|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 93 No. 4 (February 15), 1999:
pp. 1413-1421
Oncostatin M Production and Regulation by Human Polymorphonuclear
Neutrophils
Alain Grenier,
Monique Dehoux,
Anne Boutten,
Montserrat Arce-Vicioso,
Geneviève Durand,
Marie-Anne Gougerot-Pocidalo, and
Sylvie Chollet-Martin
From the Laboratoire de Biochimie, Hôpital de Montfermeil,
Montfermeil, France; the Laboratoire de Biochimie, INSERM U 408, Laboratoire d'Hématologie et d'Immunologie et INSERM U 479, Hôpital Bichat, Paris, France; and the Laboratoire de Biochimie,
Faculté de Pharmacie, Chatenay-Malabry, France.
Oncostatin M (OSM) is an interleukin-6 (IL-6) family cytokine known
in particular to induce the synthesis of acute-phase proteins by
hepatocytes. Because human polymorphonuclear neutrophils (PMN) can
secrete numerous cytokines, the potential production of OSM by PMN was
investigated. Highly purified PMN were found to contain an
intracellular stock of preformed OSM that was rapidly mobilized by
degranulating agents such as phorbol myristate acetate and granulocyte-macrophage colony-stimulating factor (GM-CSF). Moreover, PMN produced OSM after a few hours of stimulation by various agonists. The most potent effect was observed with the combination of
lipopolysaccharide and GM-CSF, which had a concentration- and
time-dependent effect at both the protein and mRNA levels. Actinomycin
D strongly reduced OSM mRNA induction, suggesting the involvement of
gene transcription. Cycloheximide inhibited OSM protein synthesis but
did not affect the release of preformed stores. In addition, OSM
production was downregulated by dexamethasone, whereas IL-10 had no
effect. The OSM produced by PMN was biologically active, as
demonstrated by its ability to induce  1-acid glycoprotein synthesis
by HepG2 cells. OSM secretion thus occurs through a two-step mechanism in PMN, consisting of early release of a preformed stock, followed by
de novo protein synthesis. This would allow rapid and sustained OSM
release to occur at inflammatory sites, and may contribute to the
modulation of local inflammation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Hurtado-Nedelec, S. Chollet-Martin, P. Nicaise-Roland, S. Grootenboer-Mignot, R. Ruimy, O. Meyer, and G. Hayem
Characterization of the immune response in the synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome
Rheumatology,
August 1, 2008;
47(8):
1160 - 1167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Hintzen, C. Evers, B. E. Lippok, R. Volkmer, P. C. Heinrich, S. Radtke, and H. M. Hermanns
Box 2 Region of the Oncostatin M Receptor Determines Specificity for Recruitment of Janus Kinases and STAT5 Activation
J. Biol. Chem.,
July 11, 2008;
283(28):
19465 - 19477.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. P. Kastl, W. S. Speidl, C. Kaun, K. M. Katsaros, G. Rega, T. Afonyushkin, V. N. Bochkov, P. Valent, A. Assadian, G. W. Hagmueller, et al.
In Human Macrophages the Complement Component C5a Induces the Expression of Oncostatin M via AP-1 Activation
Arterioscler. Thromb. Vasc. Biol.,
March 1, 2008;
28(3):
498 - 503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Hoarau, B. Gerard, E. Lescanne, D. Henry, S. Francois, J.-J. Lacapere, J. El Benna, P. M.-C. Dang, B. Grandchamp, Y. Lebranchu, et al.
TLR9 Activation Induces Normal Neutrophil Responses in a Child with IRAK-4 Deficiency: Involvement of the Direct PI3K Pathway
J. Immunol.,
October 1, 2007;
179(7):
4754 - 4765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Cohen, S. Marchand-Adam, V. Lecon-Malas, J. Marchal-Somme, A. Boutten, G. Durand, B. Crestani, and M. Dehoux
HGF synthesis in human lung fibroblasts is regulated by oncostatin M
Am J Physiol Lung Cell Mol Physiol,
June 1, 2006;
290(6):
L1097 - L1103.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Stross, S. Radtke, T. Clahsen, C. Gerlach, R. Volkmer-Engert, F. Schaper, P. C. Heinrich, and H. M. Hermanns
Oncostatin M Receptor-mediated Signal Transduction Is Negatively Regulated by SOCS3 through a Receptor Tyrosine-independent Mechanism
J. Biol. Chem.,
March 31, 2006;
281(13):
8458 - 8468.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Queen, R. E. Ryan, R. G. Holzer, C. R. Keller-Peck, and C. L. Jorcyk
Breast Cancer Cells Stimulate Neutrophils to Produce Oncostatin M: Potential Implications for Tumor Progression
Cancer Res.,
October 1, 2005;
65(19):
8896 - 8904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Francois, J. El Benna, P. M. C. Dang, E. Pedruzzi, M.-A. Gougerot-Pocidalo, and C. Elbim
Inhibition of Neutrophil Apoptosis by TLR Agonists in Whole Blood: Involvement of the Phosphoinositide 3-Kinase/Akt and NF-{kappa}B Signaling Pathways, Leading to Increased Levels of Mcl-1, A1, and Phosphorylated Bad
J. Immunol.,
March 15, 2005;
174(6):
3633 - 3642.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Pan, Y. Wang, C. A. Jones, S. T. Glenn, H. Baumann, and K. W. Gross
Enhancer-dependent inhibition of mouse renin transcription by inflammatory cytokines
Am J Physiol Renal Physiol,
January 1, 2005;
288(1):
F117 - F124.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D FRANCHIMONT
Overview of the Actions of Glucocorticoids on the Immune Response: A Good Model to Characterize New Pathways of Immunosuppression for New Treatment Strategies
Ann. N.Y. Acad. Sci.,
June 1, 2004;
1024(1):
124 - 137.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bouchard, C. Ratthe, and D. Girard
Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8
J. Leukoc. Biol.,
May 1, 2004;
75(5):
893 - 900.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Morikawa, S. Tamura, K.-i. Minehata, P. J. Donovan, A. Miyajima, and E. Senba
Essential Function of Oncostatin M in Nociceptive Neurons of Dorsal Root Ganglia
J. Neurosci.,
February 25, 2004;
24(8):
1941 - 1947.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. C. Malcolm and G. S. Worthen
Lipopolysaccharide Stimulates p38-dependent Induction of Antiviral Genes in Neutrophils Independently of Paracrine Factors
J. Biol. Chem.,
April 25, 2003;
278(18):
15693 - 15701.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Hurst, R. M. McLoughlin, J. Monslow, S. Owens, L. Morgan, G. M. Fuller, N. Topley, and S. A. Jones
Secretion of Oncostatin M by Infiltrating Neutrophils: Regulation of IL-6 and Chemokine Expression in Human Mesothelial Cells
J. Immunol.,
November 1, 2002;
169(9):
5244 - 5251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P J Koshy, N Henderson, C Logan, P F Life, T E Cawston, and A D Rowan
Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines
Ann Rheum Dis,
August 1, 2002;
61(8):
704 - 713.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Repovic and E. N. Benveniste
Prostaglandin E2 Is a Novel Inducer of Oncostatin-M Expression in Macrophages and Microglia
J. Neurosci.,
July 1, 2002;
22(13):
5334 - 5343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Grenier, S. Chollet-Martin, B. Crestani, C. Delarche, J. El Benna, A. Boutten, V. Andrieu, G. Durand, M.-A. Gougerot-Pocidalo, M. Aubier, et al.
Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils
Blood,
April 15, 2002;
99(8):
2997 - 3004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Jaffre, M. Dehoux, C. Paugam, A. Grenier, S. Chollet-Martin, J.-B. Stern, J. Mantz, M. Aubier, and B. Crestani
Hepatocyte growth factor is produced by blood and alveolar neutrophils in acute respiratory failure
Am J Physiol Lung Cell Mol Physiol,
February 1, 2002;
282(2):
L310 - L315.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Kerfoot, E. Raharjo, M. Ho, J. Kaur, S. Serirom, D.-M. McCafferty, A. R. Burns, K. D. Patel, and P. Kubes
Exclusive Neutrophil Recruitment with Oncostatin M in a Human System
Am. J. Pathol.,
October 1, 2001;
159(4):
1531 - 1539.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F. Ethuin, C. Delarche, S. Benslama, M.-A. Gougerot-Pocidalo, L. Jacob, and S. Chollet-Martin
Interleukin-12 increases interleukin 8 production and release by human polymorphonuclear neutrophils
J. Leukoc. Biol.,
September 1, 2001;
70(3):
439 - 446.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Lahiri, J. D. Laporte, P. E. Moore, R. A. Panettieri Jr., and S. A. Shore
Interleukin-6 family cytokines: signaling and effects in human airway smooth muscle cells
Am J Physiol Lung Cell Mol Physiol,
June 1, 2001;
280(6):
L1225 - L1232.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. V. B. K. Subrahmanyam, S. Yamaga, Y. Prashar, H. H. Lee, N. P. Hoe, Y. Kluger, M. Gerstein, J. D. Goguen, P. E. Newburger, and S. M. Weissman
RNA expression patterns change dramatically in human neutrophils exposed to bacteria
Blood,
April 15, 2001;
97(8):
2457 - 2468.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. P. Haines, R. B. Voyle, and P. D. Rathjen
Intracellular and Extracellular Leukemia Inhibitory Factor Proteins Have Different Cellular Activities That Are Mediated by Distinct Protein Motifs
Mol. Biol. Cell,
April 1, 2000;
11(4):
1369 - 1383.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. Wang, O. Robledo, E. Kinzie, F. Blanchard, C. Richards, A. Miyajima, and H. Baumann
Receptor Subunit-specific Action of Oncostatin M in Hepatic Cells and Its Modulation by Leukemia Inhibitory Factor
J. Biol. Chem.,
August 11, 2000;
275(33):
25273 - 25285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Baumann, Y. Wang, C. D. Richards, C. A. Jones, T. A. Black, and K. W. Gross
Endotoxin-induced Renal Inflammatory Response. ONCOSTATIN M AS A MAJOR MEDIATOR OF SUPPRESSED RENIN EXPRESSION
J. Biol. Chem.,
July 14, 2000;
275(29):
22014 - 22019.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
