Lagane, S. Shorte, F. Baleux, J.-L. Virelizier, F. Arenzana-Seisdedos, and L. A. Chakrabarti
CXCR4-Tropic HIV-1 Envelope Glycoprotein Functions as a Viral Chemokine in Unstimulated Primary CD4+ T Lymphocytes
J. Immunol.,
December 15, 2004;
173(12):
7150 - 7160.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Ganesh, K. Leung, K. Lore, R. Levin, A. Panet, O. Schwartz, R. A. Koup, and G. J. Nabel
Infection of Specific Dendritic Cells by CCR5-Tropic Human Immunodeficiency Virus Type 1 Promotes Cell-Mediated Transmission of Virus Resistant to Broadly Neutralizing Antibodies
J. Virol.,
November 1, 2004;
78(21):
11980 - 11987.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. de Repentigny, D. Lewandowski, and P. Jolicoeur
Immunopathogenesis of Oropharyngeal Candidiasis in Human Immunodeficiency Virus Infection
Clin. Microbiol. Rev.,
October 1, 2004;
17(4):
729 - 759.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Granelli-Piperno, A. Golebiowska, C. Trumpfheller, F. P. Siegal, and R. M. Steinman
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
PNAS,
May 18, 2004;
101(20):
7669 - 7674.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Poudrier, X. Weng, D. G. Kay, Z. Hanna, and P. Jolicoeur
The AIDS-Like Disease of CD4C/Human Immunodeficiency Virus Transgenic Mice Is Associated with Accumulation of Immature CD11bHi Dendritic Cells
J. Virol.,
November 1, 2003;
77(21):
11733 - 11744.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Turville, J. Wilkinson, P. Cameron, J. Dable, and A. L. Cunningham
The role of dendritic cell C-type lectin receptors in HIV pathogenesis
J. Leukoc. Biol.,
November 1, 2003;
74(5):
710 - 718.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. W. Sanders, E. C. de Jong, C. E. Baldwin, J. H. N. Schuitemaker, M. L. Kapsenberg, and B. Berkhout
Differential Transmission of Human Immunodeficiency Virus Type 1 by Distinct Subsets of Effector Dendritic Cells
J. Virol.,
June 27, 2002;
76(15):
7812 - 7821.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-Q. Zhao, X.-L. Huang, P. Gupta, L. Borowski, Z. Fan, S. C. Watkins, E. K. Thomas, and C. R. Rinaldo Jr.
Induction of Anti-Human Immunodeficiency Virus Type 1 (HIV-1) CD8+ and CD4+ T-Cell Reactivity by Dendritic Cells Loaded with HIV-1 X4-Infected Apoptotic Cells
J. Virol.,
February 22, 2002;
76(6):
3007 - 3014.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Fantuzzi, I. Canini, F. Belardelli, and S. Gessani
HIV-1 gp120 Stimulates the Production of {{beta}}-Chemokines in Human Peripheral Blood Monocytes Through a CD4-Independent Mechanism
J. Immunol.,
May 1, 2001;
166(9):
5381 - 5387.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Bakri, C. Schiffer, V. Zennou, P. Charneau, E. Kahn, A. Benjouad, J. C. Gluckman, and B. Canque
The Maturation of Dendritic Cells Results in Postintegration Inhibition of HIV-1 Replication
J. Immunol.,
March 15, 2001;
166(6):
3780 - 3788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ancuta, Y. Bakri, N. Chomont, H. Hocini, D. Gabuzda, and N. Haeffner-Cavaillon
Opposite Effects of IL-10 on the Ability of Dendritic Cells and Macrophages to Replicate Primary CXCR4-Dependent HIV-1 Strains
J. Immunol.,
March 15, 2001;
166(6):
4244 - 4253.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Pohlmann, E. J. Soilleux, F. Baribaud, G. J. Leslie, L. S. Morris, J. Trowsdale, B. Lee, N. Coleman, and R. W. Doms
DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans
PNAS,
February 27, 2001;
98(5):
2670 - 2675.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Neumann, E Afonina, F Ceccherini-Silberstein, S Schlicht, V Erfle, G. Pavlakis, and R Brack-Werner
Nucleocytoplasmic transport in human astrocytes: decreased nuclear uptake of the HIV Rev shuttle protein
J. Cell Sci.,
January 5, 2001;
114(9):
1717 - 1729.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. S. Kornbluth
The emerging role of CD40 ligand in HIV infection
J. Leukoc. Biol.,
September 1, 2000;
68(3):
373 - 382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Mummidi, G. Catano, L. Lam, A. Hoefle, V. Telles, K. Begum, F. Jimenez, S. S. Ahuja, and S. K. Ahuja
Extensive Repertoire of Membrane-bound and Soluble Dendritic Cell-specific ICAM-3-grabbing Nonintegrin 1 (DC-SIGN1) and DC-SIGN2 Isoforms. INTER-INDIVIDUAL VARIATION IN EXPRESSION OF DC-SIGN TRANSCRIPTS
J. Biol. Chem.,
August 24, 2001;
276(35):
33196 - 33212.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
