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Blood, Vol. 94 No. 8 (October 15), 1999:
pp. 2622-2636
Gene Duplication of Zebrafish JAK2 Homologs Is Accompanied by
Divergent Embryonic Expression Patterns: Only jak2a Is
Expressed During Erythropoiesis
Andrew C. Oates,
Alison Brownlie,
Stephen J. Pratt,
Danielle V. Irvine,
Eric C. Liao,
Barry H. Paw,
Kristen J. Dorian,
Stephen L. Johnson,
John H. Postlethwait,
Leonard I. Zon, and
Andrew F. Wilks
From the Ludwig Institute for Cancer Research, Melbourne Tumour
Biology Branch, Royal Melbourne Hospital, Victoria, Australia; the
Howard Hughes Medical Institute, Children's Hospital, Boston, MA; the
Department of Genetics, Washington University Medical School, St Louis,
MO; and the Institute of Neurosciences, University of Oregon, Eugene,
OR.
Members of the JAK family of protein tyrosine kinase (PTK) proteins
are required for the transmission of signals from a variety of cell
surface receptors, particularly those of the cytokine receptor family.
JAK function has been implicated in hematopoiesis and regulation of the
immune system, and recent data suggest that the vertebrate JAK2
gene may play a role in leukemia. We have isolated and characterized
jak cDNAs from the zebrafish Danio rerio. The
zebrafish genome possesses 2 jak2 genes that occupy paralogous
chromosome segments in the zebrafish genome, and these segments
conserve syntenic relationships with orthologous genes in mammalian
genomes, suggesting an ancient duplication in the zebrafish lineage.
The jak2a gene is expressed at high levels in erythroid
precursors of primitive and definitive waves and at a lower level in
early central nervous system and developing fin buds. jak2b is
expressed in the developing lens and nephritic ducts, but not in
hematopoietic tissue. The expression of jak2a was examined in
hematopoietic mutants and found to be disrupted in cloche
and spadetail, suggesting an early role in hematopoiesis. Taken together with recent gene knockout data in the mouse, we suggest
that jak2a may be functionally equivalent to mammalian Jak2, with a role in early erythropoiesis.
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