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Blood, Vol. 93 No. 4 (February 15), 1999:
pp. 1372-1380
Cytogenetic Profile of Lymphoma of Follicle Mantle Lineage:
Correlation With Clinicobiologic Features
Antonio Cuneo,
Renato Bigoni,
Gian Matteo Rigolin,
Maria Grazia Roberti,
Antonella Bardi,
Nadia Piva,
Raffaella Milani,
Florencia Bullrich,
Maria Luisa Veronese,
Carlo Croce,
Françoise Birg,
Hartmut Döhner,
Anne Hagemeijer, and
Gianluigi Castoldi
From the Department of Biomedical Sciences-Hematology Section,
University of Ferrara, Italy; Kimmel Cancer Center, Thomas Jefferson
University, Philadelphia, PA; Ruprecht-Karls-Universitat, Medizinische
Klinik und Poliklinik V, Heidelberg, Germany; Institut de
Cancérologie e d'Immunologie de Marseille, INSERM 119, Marseille, France; and the Centre for Human Genetic, K.U.L., Leuven,
Belgium.
Conventional chromosome analysis (CCA) and interphase fluorescence
in situ hybridization (FISH) was performed in 42 patients with
mantle-cell lymphoma (MCL), with BCL1 rearrangement. The t(11;14)(q13;q32) or 11q abnormalities were detected by CCA in 34 cases, 20 of which had additional aberrations. A normal karyotype was
observed in 8 cases. Probes detecting the chromosome aberrations that
were observed in at least 3 cases by CCA, ie, +12, 13q14 deletion,
and 17p deletion, were used for interphase FISH analysis. FISH detected
total or partial +12, 13q14 deletion and 17p- in 28.5%, 52.4%, and
26% of the cases, respectively. The presence of these anomalies was
not a function of karyotype complexity. Based on the results of
CCA/FISH, three groups of increasing karyotype complexity were
recognized: group 1, including 11 patients without detectable
aberrations in addition to BCL1 rearrangement; group 2, including 14 patients with 1 to 2 additional anomalies; and group 3, including 17 patients with three or more additional anomalies. Clinical
parameters associated with shorter survival were male sex (P
= .006) and primary lymph-node involvement compared with primary bone
marrow involvement (P = .015). Trisomy 12 was the only single cytogenetic parameter predictive of a poor prognosis (P = .006) and the best prognostic indicator was the derived
measure of karyotype complexity (P < .0001), which maintained
statistical significance in multivariate analysis (P< .0001).
We arrived at the following conclusions: 13q14 deletion occurs at a
high incidence in MCL; 17p deletion and total/partial +12 are
relatively frequent events in MCL, the latter aberration being
associated with a shorter survival; and the degree of karyotype
complexity has a strong impact on prognosis in this neoplasia.
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