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Blood, Vol. 94 No. 1 (July 1), 1999:
pp. 362-364
t(1;2)(q21;p23) and t(2;3)(p23;q21): Two Novel Variant Translocations
of the t(2;5)(p23;q35) in Anaplastic Large Cell Lymphoma
Andreas Rosenwald,
German Ott,
Karen Pulford,
Tiemo Katzenberger,
Joachim Kühl,
Jörg Kalla,
M. Michaela Ott,
David Y. Mason, and
Hans Konrad Müller-Hermelink
From the Pathologisches Institut and Kinderklinik, University of
Würzburg, Würzburg, Germany; and the University Department
of Cellular Science, John Radcliffe Hospital, Oxford, UK.
Cytogenetic investigations in two cases of anaplastic large cell
lymphoma (ALCL) showed novel variants of the classical (2;5)(p23;q35) translocation, namely a t(1;2)(q21;p23) and a t(2;3)(p23;q21). The
tumor cells in both cases gave positive immunohistochemical labeling
for ALK protein (with both monoclonal and polyclonal antibodies),
demonstrating that these translocations induce aberrant expression of
this kinase and suggesting that genes other than NPM can
activate the ALK gene in ALCL. These two cases were shown by an
in vitro kinase assay to express ALK kinases (104 kD and 97 kD,
respectively), which differed in size from the classical NPM-ALK fusion
product (80 kD). Moreover, ALK expression was confined to the cytoplasm
of the tumor cells in each case, supporting the hypothesis that the
observed nuclear localization of NPM-ALK in classical ALCL is not the
site of oncogenic activity of the ALK kinase.
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