SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hasegawa, S. Articles by Ra, C. Search for Related Content PubMed PubMed Citation Articles by Hasegawa, S. Articles by Ra, C. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, Vol. 93 No. 8 (April 15), 1999: pp. 2543-2551 Functional Expression of the High Affinity Receptor for IgE (FcRI) in Human Platelets and Its' Intracellular Expression in Human Megakaryocytes Shunji Hasegawa, Ruby Pawankar, Katsuhiro Suzuki, Tatsutoshi Nakahata, Susumu Furukawa, Ko Okumura, and Chisei Ra From the Department of Immunology, Juntendo University, School of Medicine, Tokyo, Japan; Department of Pediatrics, Yamaguchi University, School of Medicine, Yamaguchi, Japan; and the Department of Clinical Oncology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. The high affinity IgE receptor (FcRI) expressed on the cell surface of mast cells and basophils is the key molecule in triggering the IgE-mediated allergic reaction. Recently, it was elucidated that the FcRI is expressed on a variety of other cells like Langerhans cells, monocytes, and eosinophils, and the functional importance of the FcRI expression in Langerhans cells was also shown. Some studies suggest that human platelets may play important roles in allergic inflammation through the cell-surface expression of the FcRII and FcRII. Here, we report that human platelets and megakaryocytes constitutively express the messenger RNA and protein for the FcRI. Although the FcRI is expressed on the cell surface of human platelets, it is only detected in the cytoplasm of human megakaryocytes. We also confirmed that human platelets express the genes for the , , and  chains of the FcRI without any defined mutations. Furthermore, stimulation of human platelets via the FcRI induced the release of serotonin and RANTES (Regulated on Activation, Normal T Expressed, and presumably Secreted). Taken together, these results suggest a novel and important role for human platelets in perpetuating allergic inflammation through the expression of and activation via the FcRI. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. C. Pitchford, S. Momi, S. Baglioni, L. Casali, S. Giannini, R. Rossi, C. P. Page, and P. Gresele Allergen Induces the Migration of Platelets to Lung Tissue in Allergic Asthma Am. J. Respir. Crit. Care Med., March 15, 2008; 177(6): 604 - 612. [Abstract] [Full Text] [PDF] R. Tamagawa-Mineoka, N. Katoh, E. Ueda, H. Takenaka, M. Kita, and S. Kishimoto The Role of Platelets in Leukocyte Recruitment in Chronic Contact Hypersensitivity Induced by Repeated Elicitation Am. J. Pathol., June 1, 2007; 170(6): 2019 - 2029. [Abstract] [Full Text] [PDF] K. Takahashi, N. Hayashi, S. Kaminogawa, and C. Ra Molecular Mechanisms for Transcriptional Regulation of Human High-Affinity IgE Receptor beta-Chain Gene Induced by GM-CSF J. Immunol., October 1, 2006; 177(7): 4605 - 4611. [Abstract] [Full Text] [PDF] D. M. Cauvi, X. Tian, K. von Loehneysen, and M. W. Robertson Transport of the IgE Receptor {alpha}-Chain Is Controlled by a Multicomponent Intracellular Retention Signal J. Biol. Chem., April 14, 2006; 281(15): 10448 - 10460. [Abstract] [Full Text] [PDF] M. Suzukawa, K. Hirai, M. Iikura, H. Nagase, A. Komiya, C. Yoshimura-Uchiyama, H. Yamada, C. Ra, K. Ohta, K. Yamamoto, et al. IgE- and Fc{varepsilon}RI-mediated migration of human basophils Int. Immunol., September 1, 2005; 17(9): 1249 - 1255. [Abstract] [Full Text] [PDF] L. A. Weiss, L. A. Lester, J. E. Gern, R. L. Wolf, R. Parry, R. F. Lemanske, J. Solway, and C. Ober Variation in ITGB3 Is Associated with Asthma and Sensitization to Mold Allergen in Four Populations Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 67 - 73. [Abstract] [Full Text] [PDF] E. Yokoo, Y. Yatomi, T. Takafuta, M. Osada, Y. Okamoto, and Y. Ozaki Sphingosine 1-Phosphate Inhibits Migration of RBL-2H3 Cells via S1P2: Cross-Talk between Platelets and Mast Cells J. Biochem., June 1, 2004; 135(6): 673 - 681. [Abstract] [Full Text] [PDF] J. P. McRedmond, S. D. Park, D. F. Reilly, J. A. Coppinger, P. B. Maguire, D. C. Shields, and D. J. Fitzgerald Integration of Proteomics and Genomics in Platelets: A PROFILE OF PLATELET PROTEINS AND PLATELET-SPECIFIC GENES Mol. Cell. Proteomics, February 1, 2004; 3(2): 133 - 144. [Abstract] [Full Text] [PDF] K. Takahashi, C. Nishiyama, M. Hasegawa, Y. Akizawa, and C. Ra Regulation of the Human High Affinity IgE Receptor {beta}-Chain Gene Expression Via an Intronic Element J. Immunol., September 1, 2003; 171(5): 2478 - 2484. [Abstract] [Full Text] [PDF] M. Hasegawa, C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Mitsuishi, T. Ito, H. Kawada, S. Furukawa, C. Ra, K. Okumura, et al. A Novel -66T/C Polymorphism in Fc{epsilon}RI {alpha}-Chain Promoter Affecting the Transcription Activity: Possible Relationship to Allergic Diseases J. Immunol., August 15, 2003; 171(4): 1927 - 1933. [Abstract] [Full Text] [PDF] M. Hasegawa, C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Takahashi, T. Ito, S. Furukawa, C. Ra, K. Okumura, and H. Ogawa Regulation of the Human Fc{epsilon}RI {alpha}-Chain Distal Promoter J. Immunol., April 1, 2003; 170(7): 3732 - 3738. [Abstract] [Full Text] [PDF] H. Kayaba, D. Dombrowicz, G. Woerly, J.-P. Papin, S. Loiseau, and M. Capron Human Eosinophils and Human High Affinity IgE Receptor Transgenic Mouse Eosinophils Express Low Levels of High Affinity IgE Receptor, but Release IL-10 upon Receptor Activation J. Immunol., July 15, 2001; 167(2): 995 - 1003. [Abstract] [Full Text] [PDF] A. S. GOUNNI, B. LAMKHIOUED, L. KOUSSIH, C. RA, P. M. RENZI, and Q. HAMID Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc{varepsilon}RI): role in asthma FASEB J, April 1, 2001; 15(6): 940 - 949. [Abstract] [Full Text] [PDF] M. Mitsuhashi, A. Tanaka, C. Fujisawa, K. Kawamoto, A. Itakura, M. Takaku, T. Hironaka, S. Sawada, and H. Matsuda Necessity of Thromboxane A2 for Initiation of Platelet-Mediated Contact Sensitivity: Dual Activation of Platelets and Vascular Endothelial Cells J. Immunol., January 1, 2001; 166(1): 617 - 623. [Abstract] [Full Text] [PDF] B. Albrecht, M. Woisetschlager, and M. W. Robertson Export of the High Affinity IgE Receptor From the Endoplasmic Reticulum Depends on a Glycosylation-Mediated Quality Control Mechanism J. Immunol., November 15, 2000; 165(10): 5686 - 5694. [Abstract] [Full Text] [PDF]

	Copyright © 1999 by American Society of Hematology         Online ISSN: 1528-0020