|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 94 No. 1 (July 1), 1999:
pp. 46-51
Prothrombotic Genetic Risk Factors in Young Survivors of Myocardial
Infarction
D. Ardissino,
P.M. Mannucci,
P.A. Merlini,
F. Duca,
R. Fetiveau,
L. Tagliabue,
M. Tubaro,
M. Galvani,
F. Ottani,
M. Ferrario,
J. Corral, and
M. Margaglione
From the Division of Cardiology, IRCCS Policlinico San Matteo and
University of Pavia, Pavia; the Angelo Bianchi Bonomi Hemophilia and
Thrombosis Centre and the Department of Internal Medicine, IRCCS
Maggiore Hospital, University of Milan, Milan, Italy; Niguarda Hospital
Ca' Granda, Milan; San Camillo Hospital, Rome; Gian Battista Morgagni
Hospital, Forli'; Bentivoglio Hospital, Bentivoglio; Regional
Transfusion Centre, Murcia, Spain; and IRCCS Casa Sollievo della
Sofferenza, S. Giovanni Rotondo, Italy.
It has long been thought that an individual thrombotic tendency
increases the risk of myocardial infarction, especially in young
adults. Several "prothrombotic" genetic factors that may influence the individual thrombotic risk have been identified. To
investigate the association between the risk of myocardial infarction
at a young age and genetic factors thought to be associated with an
increased tendency to thrombosis (the polymorphisms 4G/5G of the PAI-1
gene, PIA1/PIA2 of the platelet glycoprotein IIIa, C3550T of the
platelet glycoprotein Ib gene, G10976A of the factor VII gene, C677T of
the methylenetetrahydrofolate reductase gene, G1691A of the factor V
gene, and G20210A of the prothrombin gene), we performed a case-control
study evaluating 200 survivors (185 men, 15 women) of myocardial
infarction who had experienced the event before the age of 45 years and
200 healthy subjects with a negative exercise test, individually
matched for sex, age, and geographic origin with the cases. The
presence of the PIA2 polymorphic allele was the only prothrombotic
genetic factor associated with the risk of myocardial infarction at a
young age. The odds ratio for carriers of the PIA2 allele compared with
those of the PIA1 allele was 1.84 (95% confidence intervals (CI) 1.12 to 3.03). There was a significant interaction between the presence of
the PIA2 allele and smoking: with their simultaneous presence, 46% (95% confidence intervals 11% to 81%) of premature myocardial infarctions were attributable to the interaction between the two factors. In conclusion, carrying the PIA2 polymorphic allele of platelet glycoprotein IIIa was the only genetic prothrombotic factor
associated with the risk of developing myocardial infarction at a young
age. The clinical expression of this genetic predisposition seems to be
enhanced by smoking.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. P. Corsetti, D. Ryan, A. J. Moss, D. L. Rainwater, W. Zareba, and C. E. Sparks
Glycoprotein Ib{alpha} Polymorphism T145M, Elevated Lipoprotein-Associated Phospholipase A2, and Hypertriglyceridemia Predict Risk for Recurrent Coronary Events in Diabetic Postinfarction Patients
Diabetes,
May 1, 2007;
56(5):
1429 - 1435.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Feinbloom and K. A. Bauer
Assessment of Hemostatic Risk Factors in Predicting Arterial Thrombotic Events
Arterioscler. Thromb. Vasc. Biol.,
October 1, 2005;
25(10):
2043 - 2053.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. K. MacCallum
Markers of Hemostasis and Systemic Inflammation in Heart Disease and Atherosclerosis in Smokers
Proceedings of the ATS,
April 1, 2005;
2(1):
34 - 43.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Mikkelsson, M. Perola, and P. J. Karhunen
Genetics of Platelet Glycoprotein Receptors: Risk of Thrombotic Events and Pharmacogenetic Implications
Clinical and Applied Thrombosis/Hemostasis,
April 1, 2005;
11(2):
113 - 125.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. J. Glueck, N. Goldenberg, P. Wang, and D. Aregawi
Ramifications of Four Concurrent Thrombophilic Mutations and One Hypofibrinolytic Mutation
Clinical and Applied Thrombosis/Hemostasis,
October 1, 2004;
10(4):
365 - 371.
[Abstract]
[PDF]
|
|
|
|
|
|
|
I. Bank, E. J. Libourel, S. Middeldorp, E. C. M. van Pampus, M. M. W. Koopman, K. Hamulyak, M. H. Prins, J. van der Meer, and H. R. Buller
Prothrombin 20210A Mutation: A Mild Risk Factor for Venous Thromboembolism but Not for Arterial Thrombotic Disease and Pregnancy-Related Complications in a Family Study
Arch Intern Med,
September 27, 2004;
164(17):
1932 - 1937.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Vanschoonbeek, M. A.H. Feijge, M. Paquay, J. Rosing, W. Saris, C. Kluft, P. L.A. Giesen, M. P.M. de Maat, and J. W.M. Heemskerk
Variable Hypocoagulant Effect of Fish Oil Intake in Humans: Modulation of Fibrinogen Level and Thrombin Generation
Arterioscler. Thromb. Vasc. Biol.,
September 1, 2004;
24(9):
1734 - 1740.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Voetsch and J. Loscalzo
Genetic Determinants of Arterial Thrombosis
Arterioscler. Thromb. Vasc. Biol.,
February 1, 2004;
24(2):
216 - 229.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F Burzotta, K Paciaroni, V De Stefano, F Crea, A Maseri, G Leone, and F Andreotti
G20210A Prothrombin gene polymorphism and coronary ischaemic syndromes: a phenotype-specific meta-analysis of 12 034 subjects
Heart,
January 1, 2004;
90(1):
82 - 86.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Bojesen, K. Juul, P. Schnohr, A. Tybjaerg-Hansen, and B.o. G. Nordestgaard
Platelet glycoprotein IIb/IIIa PlA2/PlA2 homozygosity associated with risk of ischemic cardiovascular disease and myocardial infarction in young men: The Copenhagen City Heart Study
J. Am. Coll. Cardiol.,
August 20, 2003;
42(4):
661 - 667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Atherosclerosis, Thrombosis, and Vascular Biology
No Evidence of Association Between Prothrombotic Gene Polymorphisms and the Development of Acute Myocardial Infarction at a Young Age
Circulation,
March 4, 2003;
107(8):
1117 - 1122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Klerk, P. Verhoef, R. Clarke, H. J. Blom, F. J. Kok, E. G. Schouten, and and the MTHFR Studies Collaboration Group
MTHFR 677C->T Polymorphism and Risk of Coronary Heart Disease: A Meta-analysis
JAMA,
October 23, 2002;
288(16):
2023 - 2031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Juul, A. Tybjarg-Hansen, R. Steffensen, S. Kofoed, G. Jensen, and B. G. Nordestgaard
Factor V Leiden: The Copenhagen City Heart Study and 2 meta-analyses
Blood,
June 17, 2002;
100(1):
3 - 10.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. B. Braunstein, D. W. Kershner, P. Bray, G. Gerstenblith, S. P. Schulman, W. S. Post, and R. S. Blumenthal
Interaction of Hemostatic Genetics With Hormone Therapy : New Insights To Explain Arterial Thrombosis in Postmenopausal Women
Chest,
March 1, 2002;
121(3):
906 - 920.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Benze, J. Heinrich, H. Schulte, S. Rust, U. Nowak-Gottl, M.-C. Tataru, E. Kohler, G. Assmann, and R. Junker
Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in men
Eur. Heart J.,
February 2, 2002;
23(4):
325 - 330.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Burzotta, K. Paciaroni, V. De Stefano, P. Chiusolo, A. Manzoli, I. Casorelli, A.M. Leone, E. Rossi, G. Leone, A. Maseri, et al.
Increased prevalence of the G20210A prothrombin gene variant in acute coronary syndromes without metabolic or acquired risk factors or with limited extent of disease
Eur. Heart J.,
January 1, 2002;
23(1):
26 - 30.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Kunicki
The Influence of Platelet Collagen Receptor Polymorphisms in Hemostasis and Thrombotic Disease
Arterioscler. Thromb. Vasc. Biol.,
January 1, 2002;
22(1):
14 - 20.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Douglas, K Michaelides, D A Gorog, E Durante-Mangoni, N Ahmed, G J Davies, and E G D Tuddenham
Platelet membrane glycoprotein Ib{alpha} gene -5T/C Kozak sequence polymorphism as an independent risk factor for the occurrence of coronary thrombosis
Heart,
January 1, 2002;
87(1):
70 - 74.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Boekholdt, N. R. Bijsterveld, A. H.M. Moons, M. Levi, H. R. Buller, and R. J.G. Peters
Genetic Variation in Coagulation and Fibrinolytic Proteins and Their Relation With Acute Myocardial Infarction: A Systematic Review
Circulation,
December 18, 2001;
104(25):
3063 - 3068.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. F. O'Connor, D. C. Shields, A. Fitzgerald, C. P. Cannon, E. Braunwald, and D. J. Fitzgerald
Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes
Blood,
December 1, 2001;
98(12):
3256 - 3260.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Barakat, S. Kennon, G. A. Hitman, E. Aganna, C. P. Price, P. G. Mills, K. Ranjadayalan, B. North, H. Clarke, and A. D. Timmis
Interaction between smoking and the glycoprotein IIIa P1A2 polymorphism in Non-ST-elevation acute coronary syndromes
J. Am. Coll. Cardiol.,
November 15, 2001;
38(6):
1639 - 1643.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Mikkelsson, M. Perola, A. Penttila, and P. J. Karhunen
Platelet Glycoprotein Ib{alpha} HPA-2 Met/VNTR B Haplotype as a Genetic Predictor of Myocardial Infarction and Sudden Cardiac Death
Circulation,
August 21, 2001;
104(8):
876 - 880.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Russo, D. Girelli, O. Olivieri, P. Guarini, F. Manzato, F. Pizzolo, B. Zaia, A. Mazzucco, and R. Corrocher
G20210A Prothrombin Gene Polymorphism and Prothrombin Activity in Subjects With or Without Angiographically Documented Coronary Artery Disease
Circulation,
May 22, 2001;
103(20):
2436 - 2440.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Williams and P. F. Bray
Genetics of Arterial Prothrombotic Risk States
Experimental Biology and Medicine,
May 1, 2001;
226(5):
409 - 419.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. M. Mannucci, D. Girelli, F. Bernardi, and R. Corrocher
Polymorphisms in the Factor VII Gene and the Risk of Myocardial Infarction
N. Engl. J. Med.,
February 8, 2001;
344(6):
458 - 459.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Endler, P. A. Kyrle, S. Eichinger, M. Exner, and C. Mannhalter
Multiplexed Mutagenically Separated PCR: Simultaneous Single-Tube Detection of the Factor V R506Q (G1691A), the Prothrombin G20210A, and the Methylenetetrahydrofolate Reductase A223V (C677T) Variants
Clin. Chem.,
February 1, 2001;
47(2):
333 - 335.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T C F Sykes, C Fegan, and D Mosquera
Thrombophilia, polymorphisms, and vascular disease
Mol. Pathol.,
December 1, 2000;
53(6):
300 - 306.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. Mikkelsson, M. Perola, P. Laippala, A. Penttila, and P. J. Karhunen
Glycoprotein IIIa PlA1/A2 polymorphism and sudden cardiac death
J. Am. Coll. Cardiol.,
October 1, 2000;
36(4):
1317 - 1323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Girelli, C. Russo, P. Ferraresi, O. Olivieri, M. Pinotti, S. Friso, F. Manzato, A. Mazzucco, F. Bernardi, and R. Corrocher
Polymorphisms in the Factor VII Gene and the Risk of Myocardial Infarction in Patients with Coronary Artery Disease
N. Engl. J. Med.,
September 14, 2000;
343(11):
774 - 780.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Lane and P. J. Grant
Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease
Blood,
March 1, 2000;
95(5):
1517 - 1532.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Batalla, J. R. Reguero, G. I. Cubero, and E. Coto
Prothrombotic Genetic Risk Factors and Myocardial Infarction at Young Age
Blood,
December 1, 1999;
94(11):
3959 - 3960.
[Full Text]
[PDF]
|
|
|
|
|
