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Blood, Vol. 93 No. 2 (January 15), 1999:
pp. 613-616
Detailed Deletion Mapping of the Long Arm of Chromosome 6 in
Adult T-Cell Leukemia
Yoshihiro Hatta,
Yasuaki Yamada,
Masao Tomonaga,
Isao Miyoshi,
Jonathan W. Said, and
H. Phillip Koeffler
From the Division of Hematology/Oncology, Cedars-Sinai Research
Institute, UCLA School of Medicine, Los Angeles, CA; the Deparment of
Laboratoy Medicine and the Department of Hematology, Nagasaki
University School of Medicine, Nagasaki, Japan; the Department of
Medicine, Kochi Medical School, Kochi, Japan; and the Department of
Pathology, Center for the Health Science, UCLA School of Medicine, Los
Angeles, CA.
Previously, we have found that the loss of heterozygosity (LOH) was
frequently observed on chromosome 6q in acute/lymphoma-type adult
T-cell leukemia (ATL), suggesting a putative tumor-suppressor gene for
ATL may be present on chromosome 6q. To further define a region
containing this gene, we performed fine-scale deletional mapping of
chromosome 6q in 22 acute/lymphomatous ATL samples using 24 highly
informative microsatellite markers. LOH was found in 9 samples (40.9%)
at 1 or more of the loci examined. Of the 9 samples, 8 shared the same
smallest commonly deleted region flanked by D6S1652 and D6S1644
(6q15-21). The genetic distance between these two loci is approximately
4 cM. These results suggest that a putative tumor-suppressor gene on
chromosome 6q15-21 probably plays a very important role in the
evolution of acute/lymphomatous ATL. Our map provides key information
toward cloning the gene.
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