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Blood, Vol. 93 No. 7 (April 1), 1999:
pp. 2234-2243
Quantification of T-Cell Progenitors During Ontogeny: Thymus
Colonization Depends on Blood Delivery of Progenitors
D. Dunon,
N. Allioli,
O. Vainio,
C. Ody, and
B.A. Imhof
From UMR-CNRS 7622, Université Pierre et Marie Curie, Paris,
France; the Department of Medical Microbiology, Turku University,
Turku, Finland; and the Department of Pathology, Geneva University,
Geneva, Switzerland.
An in vivo thymus reconstitution assay based on intrathymic
injection of hematopoietic progenitors into irradiated chicks was used
to determine the number of T-cell progenitors in peripheral blood,
paraaortic foci, bone marrow (BM), and spleen during ontogeny. This
study allowed us to analyze the regulation of thymus colonization occurring in three waves during embryogenesis. It confirmed that progenitors of the first wave of thymus colonization originate from the
paraaortic foci, whereas progenitors of the second and the third waves
originate from the BM. The analysis of the number of T-cell progenitors
indicates that each wave of thymus colonization is correlated with a
peak number of T-cell progenitors in peripheral blood, whereas they are
almost absent during the periods defined as refractory for
colonization. Moreover, injection of T-cell progenitors into the blood
circulation showed that they homed into the thymus without delay during
the refractory periods. Thus, thymus colonization kinetics depend
mainly on the blood delivery of T-cell progenitors during embryogenesis.
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