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Blood, Vol. 94 No. 11 (December 1), 1999:
pp. 3928-3940
Human Cord Blood Progenitors Sustain Thymic T-Cell Development and
a Novel Form of Angiogenesis
Laura Crisa,
Vincenzo Cirulli,
Kent A. Smith,
Mark H. Ellisman,
Bruce E. Torbett, and
Daniel R. Salomon
From the Departments of Molecular and Experimental Medicine and the
Department of Immunology, The Scripps Research Institute, La Jolla, CA;
and the Department of Pediatrics, The Whittier Institute and the
National Center for Microscopy and Imaging Research, University of
California San Diego, CA.
There is growing interest in using human umbilical cord blood (CB)
for allogeneic bone marrow transplantation (BMT), particularly in
children. Thus, CB has been identified as a rich source of hematopoietic progenitors of the erythroid, myeloid, and B-cell lineages. Whether CB blood cells engrafting in the BM space also comprise T-cell progenitors capable of trafficking to the thymus and
reconstituting a functional thymopoiesis in young recipients is
presently unknown. Here, we show that CB progenitors, engrafted in the
BM of immunodeficient mice, sustain human thymopoiesis by generating
circulating T-cell progenitors capable of homing to and developing
within a human thymic graft. Surprisingly, development of CB stem cells
in this in vivo model extended to elements of the endothelial cell
lineage, which contributed to the revascularization of transplants and
wound healing. These results demonstrate that human CB stem cell
transplantation can reconstitute thymic-dependent T-cell lymphopoiesis
and show a novel role of CB-derived hematopoietic stem cells in angiogenesis.
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