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Blood, Vol. 93 No. 4 (February 15), 1999:
pp. 1157-1163
Endogenous Interleukin-8 (IL-8) Surge in Granulocyte
Colony-Stimulating Factor-Induced Peripheral Blood Stem Cell
Mobilization
T. Watanabe,
Y. Kawano,
S. Kanamaru,
T. Onishi,
S. Kaneko,
Y. Wakata,
R. Nakagawa,
A. Makimoto,
Y. Kuroda,
Y. Takaue, and
J.E. Talmadge
From the Department of Pediatrics, Tokushima University School of
Medicine, Tokushima, Japan; the Department of Stem Cell
Transplantation, National Cancer Center Hospital, Tokyo, Japan; and the
Department of Pathology/Microbiology, University of Nebraska Medical
Center, Omaha, NE.
The relationship between stem cell mobilization with granulocyte
colony-stimulating factor (G-CSF) and the endogenous production of
interleukin-8 (IL-8), macrophage inflammatory protein-1 (MIP-1), tumor necrosis factor- (TNF-), and interferon- (IFN-) was studied in normal donors for allogeneic peripheral blood stem cell
(PBSC) transplantation. G-CSF was administered to 20 normal donors at a
dose of 10 µg/kg/d for 5 days with aphereses on days 5 and 6 of G-CSF
treatment. Cytokine serum levels were measured using an enzyme-linked
immunosorbent assay (ELISA) before and during G-CSF treatment. Before
treatment, the average level of IL-8 was 7.1 pg/mL, increasing to 207.0 pg/mL on day 5 and 189.1 pg/mL on day 6. Serum IL-8 levels correlated
CD34+ cell numbers (P = .0151 and P = .0005 on days 5 and 6, respectively) and colony-forming
unit-granulocyte-macrophage (CFU-GM) numbers (P = .0019 and
P = .0010 on days 5 and 6, respectively). Furthermore, preapheresis serum IL-8 levels correlated with the yield of
CD34+ cells (P = .0027). In contrast, before
treatment, the average levels of MIP-1, TNF-, and IFN- were
70.1, 4.03, and 3.84 pg/mL, respectively, and no significant changes in
the levels of these cytokines were observed during G-CSF treatment.
These studies suggest that IL-8 production may be critical to
G-CSF-induced stem cell mobilization, although the underlying
mechanism could not be clarified.
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