|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 93 No. 5 (March 1), 1999:
pp. 1612-1621
Contribution of Natural Killer Cells to Inhibition of
Angiogenesis by Interleukin-12
Lei Yao,
Cecilia Sgadari,
Keizo Furuke,
Eda T. Bloom,
Julie Teruya-Feldstein, and
Giovanna Tosato
From the Divisions of Hematologic Products and of Cellular and Gene
Therapies, Center for Biologics Evaluation and Research, Food and Drug
Administration; and the Hematopathology Section, Laboratory of
Pathology, National Cancer Institute, Bethesda, MD.
Interleukin-12 (IL-12) inhibits angiogenesis in vivo by inducing
interferon- (IFN-) and other downstream mediators. Here, we
report that neutralization of natural killer (NK) cell function with
antibodies to either asialo GM1 or NK 1.1 reversed IL-12 inhibition of
basic fibroblast growth factor (bFGF)-induced angiogenesis in athymic
mice. By immunohistochemistry, those sites where bFGF-induced neovascularization was inhibited by IL-12 displayed accumulation of NK cells and the presence of IP-10-positive cells. Based on expression of the cytolytic mediators perforin and granzyme B, the NK
cells were locally activated. Experimental Burkitt lymphomas treated
locally with IL-12 displayed tumor tissue necrosis, vascular damage,
and NK-cell infiltration surrounding small vessels. After activation in
vitro with IL-12, NK cells from nude mice became strongly cytotoxic for
primary cultures of syngeneic aortic endothelial cells. Cytotoxicity
was neutralized by antibodies to IFN-. These results document that
NK cells are required mediators of angiogenesis inhibition by IL-12,
and provide evidence that NK-cell cytotoxicity of endothelial cells is
a potential mechanism by which IL-12 can suppress neovascularization.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Del Vecchio, E. Bajetta, S. Canova, M. T. Lotze, A. Wesa, G. Parmiani, and A. Anichini
Interleukin-12: Biological Properties and Clinical Application
Clin. Cancer Res.,
August 15, 2007;
13(16):
4677 - 4685.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Masuda, T. Maruyama, E. Hiratsu, J. Yamane, A. Iwanami, T. Nagashima, M. Ono, H. Miyoshi, H. J. Okano, M. Ito, et al.
Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/{gamma}Formula immunodeficient mice
PNAS,
February 6, 2007;
104(6):
1925 - 1930.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Siddiqui, C.-Y. Li, S. M. LaRue, J. M. Poulson, P. R. Avery, A. F. Pruitt, X. Zhang, R. L. Ullrich, D. E. Thrall, M. W. Dewhirst, et al.
A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas
Mol. Cancer Ther.,
January 1, 2007;
6(1):
380 - 389.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J M Peron, C Bureau, P Gourdy, H Lulka, A Souque, B Calippe, J Selves, T Al Saati, J Bernad, P Cordelier, et al.
Treatment of experimental murine pancreatic peritoneal carcinomatosis with fibroblasts genetically modified to express IL12: a role for peritoneal innate immunity
Gut,
January 1, 2007;
56(1):
107 - 114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. M. Dirkx, M. G. A. oude Egbrink, J. Wagstaff, and A. W. Griffioen
Monocyte/macrophage infiltration in tumors: modulators of angiogenesis
J. Leukoc. Biol.,
December 1, 2006;
80(6):
1183 - 1196.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-c. Chen, R. Wang, X. Zhao, Y.-q. Wei, M. Hu, Y.-s. Wang, X.-w. Zhang, R. Zhang, L. Zhang, B. Yao, et al.
Prophylaxis against carcinogenesis in three kinds of unestablished tumor models via IL12-gene-engineered MSCs
Carcinogenesis,
December 1, 2006;
27(12):
2434 - 2441.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nakayama, N. Mutsuga, L. Yao, and G. Tosato
Prostaglandin E2 promotes degranulation-independent release of MCP-1 from mast cells
J. Leukoc. Biol.,
January 1, 2006;
79(1):
95 - 104.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Davis, K. E. Singer, M. De La Luz Sierra, M. Narazaki, F. Yang, H. M. Fales, R. Yarchoan, and G. Tosato
Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1{alpha} in the circulation
Blood,
June 15, 2005;
105(12):
4561 - 4568.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Nyberg, L. Xie, and R. Kalluri
Endogenous Inhibitors of Angiogenesis
Cancer Res.,
May 15, 2005;
65(10):
3967 - 3979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Harada, M. Shimada, S. Okano, T. Suehiro, Y. Soejima, Y. Tomita, and Y. Maehara
IL-12 Gene Therapy Is an Effective Therapeutic Strategy for Hepatocellular Carcinoma in Immunosuppressed Mice
J. Immunol.,
December 1, 2004;
173(11):
6635 - 6644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Mitra-Kaushik, J. Harding, J. Hess, R. Schreiber, and L. Ratner
Enhanced tumorigenesis in HTLV-1 Tax-transgenic mice deficient in interferon-gamma
Blood,
November 15, 2004;
104(10):
3305 - 3311.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Rakhmilevich, A. T. Hooper, D. J. Hicklin, and P. M. Sondel
Treatment of experimental breast cancer using interleukin-12 gene therapy combined with anti-vascular endothelial growth factor receptor-2 antibody
Mol. Cancer Ther.,
August 1, 2004;
3(8):
969 - 976.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Salvucci, M. Basik, L. Yao, R. Bianchi, and G. Tosato
Evidence for the involvement of SDF-1 and CXCR4 in the disruption of endothelial cell-branching morphogenesis and angiogenesis by TNF-{alpha} and IFN-{gamma}
J. Leukoc. Biol.,
July 1, 2004;
76(1):
217 - 226.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Wong, M.-K. Chan, Z. Yu, R. A. Ghossein, I. Ngai, P. S. Adusumilli, B. M. Stiles, J. P. Shah, B. Singh, and Y. Fong
Angiogenesis Inhibition by an Oncolytic Herpes Virus Expressing Interleukin 12
Clin. Cancer Res.,
July 1, 2004;
10(13):
4509 - 4516.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Murga, L. Yao, and G. Tosato
Derivation of Endothelial Cells from CD34- Umbilical Cord Blood
Stem Cells,
May 1, 2004;
22(3):
385 - 395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. De La Luz Sierra, F. Yang, M. Narazaki, O. Salvucci, D. Davis, R. Yarchoan, H. H. Zhang, H. Fales, and G. Tosato
Differential processing of stromal-derived factor-1{alpha} and stromal-derived factor-1{beta} explains functional diversity
Blood,
April 1, 2004;
103(7):
2452 - 2459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Mitola, M. Strasly, M. Prato, P. Ghia, and F. Bussolino
IL-12 Regulates an Endothelial Cell-Lymphocyte Network: Effect on Metalloproteinase-9 Production
J. Immunol.,
October 1, 2003;
171(7):
3725 - 3733.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-C. Soria, C. Moon, B. L. Kemp, D. D. Liu, L. Feng, X. Tang, Y.-S. Chang, L. Mao, and F. R. Khuri
Lack of Interleukin-10 Expression Could Predict Poor Outcome in Patients with Stage I Non-Small Cell Lung Cancer
Clin. Cancer Res.,
May 1, 2003;
9(5):
1785 - 1791.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Shi, A. L. Rakhmilevich, C. P. Heise, K. Oshikawa, P. M. Sondel, N.-S. Yang, and D. M. Mahvi
Intratumoral Injection of Interleukin-12 Plasmid DNA, Either Naked or in Complex with Cationic Lipid, Results in Similar Tumor Regression in a Murine Model
Mol. Cancer Ther.,
September 1, 2002;
1(11):
949 - 957.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hayakawa, K. Takeda, H. Yagita, M. J. Smyth, L. Van Kaer, K. Okumura, and I. Saiki
IFN-gamma -mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha -galactosylceramide
Blood,
August 13, 2002;
100(5):
1728 - 1733.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Y. Crowe, M. J. Smyth, and D. I. Godfrey
A Critical Role for Natural Killer T Cells in Immunosurveillance of Methylcholanthrene-induced Sarcomas
J. Exp. Med.,
July 1, 2002;
196(1):
119 - 127.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Dredge, J. B. Marriott, S. M. Todryk, G. W. Muller, R. Chen, D. I. Stirling, and A. G. Dalgleish
Protective Antitumor Immunity Induced by a Costimulatory Thalidomide Analog in Conjunction with Whole Tumor Cell Vaccination Is Mediated by Increased Th1-Type Immunity
J. Immunol.,
May 15, 2002;
168(10):
4914 - 4919.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Salvucci, L. Yao, S. Villalba, A. Sajewicz, S. Pittaluga, and G. Tosato
Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1
Blood,
April 15, 2002;
99(8):
2703 - 2711.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Smyth, N. Y. Crowe, D. G. Pellicci, K. Kyparissoudis, J. M. Kelly, K. Takeda, H. Yagita, and D. I. Godfrey
Sequential production of interferon-gamma by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of alpha -galactosylceramide
Blood,
February 15, 2002;
99(4):
1259 - 1266.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Robertson
Role of chemokines in the biology of natural killer cells
J. Leukoc. Biol.,
February 1, 2002;
71(2):
173 - 183.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Soejima and B. J. Rollins
A Functional IFN-{gamma}-Inducible Protein-10/CXCL10-Specific Receptor Expressed by Epithelial and Endothelial Cells That Is Neither CXCR3 Nor Glycosaminoglycan
J. Immunol.,
December 1, 2001;
167(11):
6576 - 6582.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Keane, J. A. Belperio, M. D. Burdick, and R. M. Strieter
IL-12 attenuates bleomycin-induced pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol,
July 1, 2001;
281(1):
L92 - L97.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Pertl, A. D. Luster, N. M. Varki, D. Homann, G. Gaedicke, R. A. Reisfeld, and H. N. Lode
IFN-{{gamma}}-Inducible Protein-10 Is Essential for the Generation of a Protective Tumor-Specific CD8 T Cell Response Induced by Single-Chain IL-12 Gene Therapy
J. Immunol.,
June 1, 2001;
166(11):
6944 - 6951.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gyorffy, K. Palmer, T. J. Podor, M. Hitt, and J. Gauldie
Combined Treatment of a Murine Breast Cancer Model with Type 5 Adenovirus Vectors Expressing Murine Angiostatin and IL-12: A Role for Combined Anti-Angiogenesis and Immunotherapy
J. Immunol.,
May 15, 2001;
166(10):
6212 - 6217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Yao, J. Setsuda, C. Sgadari, B. Cherney, and G. Tosato
Interleukin-18 expression induced by Epstein-Barr virus-infected cells
J. Leukoc. Biol.,
May 1, 2001;
69(5):
779 - 784.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Strasly, F. Cavallo, M. Geuna, S. Mitola, M. P. Colombo, G. Forni, and F. Bussolino
IL-12 Inhibition of Endothelial Cell Functions and Angiogenesis Depends on Lymphocyte-Endothelial Cell Cross-Talk
J. Immunol.,
March 15, 2001;
166(6):
3890 - 3899.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. L. Beatty and Y. Paterson
IFN-{{gamma}}-Dependent Inhibition of Tumor Angiogenesis by Tumor-Infiltrating CD4+ T Cells Requires Tumor Responsiveness to IFN-{{gamma}}
J. Immunol.,
February 15, 2001;
166(4):
2276 - 2282.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. A. Street, E. Cretney, and M. J. Smyth
Perforin and interferon-{gamma} activities independently control tumor initiation, growth, and metastasis
Blood,
January 1, 2001;
97(1):
192 - 197.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Cervenak, L. Morbidelli, D. Donati, S. Donnini, T. Kambayashi, J. L. Wilson, H. Axelson, E. Castanos-Velez, H.-G. Ljunggren, R. D. W. Malefyt, et al.
Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10
Blood,
October 1, 2000;
96(7):
2568 - 2573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. L. Worth, S.-F. Jia, Z. Zhou, L. Chen, and E. S. Kleinerman
Intranasal Therapy with an Adenoviral Vector Containing the Murine Interleukin-12 Gene Eradicates Osteosarcoma Lung Metastases
Clin. Cancer Res.,
September 1, 2000;
6(9):
3713 - 3718.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. J. Smyth, M. Taniguchi, and S. E. A. Street
The Anti-Tumor Activity of IL-12: Mechanisms of Innate Immunity That Are Model and Dose Dependent
J. Immunol.,
September 1, 2000;
165(5):
2665 - 2670.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Yao, S. E. Pike, J. Setsuda, J. Parekh, G. Gupta, M. Raffeld, E. S. Jaffe, and G. Tosato
Effective targeting of tumor vasculature by the angiogenesis inhibitors vasostatin and interleukin-12
Blood,
September 1, 2000;
96(5):
1900 - 1905.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ueno, M. Toi, H. Saji, M. Muta, H. Bando, K. Kuroi, M. Koike, H. Inadera, and K. Matsushima
Significance of Macrophage Chemoattractant Protein-1 in Macrophage Recruitment, Angiogenesis, and Survival in Human Breast Cancer
Clin. Cancer Res.,
August 1, 2000;
6(8):
3282 - 3289.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Q. Huang, J. K. Hu, F. Lohr, L. Zhang, R. Braun, J. Lanzen, J. B. Little, M. W. Dewhirst, and C.-Y. Li
Heat-induced Gene Expression as a Novel Targeted Cancer Gene Therapy Strategy
Cancer Res.,
July 1, 2000;
60(13):
3435 - 3439.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. A. Francisco, K. L. Donaldson, D. Chace, C. B. Siegall, and A. F. Wahl
Agonistic Properties and in Vivo Antitumor Activity of the Anti-CD40 Antibody SGN-14
Cancer Res.,
June 1, 2000;
60(12):
3225 - 3231.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
I. Narvaiza, G. Mazzolini, M. Barajas, M. Duarte, M. Zaratiegui, C. Qian, I. Melero, and J. Prieto
Intratumoral Coinjection of Two Adenoviruses, One Encoding the Chemokine IFN-{gamma}-Inducible Protein-10 and Another Encoding IL-12, Results in Marked Antitumoral Synergy
J. Immunol.,
March 15, 2000;
164(6):
3112 - 3122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Duda, M. Sunamura, L. Lozonschi, T. Kodama, S.-i. Egawa, G. Matsumoto, H. Shimamura, K. Shibuya, K. Takeda, and S. Matsuno
Direct in Vitro Evidence and in Vivo Analysis of the Antiangiogenesis Effects of Interleukin 12
Cancer Res.,
February 1, 2000;
60(4):
1111 - 1116.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. P. Keane, J. A. Belperio, D. A. Arenberg, M. D. Burdick, Z. J. Xu, Y. Y. Xue, and R. M. Strieter
IFN-{gamma}-Inducible Protein-10 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via Inhibition of Angiogenesis
J. Immunol.,
November 15, 1999;
163(10):
5686 - 5692.
[Abstract]
[Full Text]
[ | |
