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Blood, Vol. 93 No. 2 (January 15), 1999:
pp. 624-631
Reduced Expression of Adhesion Molecules and Cell Signaling
Receptors by Chronic Lymphocytic Leukemia Cells With 11q Deletion
Sabine Sembries,
Heike Pahl,
Stephan Stilgenbauer,
Hartmut Döhner, and
Folke Schriever
From the Medizinische Klinik, mit Schwerpunkt Hämatologie und
Onkologie, Charité, Campus Virchow-Klinikum, Humboldt
Universität, Berlin, Germany; Institut für Experimentelle
Anaesthesiologie, Klinikum der Albert-Ludwigs-Universität,
Freiburg, Germany; and Medizinische Klinik und Poliklinik V,
Ruprecht-Karls-Universität, Heidelberg, Germany.
Deletions in chromosome bands 11q22-q23 were recently shown to be
one of the most frequent chromosome aberrations in B-cell chronic
lymphocytic leukemia (B-CLL). Patients suffering from B-CLL with 11q
deletion are characterized by extensive lymphadenopathy, rapid disease
progression, and short survival times. Phenotypic and functional
characteristics of B-CLL cells with 11q deletion that may help to
explain the pathophysiology of this entity are yet unknown. In the
present study, B-CLL cells with (n = 19) and without (n = 19) 11q
deletion were analyzed for their expression of functionally relevant
cell surface molecules (n = 57). B-CLL cells with 11q
deletion carried significantly lower levels of the adhesion molecules
CD11a/CD18 (integrin  L/ 2), CD11c/CD18 (integrin
X/2), CD31 (PECAM-1), CD48, and CD58 (LFA-3).
Furthermore, B-CLL cells with 11q deletion expressed less the cell
signaling receptors CD45 (leukocyte common antigen [LCA]), CD6, CD35
(complement receptor 1), and CD39. Reduced CD45 levels and low-level
expression of CD49d correlated with decreased overall survival. B-CLL
cells with or without 11q deletion did not differ in their growth
fractions, expression levels of transcription factor NF- B, or their
response to mitogenic stimuli. Decreased levels of functionally
relevant adhesion molecules and of cell signaling receptors may
contribute to the pathogenesis of the subgroup of B-CLL characterized
by 11q22-q23 deletion.
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