|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 94 No. 11 (December 1), 1999:
pp. 3737-3747
A Novel BTB/POZ Transcriptional Repressor Protein Interacts With the
Fanconi Anemia Group C Protein and PLZF
Maureen E. Hoatlin,
Yu Zhi,
Helen Ball,
Kirsten Silvey,
Ari Melnick,
Stacie Stone,
Sally Arai,
Nicola Hawe,
Gareth Owen,
Arthur Zelent, and
Jonathan D. Licht
From Division of Hematology and Medical Oncology, Oregon Health
Sciences University, Portland, OR; Derald H. Ruttenberg
Cancer Center and Department of Medicine, Mount Sinai School of
Medicine, New York, NY; and The Leukemia Research Fund Center,
Institute of Cancer Research, London, UK.
Fanconi anemia (FA) is an autosomal recessive cancer
susceptibility syndrome. The phenotype includes developmental defects, bone marrow failure, and cell cycle abnormalities. At least eight complementation groups (A-H) exist, and although three of the corresponding complementation group genes have been cloned, they lack
recognizable motifs, and their functions are unknown. We have isolated
a binding partner for the Fanconi anemia group C protein (FANCC) by
yeast two-hybrid screening. We show that the novel gene, FAZF, encodes
a 486 amino acid protein containing a conserved amino terminal BTB/POZ
protein interaction domain and three C-terminal Krüppel-like zinc
fingers. FAZF is homologous to the promyelocytic leukemia zinc finger
(PLZF) protein, which has been shown to act as a transcriptional
repressor by recruitment of nuclear corepressors (N-CoR, Sin3, and
HDAC1 complex). Consistent with a role in FA, BTB/POZ-containing
proteins have been implicated in oncogenesis, limb morphogenesis,
hematopoiesis, and proliferation. We show that FAZF is a
transcriptional repressor that is able to bind to the same DNA target
sequences as PLZF. Our data suggest that the FAZF/FANCC interaction
maps to a region of FANCC deleted in FA patients with a severe disease
phenotype. We also show that FAZF and wild-type FANCC can colocalize in
nuclear foci, whereas a patient-derived mutant FANCC that is
compromised for nuclear localization cannot. These results suggest that
the function of FANCC may be linked to a transcriptional repression
pathway involved in chromatin remodeling.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. Mohseni-Meybodi, H. Mozdarani, and S. Mozdarani
DNA damage and repair of leukocytes from Fanconi anaemia patients, carriers and healthy individuals as measured by the alkaline comet assay
Mutagenesis,
January 1, 2009;
24(1):
67 - 73.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Costoya
Functional analysis of the role of POK transcriptional repressors
Brief Funct Genomic Proteomic,
March 24, 2007;
(2007)
elm002v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Weber, Y. Xu, L. Zhang, A. Patocs, L. Shen, P. Platzer, and C. Eng
Microenvironmental Genomic Alterations and Clinicopathological Behavior in Head and Neck Squamous Cell Carcinoma
JAMA,
January 10, 2007;
297(2):
187 - 195.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Zhao, S. Maruo, A. Cooper, M. R. Chase, E. Johannsen, E. Kieff, and E. Cahir-McFarland
RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines
PNAS,
February 7, 2006;
103(6):
1900 - 1905.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Maeda, R. M. Hobbs, and P. P. Pandolfi
The Transcription Factor Pokemon: A New Key Player in Cancer Pathogenesis
Cancer Res.,
October 1, 2005;
65(19):
8575 - 8578.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Piazza, J. A. Costoya, T. Merghoub, R. M. Hobbs, and P. P. Pandolfi
Disruption of PLZP in Mice Leads to Increased T-Lymphocyte Proliferation, Cytokine Production, and Altered Hematopoietic Stem Cell Homeostasis
Mol. Cell. Biol.,
December 1, 2004;
24(23):
10456 - 10469.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R. Fagerlie, T. Koretsky, B. Torok-Storb, and G. C. Bagby
Impaired Type I IFN-Induced Jak/STAT Signaling in FA-C Cells and Abnormal CD4+ Th Cell Subsets in Fancc-/- Mice
J. Immunol.,
September 15, 2004;
173(6):
3863 - 3870.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Thomashevski, A. A. High, M. Drozd, J. Shabanowitz, D. F. Hunt, P. A. Grant, and G. M. Kupfer
The Fanconi Anemia Core Complex Forms Four Complexes of Different Sizes in Different Subcellular Compartments
J. Biol. Chem.,
June 18, 2004;
279(25):
26201 - 26209.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Brodeur, I. Goulet, C. S. Tremblay, C. Charbonneau, M.-C. Delisle, C. Godin, C. Huard, E. W. Khandjian, M. Buchwald, G. Levesque, et al.
Regulation of the Fanconi Anemia Group C Protein through Proteolytic Modification
J. Biol. Chem.,
February 6, 2004;
279(6):
4713 - 4720.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-C. Miaw, B. Y. Kang, I. A. White, and I-C. Ho
A Repressor of GATA-Mediated Negative Feedback Mechanism of T Cell Activation
J. Immunol.,
January 1, 2004;
172(1):
170 - 177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Yamamoto, M. Ishiai, N. Matsushita, H. Arakawa, J. E. Lamerdin, J.-M. Buerstedde, M. Tanimoto, M. Harada, L. H. Thompson, and M. Takata
Fanconi Anemia FANCG Protein in Mitigating Radiation- and Enzyme-Induced DNA Double-Strand Breaks by Homologous Recombination in Vertebrate Cells
Mol. Cell. Biol.,
August 1, 2003;
23(15):
5421 - 5430.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. W. Lensch, M. Tischkowitz, T. A. Christianson, C. A. Reifsteck, S. A. Speckhart, P. M. Jakobs, M. E. O'Dwyer, S. B. Olson, M. M. Le Beau, S. V. Hodgson, et al.
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia
Blood,
July 1, 2003;
102(1):
7 - 16.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hadjur and F. R. Jirik
Increased sensitivity of Fancc-deficient hematopoietic cells to nitric oxide and evidence that this species mediates growth inhibition by cytokines
Blood,
May 15, 2003;
101(10):
3877 - 3884.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M D Tischkowitz and S V Hodgson
Fanconi anaemia
J. Med. Genet.,
January 1, 2003;
40(1):
1 - 10.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Bogliolo, O. Cabre, E. Callen, V. Castillo, A. Creus, R. Marcos, and J. Surralles
The Fanconi anaemia genome stability and tumour suppressor network
Mutagenesis,
November 1, 2002;
17(6):
529 - 538.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Folias, M. Matkovic, D. Bruun, S. Reid, J. Hejna, M. Grompe, A. D'Andrea, and R. Moses
BRCA1 interacts directly with the Fanconi anemia protein FANCA
Hum. Mol. Genet.,
October 2, 2002;
11(21):
2591 - 2597.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Callen, M.J. Ramirez, A. Creus, R. Marcos, S. Frias, B. Molina, I. Badell, T. Olive, J.J. Ortega, and J. Surralles
The clastogenic response of the 1q12 heterochromatic region to DNA cross-linking agents is independent of the Fanconi anaemia pathway
Carcinogenesis,
August 1, 2002;
23(8):
1267 - 1271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-S. Dai, N. Chevallier, S. Stone, M. C. Heinrich, M. McConnell, T. Reuter, H. E. Broxmeyer, J. D. Licht, L. Lu, and M. E. Hoatlin
The Effects of the Fanconi Anemia Zinc Finger (FAZF) on Cell Cycle, Apoptosis, and Proliferation Are Differentiation Stage-specific
J. Biol. Chem.,
July 12, 2002;
277(29):
26327 - 26334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tsuzuki and T. Enver
Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein
Blood,
May 1, 2002;
99(9):
3404 - 3410.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Melnick, G. Carlile, K. F. Ahmad, C.-L. Kiang, C. Corcoran, V. Bardwell, G. G. Prive, and J. D. Licht
Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors
Mol. Cell. Biol.,
March 15, 2002;
22(6):
1804 - 1818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Kim, X. Fang, H. Ji, A. F. Paulson, J. M. Daniel, M. Ciesiolka, F. van Roy, and P. D. McCrea
Isolation and Characterization of XKaiso, a Transcriptional Repressor That Associates with the Catenin Xp120ctn in Xenopus laevis
J. Biol. Chem.,
March 1, 2002;
277(10):
8202 - 8208.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yang, Y. Kuang, R. M. De Oca, T. Hays, L. Moreau, N. Lu, B. Seed, and A. D. D'Andrea
Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9
Blood,
December 1, 2001;
98(12):
3435 - 3440.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Otsuki, Y. Furukawa, K. Ikeda, H. Endo, T. Yamashita, A. Shinohara, A. Iwamatsu, K. Ozawa, and J. M. Liu
Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex
Hum. Mol. Genet.,
November 1, 2001;
10(23):
2651 - 2660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Grompe and A. D'Andrea
Fanconi anemia and DNA repair
Hum. Mol. Genet.,
October 1, 2001;
10(20):
2253 - 2259.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Collins, J. R. Stone, and A. J. Williams
All in the Family: the BTB/POZ, KRAB, and SCAN Domains
Mol. Cell. Biol.,
June 1, 2001;
21(11):
3609 - 3615.
[Full Text]
|
|
|
|
|
|
|
A. Melnick, G. W. Carlile, M. J. McConnell, A. Polinger, S. W. Hiebert, and J. D. Licht
AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein
Blood,
December 1, 2000;
96(12):
3939 - 3947.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. de Winter, L. van der Weel, J. de Groot, S. Stone, Q. Waisfisz, F. Arwert, R. J. Scheper, F. A.E. Kruyt, M. E. Hoatlin, and H. Joenje
The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG
Hum. Mol. Genet.,
November 1, 2000;
9(18):
2665 - 2674.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Melnick, K. F. Ahmad, S. Arai, A. Polinger, H. Ball, K. L. Borden, G. W. Carlile, G. G. Prive, and J. D. Licht
In-Depth Mutational Analysis of the Promyelocytic Leukemia Zinc Finger BTB/POZ Domain Reveals Motifs and Residues Required for Biological and Transcriptional Functions
Mol. Cell. Biol.,
September 1, 2000;
20(17):
6550 - 6567.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Q. Pang, S. Fagerlie, T. A. Christianson, W. Keeble, G. Faulkner, J. Diaz, R. K. Rathbun, and G. C. Bagby
The Fanconi Anemia Protein FANCC Binds to and Facilitates the Activation of STAT1 by Gamma Interferon and Hematopoietic Growth Factors
Mol. Cell. Biol.,
July 1, 2000;
20(13):
4724 - 4735.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. C. Heinrich, K. V. Silvey, S. Stone, A. J. Zigler, D. J. Griffith, M. Montalto, L. Chai, Y. Zhi, and M. E. Hoatlin
Posttranscriptional cell cycle-dependent regulation of human FANCC expression
Blood,
June 15, 2000;
95(12):
3970 - 3977.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-J. C. Tang, C.-K. Chuang, H.-M. Hu, and T. K. Tang
The Zinc Finger Domain of Tzfp Binds to the tbs Motif Located at the Upstream Flanking Region of the Aie1 (aurora-C) Kinase Gene
J. Biol. Chem.,
May 25, 2001;
276(22):
19631 - 19639.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
