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Blood, Vol. 93 No. 3 (February 1), 1999:
pp. 826-837
HCA, an Immunoglobulin-Like Adhesion Molecule Present on the
Earliest Human Hematopoietic Precursor Cells, Is Also Expressed by
Stromal Cells in Blood-Forming Tissues
Fernando Cortés,
Frédéric Deschaseaux,
Nobuko Uchida,
Marie-Claude Labastie,
Annabelle M. Friera,
Dongping He,
Pierre Charbord, and
Bruno Péault
From the Institut d'Embryologie Cellulaire et Moléculaire,
CNRS UPR 9064, Nogent-sur-Marne, France; the Établissement de
Transfusion Sanguine, Besançon, France; and SyStemix Inc, Palo
Alto, CA.
We have previously shown that the HCA/ALCAM (CD166) glycoprotein, a
member of the immunoglobulin family that mediates both homophilic and
heterophilic cell-cell adhesion, via the CD6 ligand, is expressed at
the surface of all of the most primitive CD38 /lo,
Thy-1+, rho123lo, CD34+
hematopoietic cells in human fetal liver and fetal and adult bone
marrow. In the present report we show that HCA is also expressed by
subsets of stromal cells in the primary hematopoietic sites that
sequentially develop in the human embryo and fetus, ie, the paraaortic
mesoderm, liver, thymus, and bone marrow. Adult bone marrow stromal
cells established in vitro, including those derived from
Stro-1+ progenitors and cells from immortalized cell
lines, express HCA. In contrast, no HCA expression could be detected in
peripheral lymphoid tissues, fetal spleen, and lymph nodes. HCA
membrane molecules purified from marrow stromal cells interact with
intact marrow stromal cells, CD34+ CD38
hematopoietic precursors, and CD3+ CD6+
peripheral blood lymphocytes. Finally, low but significant levels of
CD6 are here for the first time detected at the surface of CD34+ rho123med/lo progenitors in the bone
marrow and in mobilized blood from healthy individuals. Altogether,
these results indicate that the HCA/ALCAM surface molecule is involved
in homophilic or heterophilic (with CD6) adhesive interactions between
early hematopoietic progenitors and associated stromal cells in primary
blood-forming organs.
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